Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development
BioMed Research International, Volume 2019, 8 pages, https://doi.org/10.1155/2019/8326246
Maryam Mukhtar,1 Nadeem Sheikh,1 Saira Kainat Suqaina,1 Andleeb Batool,2 Naz Fatima,1 Rabia Mehmood,1 and Sabeen Nazir1 s_nadeem77 at yahoo.com
1 Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
2 Department of Zoology, Government College University, Lahore 54000, Pakistan
The Vitamin D receptor has been documented from restricting Vitamin D to many tissues
Sometimes the VDR being poor is the probable cause of the disease
Sometimes the disease, like breast cancer, is the cause of the VDR deactivation
This study cannot indicate if the poor VDR is the cause or the result of the arthritis
The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Vitamin D Receptor table shows what might increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Rheumatoid Arthritis
Items in both categories Rheumatoid Arthritis and Vitamin D Receptor
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D in rheumatoid arthritis-towards clinical application – April 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Rheumatoid arthritis, genes and vitamin D – May 2013
Overview Rheumatoid Arthritis and vitamin D
Meta-analysis of Rheumatoid Arthritis and Vitamin D in VitaminDWiki
- Rheumatoid Arthritis pain is reduced by Vitamin D, high doses also reduced inflammation (CRP) – Meta-analysis July 2023
- Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018
- Rheumatic diseases not helped by Vitamin D – if you ignore what and how much was given – meta-analysis June 2017
- Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
- Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Juvenile Rheumatoid Arthritis associated with low vitamin D, but how low – meta-analysis Jan 2013
- Rheumatoid arthritis 24 percent more likely if low vitamin D consumption– meta-analysis Sept 2012
Meta-analysis of Osteroarthritis and Vitamin D in VitaminDWiki
- Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023
- Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020
- Widespread pain, arthritis pain and muscle pain are associated with low vitamin D – meta-analysis March 2018
- Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015
Download the PDF from VitaminDWiki
Haplotype: rs10735810; rs7975232; rs1544410; rs731236
Notice the huge increase in poor versions of the VDR in those with arthritis vs the controls
It appears, for example, that 30% of those with RA had poor CGAT,
but 0% of the controls had poor CGAT
Rheumatoid Arthritis
Osteoarthritis
Both RA and OA
From PDF: "In Pakistan, 70% of marriages are cousin marriage"
This explains why Vitamin D Receptor problems are so strongly associated with arthritis in Pakistan
Vitamin D is an anti-inflammatory molecule and has a role in prevention of arthritis development. Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. VDR gene polymorphism leads to dysfunctioning of 1, 25(OH)2D3 ultimately disease onset. The purpose of current study was to evaluate the effect of vitamin D level and VDR gene polymorphism on rheumatoid arthritis and osteoarthritis. Blood samples were collected from case and control after taking written consent. Serum was separated and vitamin D level as determined from each sample by ELISA. DNA was extracted from each blood sample and amplified by using gene specific primers. Genotyping was performed by Sangers sequencing and PCR-RFLP technique. It was found that vitamin D level was not significantly different among patients and controls. The rs10735810, rs1544410, rs7975232, and rs731236 were associated with the onset of arthritis at both allelic and genotypic level (p < 0.01). Nucleotide change on rs10735810 site leads to change of tryptophan with arginine. The frequencies of haplotype CGAT, CGGA, CGGT, CTAA, CTAT, TGAA, TGAT, TGGA, and TTGA were higher in patients and act as risk factors of RA onset, whereas haplotypes CGAT, CGAT, CGGT, CTGA, TGAT, TGGA, TTAA, and TTGA were associated with OA onset. In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.