Summary of many studies of Vitamin D and organ transplantation
More vitamin D needed especially needed if organ = liver or kidney (low vitamin d ==> poor bones)
Both regular and active vitamin D have been used
Supplementation can be oral, injection, etc
Extra Vitamin D can be before or after the surgery
Problems avoided include: infection, rejection, death
Vitamin D in organ transplantation - 2011
Osteoporos Int. 2011 Jan 5.
Stein EM, Shane E.
Department of Medicine, Columbia University Medical Center, 630 West 168th Street, PH8-864, New York, NY, 10032, USA, es2029 at columbia.edu.
Vitamin D deficiency is prevalent among patients with end-stage organ failure awaiting transplant. Low serum 25-hydroxyvitamin D (25-OHD) levels in these patients may be related to many disease-specific factors, as well as decreased sunlight exposure and limited intake of foods containing vitamin D.
Low serum 25-OHD levels are also extremely common following solid organ transplantation, both during the immediate postoperative period and in long-term graft recipients.
Demographic and lifestyle factors are important in determining D status in transplant recipients.
Worse vitamin D status is associated with poorer general health, lower albumin, and even decreased survival among these patients.
Although several studies have demonstrated that active forms of vitamin D and its analogues prevent bone loss following transplantation, the data do not show consistent benefit.
These therapies may have particular utility after renal transplantation. However, given the narrow therapeutic window with respect to hypercalcemia and hypercalciuria, and the demonstrated efficacy of bisphosphonates to prevent post-transplantation bone loss, we regard these agents as adjunctive rather than primary therapy for transplantation osteoporosis.
The effects of 1,25(OH)(2)D on the immune system, which are still being elucidated, may have potential for reducing infections and preventing allograft rejection after transplantation. PMID: 21207011
Cited by 70 later studes as of March 2021
- Vitamin D Receptor Activity, Vitamin D Status, and Development of De-novo Donor-specific Antibody after Renal Transplantation - March 2020
Survive heart transplant better if have more vitamin D
PDF is attached at the bottom of this page
32+ VitaminDWiki pages have TRANSPLANT in title
Immune system is often supressed so that a new organ can be accepted by the body
But, the immune syetem is needed to avoid COVID-19
- immunosuppressants National Kidney Foundation
- COVID-19: Issues related to solid organ transplantation Feb 2021
- 'It's Kind of a Catch-22': Immunosuppression and COVID-19 Vaccines MedPageToday, March 23, 2021
- "A recent study found fewer than 20% of solid organ transplant patients mounted detectable antibodies to SARS-CoV-2 following a first dose of COVID-19 vaccine, raising questions about vaccine protection in this population compared to immunocompetent people."
- "Now in transplant patients, what we found is that only 17% have detectable antibody after dose one. "
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Includes immunosuppression as a risk factor
- General Approach to the Clinical Care of Solid Organ Transplant Recipients with COVID-19 Infection: Management for Transplant Recipients - Oct 2020  PDF
See also web
- Clinical Trials: Transplant and Vitamin D 101 listed as of Jan 2023
- Low Vitamin D Exposure is Associated with Higher Risk of Infection in Renal Transplant Recipients March 2017
-  Download the PDF from Sci-hub via VitaminDWiki
43% fewer infections within 90 days if Vitamin D > 30 ng
"Transplant patients with low calcidiol levels have an increased risk of
metabolic and endocrine problems,
type 2 diabetes mellitus,
poor graft survival,