Novel biomarker for predicting sepsis mortality: vitamin D receptor
Journal of International Medical Research https://doi.org/10.1177/03000605211034733
Murat Erdoğan, Hüseyin Avni FındıklıFirst
There are 2 easy ways to get past a VDR restriction
1) Take Vitamin D in high, infrequent doses
2) Take one of more supplements that have been proven to activate the receptor
Items in both categories VDR and Mortality:
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
Note: My father-in-law got sepsis in the hospital. I immediately gave him 200,000 IU of Vitamin D.
He left hospital 3 days later
I had not heard of an ELISA test kit for the VDR. This study got their $400 oil - (research purposes only) from https://www.mybiosource.com/
VitaminDWiki pages containing SEPSIS in title
Items found: 40
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Sepsis (with mechanical ventilation) treated by 5days of 50,000 IU of Vitamin D – RCT May 2024 |
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06 May, 2024 |
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Sepsis mortality greater in Black than White children (low vitamin D) - Dec 2023 |
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03 Dec, 2023 |
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Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis Sept 2023 |
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27 Sep, 2023 |
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Sepsis is both prevented and treated by Vitamin D - many studies |
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25 Sep, 2023 |
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Sepsis is fought by Vitamin D in 9 ways – Feb 2023 |
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13 Feb, 2023 |
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Doctors Still Struggle to Diagnose a Condition That Kills More Than Stroke (Sepsis, Vitamin D helps) Oct 2022 |
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16 Oct, 2022 |
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Sepsis patients 2.7 X more likely to die if low Vitamin D – Aug 2022 |
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11 Aug, 2022 |
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Vitamin D and infectious diseases like RTI, TB and Sepsis – Nov 2014 |
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16 Jan, 2022 |
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Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021 |
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16 Aug, 2021 |
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Vitamin C IV, which treats Sepsis, also treats COVID-19 - May 2020 |
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01 Aug, 2020 |
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3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020 |
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03 Jun, 2020 |
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Role and Mechanism of Vitamin D in Sepsis (Chinese) – Feb 2020 |
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27 Feb, 2020 |
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Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 |
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18 Dec, 2019 |
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Fewer Burn problems if adequate Vitamin D – Less ICU, Hospital, Sepsis (10X) – Dec 2019 |
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17 Dec, 2019 |
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Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019 |
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27 Jun, 2019 |
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Sepsis mortality cut in half with Omega-3 – RCT Sept 2017 |
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14 Apr, 2019 |
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Sepsis reduced the Omega-3 response and half life – April 2019 |
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14 Apr, 2019 |
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Vitamin D for Sepsis prevention – June 2018 |
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24 Jul, 2018 |
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Omega-3 reduced cost of Sepsis by 2900 dollars per patient (12 RCT) – April 2018 |
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24 Apr, 2018 |
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Neonatal Sepsis 4.8 X more likely if poor Vitamin D receptor – June 2018 |
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22 Apr, 2018 |
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Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018 |
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06 Apr, 2018 |
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Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018 |
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14 Mar, 2018 |
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Vitamin D deficiency with severe sepsis increased risk of dying by 7.7 X – Nov 2017 |
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20 Nov, 2017 |
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Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023 |
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23 Oct, 2017 |
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Sepsis was present in 6 percent of US adult hospitalizations – JAMA Oct 2017 |
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04 Oct, 2017 |
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Infant sepsis strongly associated with low vitamin D – Aug 2014 |
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16 Aug, 2017 |
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Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017 |
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24 Jul, 2017 |
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Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017 |
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13 Jun, 2017 |
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Severe Sepsis associated with very low vitamin D – Sept 2016 |
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26 May, 2017 |
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Increased Hospital, Sepsis deaths if low vitamin D – March 2014 |
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21 May, 2017 |
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Sepsis in first year of life is much more likely if preterm (low Vitamin D) – May 2017 |
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10 May, 2017 |
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Vitamin D might reduce sepsis |
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04 May, 2017 |
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More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013 |
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21 Sep, 2016 |
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Neonates with sepsis had half the levels of vitamin D - 2015 |
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30 Aug, 2016 |
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Newborns with sepsis – 9 ng of vitamin D, without sepsis 19 ng – Aug 2015 |
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30 Aug, 2016 |
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Sepsis associated with low vitamin D - April 2012 |
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22 Mar, 2016 |
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1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis Dec 2014 |
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20 Oct, 2015 |
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More sepsis deaths in those entering hospital with low vitamin D – Jan 2014 |
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07 Jun, 2014 |
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ICU surgical patients with low vitamin D stayed longer and had more sepsis – Dec 2011 |
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22 Jul, 2013 |
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Sepsis bacteria can be killed by blue as well as UV light – Jan 2013 |
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29 Jan, 2013 |
Download the PDF from VitaminDWiki
Objective
There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis.
Methods
This prospective cross-sectional observational study included 148 patients diagnosed with sepsis who were treated in the intensive care unit. We measured VDR levels, laboratory characteristics, and health scores and related them to survival.
Results
The 148 patients included 96 survivors and 52 non-survivors, with VDR levels of 1.92 and 1.36 ng/mL, respectively. Baseline VDR was a significant predictor of 28-day mortality, with an area under the curve of 0.778. A low VDR level was significantly associated with lower overall survival in patients with sepsis according to Kaplan–Meier curve analysis. VDR levels were also negatively correlated with lactate, C-reactive protein, acute physiological and clinical health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, and disease severity.
Conclusions
VDR levels were associated with high 28-day mortality and negatively correlated with lactate, C-reactive protein, APACHE II and SOFA scores, and disease severity in patients with sepsis. VDR levels can predict poor outcomes in patients with sepsis.