Genetics of Obstructive Sleep Apnea: Vitamin D Receptor Gene Variation Affects Both Vitamin D Serum Concentration and Disease Susceptibility.
OMICS. 2018 Dec 18. doi: 10.1089/omi.2018.0184. [Epub ahead of print]
Ragia G1, Archontogeorgis K2, Simmaco M3, Gentile G3, Borro M3, Zissimopoulos A4, Froudarakis M5, Manolopoulos VG1, Steiropoulos P2,5.
- 49 diseases were strongly associated with Vitamin D Receptor as of Dec 2018
Sleep category starts with
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleep problems cured by vitamin D, etc. – workshops and patient workbooks – Gominak 2018
- Sleeps disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Iron deficiency is a cause of Vitamin D deficiency Depression
- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- Vitamin D for better sleep video - Dec 2021
- 5X increase in sleep problems in a decade in US Veterans
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Obstructive sleep apnea syndrome (OSAS) is a multifactorial and common disorder affecting 10-17% of men and 3-9% of women. A low vitamin D serum concentration has been reportedly linked to OSAS susceptibility, but the underlying molecular genetic mechanisms are poorly understood thus far. We report here original findings on the ways in which vitamin D receptor (VDR) gene polymorphic variation (FokI, BsmI, ApaI, and TaqI polymorphisms) impacts serum vitamin D concentration and, additionally, susceptibility to OSAS. In a sample of 176 consecutive subjects (144 patients with OSAS and 32 healthy controls) phenotyped by full polysomnography (PSG), we characterized human genetic variation in VDR using the Sequenom MassARRAY iPLEX platform. A logistic regression analysis was employed to account and correct for covariates such as sex, age, body mass index, and comorbidities. Importantly, we observed that the FokI CC genotype frequency was markedly higher in patients with OSAS compared with controls (50.7% vs. 28.1%; p = 0.027). VDR FokI polymorphism explained 14.5% of vitamin D serum concentration variability. Moreover, the VDR FokI polymorphism was also associated with excessive daytime sleepiness (p = 0.016). To the best of our knowledge, this is the first clinical genetics study examining the role of VDR polymorphic variation on OSAS as phenotyped using full PSG. We call for further studies of vitamin D-related mechanisms that might contribute to OSAS risk in independent populations.
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