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Vitamin D helps organ transplant

Summary of many studies of Vitamin D and organ transplantation

More vitamin D needed especially needed if organ = liver or kidney (low vitamin d ==> poor bones)
Both regular and active vitamin D have been used
Supplementation can be oral, injection, etc
Extra Vitamin D can be before or after the surgery
Problems avoided include: infection, rejection, death


Vitamin D in organ transplantation - 2011

Osteoporos Int. 2011 Jan 5.
Stein EM, Shane E.
Department of Medicine, Columbia University Medical Center, 630 West 168th Street, PH8-864, New York, NY, 10032, USA, es2029 at columbia.edu.

Vitamin D deficiency is prevalent among patients with end-stage organ failure awaiting transplant. Low serum 25-hydroxyvitamin D (25-OHD) levels in these patients may be related to many disease-specific factors, as well as decreased sunlight exposure and limited intake of foods containing vitamin D.

Low serum 25-OHD levels are also extremely common following solid organ transplantation, both during the immediate postoperative period and in long-term graft recipients.

Demographic and lifestyle factors are important in determining D status in transplant recipients.

Worse vitamin D status is associated with poorer general health, lower albumin, and even decreased survival among these patients.

Although several studies have demonstrated that active forms of vitamin D and its analogues prevent bone loss following transplantation, the data do not show consistent benefit.

These therapies may have particular utility after renal transplantation. However, given the narrow therapeutic window with respect to hypercalcemia and hypercalciuria, and the demonstrated efficacy of bisphosphonates to prevent post-transplantation bone loss, we regard these agents as adjunctive rather than primary therapy for transplantation osteoporosis.

The effects of 1,25(OH)(2)D on the immune system, which are still being elucidated, may have potential for reducing infections and preventing allograft rejection after transplantation. PMID: 21207011

Cited by 70 later studes as of March 2021


Survive heart transplant better if have more vitamin D

Image

PDF is attached at the bottom of this page


VitaminDWiki pages containing TRANSPLANT in content

Items found: 31
Title Modified
Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021 27 Aug, 2021
Liver transplants in children more likely to be rejected if insufficient vitamin D – Aug 2021 07 Aug, 2021
Very low Vitamin D levels after Liver transplant in children (need Calcitriol or topical) – May 2021 03 Jun, 2021
Kidney transplant rejection 1.8X more likely if low vitamin D – May 2021 22 May, 2021
1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021 22 Apr, 2021
Vitamin D helps organ transplant 24 Mar, 2021
Organ Transplant patients probably need more UV and or vitamin D April 2010 24 Mar, 2021
If you are getting a lung transplant you must have vitamin D - April 2012 24 Mar, 2021
Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 18 Dec, 2019
Stem cell transplant (HSCT) patients are dying due to lack of vitamin D – Oct 2019 28 Oct, 2019
Stem Cell Transplants consume vitamin D – July 2011 23 Oct, 2019
Stem cell transplant (HSCT). death 28 percent less likely for each 10ng higher vitamin D level – Oct 2019 23 Oct, 2019
Fecal transplants could prevent 12,000 C.difficile deaths a year, but one person died, so lets wait – July 2019 01 Aug, 2019
4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019 17 Jun, 2019
Fecal transplants increased Vitamin D levels (germ-free mice) – March 2018 29 Jun, 2018
Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 27 May, 2017
Bone marrow transplant – like other traumas – lowers vitamin D levels – July 2011 17 Apr, 2017
Vitamin D may help after organ transplant – if can give enough – Jan 2011 25 Mar, 2017
4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012 25 Mar, 2017
Kidney transplant patients advised to avoid the sun, then 90% have very low vitamin D levels – Sept 2012 25 Mar, 2017
Vitamin D and biophospates are needed after organ transplant – Aug 2011 25 Mar, 2017
Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014 28 Apr, 2016
Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011 26 Jul, 2015
Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 18 May, 2015
400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015 26 Mar, 2015
Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011 28 Aug, 2012
Babies Receive Heart Transplants Instead of Vitamin D Treatment 25 Jun, 2012
Kidney transplant worked better if initially have high level of vitamin D – April 2012 28 Apr, 2012
Vitamin D levels low both before and after organ transplant July 2011 27 Apr, 2012
Heart transplant 19 ng vitamin D vs liver transplant 13 ng – April 2009 12 Nov, 2011
Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012 No value for 'modification_date_major'

Immune system is often supressed so that a new organ can be accepted by the body
But, the immune syetem is needed to avoid COVID-19


See also web

Attached files

ID Name Comment Uploaded Size Downloads
15309 Transplant Oct 2020.pdf admin 24 Mar, 2021 11:10 514.38 Kb 53
15308 Renal Transplantation March 2020.pdf PDF 2020 admin 24 Mar, 2021 11:05 293.80 Kb 61
15307 Kidney transplant 2017.pdf admin 24 Mar, 2021 10:46 524.95 Kb 54
1887 Heart Transplant survival vs calcitriol.jpg admin 28 Dec, 2012 16:08 24.26 Kb 1366
1886 Vitamin D in organ transplantation.pdf PDF admin 28 Dec, 2012 16:03 326.33 Kb 721
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