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Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019

Vitamin D Receptor Gene Polymorphism: An Important Predictor of Arthritis Development

BioMed Research International, Volume 2019, 8 pages, https://doi.org/10.1155/2019/8326246
Maryam Mukhtar,1 Nadeem Sheikh,1 Saira Kainat Suqaina,1 Andleeb Batool,2 Naz Fatima,1 Rabia Mehmood,1 and Sabeen Nazir1 s_nadeem77 at yahoo.com
1 Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-i-Azam Campus, Lahore 54590, Pakistan
2 Department of Zoology, Government College University, Lahore 54000, Pakistan


The Vitamin D receptor has been documented from restricting Vitamin D to many tissues
Sometimes the VDR being poor is the probable cause of the disease
Sometimes the disease, like breast cancer, is the cause of the VDR deactivation
This study cannot indicate if the poor VDR is the cause or the result of the arthritis

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Vitamin D Receptor table shows what might increase VDR activation
Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Rheumatoid Arthritis

Items in both categories Rheumatoid Arthritis and Vitamin D Receptor

Overview Rheumatoid Arthritis and vitamin D
Meta-analysis of Rheumatoid Arthritis and Vitamin D in VitaminDWiki

Meta-analysis of Osteroarthritis and Vitamin D in VitaminDWiki

 Download the PDF from VitaminDWiki

Haplotype: rs10735810; rs7975232; rs1544410; rs731236

Notice the huge increase in poor versions of the VDR in those with arthritis vs the controls
It appears, for example, that 30% of those with RA had poor CGAT,
   but 0% of the controls had poor CGAT

Rheumatoid Arthritis


Both RA and OA

From PDF: "In Pakistan, 70% of marriages are cousin marriage"
This explains why Vitamin D Receptor problems are so strongly associated with arthritis in Pakistan

Vitamin D is an anti-inflammatory molecule and has a role in prevention of arthritis development. Biologically active form 1, 25(OH)2D3 of vitamin D can only exert its action after binding its definite vitamin D receptor encoded by VDR gene. VDR gene polymorphism leads to dysfunctioning of 1, 25(OH)2D3 ultimately disease onset. The purpose of current study was to evaluate the effect of vitamin D level and VDR gene polymorphism on rheumatoid arthritis and osteoarthritis. Blood samples were collected from case and control after taking written consent. Serum was separated and vitamin D level as determined from each sample by ELISA. DNA was extracted from each blood sample and amplified by using gene specific primers. Genotyping was performed by Sangers sequencing and PCR-RFLP technique. It was found that vitamin D level was not significantly different among patients and controls. The rs10735810, rs1544410, rs7975232, and rs731236 were associated with the onset of arthritis at both allelic and genotypic level (p < 0.01). Nucleotide change on rs10735810 site leads to change of tryptophan with arginine. The frequencies of haplotype CGAT, CGGA, CGGT, CTAA, CTAT, TGAA, TGAT, TGGA, and TTGA were higher in patients and act as risk factors of RA onset, whereas haplotypes CGAT, CGAT, CGGT, CTGA, TGAT, TGGA, TTAA, and TTGA were associated with OA onset. In conclusion, serum vitamin D level may be normal among arthritis patients but polymorphism on VDR gene restricts vitamin D to perform its anti-inflammatory function by altering the 1, 25(OH)2 D3 binding sites.

Created by admin. Last Modification: Friday August 16, 2019 11:00:45 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
11803 VDR arthritis T4.jpg admin 24 Apr, 2019 11:13 103.72 Kb 457
11599 RA VDR.jpg admin 18 Mar, 2019 12:31 45.22 Kb 550
11598 RA VDR.jpg admin 18 Mar, 2019 12:31 45.22 Kb 247
11597 OA VDR.jpg admin 18 Mar, 2019 12:05 33.69 Kb 434
11595 Arthritis VDR.pdf PDF 2019 admin 18 Mar, 2019 11:59 1.73 Mb 567
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