Overview Metabolic Syndrome and vitamin D

Metabolic Syndrome category has the following

105 items

See also

• Overview Metabolic Syndrome and vitamin D
• Overview Diabetes and vitamin D
• Overview Obesity and Vitamin D
• Diabetes, Metabolic Syndrome and Magnesium - many studies
• Arteries and Atherosclerosis and Vitamin D - many studies
• Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
• Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
• Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
• Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
• Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
• Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
• Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
• Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
• Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
• Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
  

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WikiPedia Metabolic Syndrome

Metabolic syndrome is a combination of medical disorders that, when occurring together, increase the risk of developing cardiovascular disease and diabetes
It affects one in five people in the United States and prevalence increases with age.
Some studies have shown the prevalence in the USA to be an estimated 25% of the population
Many different definitions of Metabolic Syndrome
{which include some combination of Diabetes, obesity, hypertension, Elevated triglycerides, High-sensitivity, C-reactive protein, Reduced HDL cholesterol}

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See also VitaminDWiki

• Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
• Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
• Metabolic Syndrome among obese 4X more likely if low vitamin D – July 2013
• Metabolic Syndrome 70 percent more likely if vitamin D insufficient - March 2012
• Metabolic Syndrome reduced 2X after one year of more sunlight - Nov 2011
• Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
• Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
• Sudden death 6X more likely with Metabolic Syndrome and low vitamin D - March 2012
• Vitamin D and metabolic syndrome - April 2012 need more vitamin D
• Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
• Fatty liver disease (NAFLD), metabolic syndrome, and perhaps vitamin D – June 2013
• Metabolic Syndrome 3X less likely in college students with enough vitamin D – June 2014
• Metabolism and Inflammation are also regulated by Vitamin D – 2014
• Metabolic Syndrome risk decreases 12 percent with 150 mg of Magnesium – meta-analysis Dec 2014

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Vitamin D measurements, Vit D Binding Protein, and Metabolic Syndrome - June 2017

Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components.
Arch Med Sci. 2017 Jun;13(4):745-752. doi: 10.5114/aoms.2016.58594. Epub 2016 Mar 16.
Pelczyńska M1, Grzelak T1, Sperling M1, Bogdański P2, Pupek-Musialik D3, Czyżewska K1.

INTRODUCTION:
Various forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other.

MATERIAL AND METHODS:
The studies were conducted on 79 people, including 52 with metabolic syndrome (MetS+) and 27 without it (MetS-). Biochemical measurements (lipid profile, glycemia, 25(OH)D, VDBP, albumin, calcium, parathyroid hormone) were performed, concentration of free and bioavailable vitamin D was mathematically calculated, and anthropometric and blood pressure measurements were taken.

RESULTS:
The mean ± SD concentration of 25(OH)D among MetS+ individuals (41.90 ±13.12 nmol/l) was lower (p < 0.0001) than among the MetS- group (66.09 ±18.02 nmol/l). Differences between groups were observed in relation to medians/means of concentrations of free and bioavailable vitamin D (p < 0.0001) but not in the case of VDBP. In the entire study population, 25(OH)D correlated with all metabolic syndrome components, whereas its free and bioavailable fraction correlated with particular components of the syndrome. In the MetS+ group, VDBP concentration negatively correlated with body mass index (p = 0.037) and levels of diastolic pressure (p = 0.022). In the case of the MetS- group, the free fraction of vitamin D negatively correlated with triglyceridemia (p = 0.049).

CONCLUSIONS:
The evaluation of various forms of vitamin D and VDBP in different population groups seems to have significant clinical value in evaluating the prevalence of metabolic disorders.
 Download the PDF from VitaminDWiki

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See also Clinical Trials for Metabolic Syndrome

• Metabolic Syndrome and Vitamin D Intervention 35 as of Aug 2021
• Vitamin D and Glucose Metabolism in Pediatrics 3,000 IU vitamin D

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Metabolic Syndrome 13% more likely for each 10 ng decrease in vitamin D - meta-analysis - March 2014

Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis.
J Clin Endocrinol Metab. 2014 Mar;99(3):1053-63. doi: 10.1210/jc.2013-3577. Epub 2013 Jan 1.
Ju SY1, Jeong HS, Kim do H.
1Department of Family Medicine (S.Y.J.), Yeouido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea; Department of Preventive Medicine (H.S.J.), Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea; and Department of Family Medicine (D.H.K.), Korea University Ansan Hospital, Korea University College of Medicine, Seoul 136-705, Korea.

• CONTEXT: Increasing evidence has suggested an association between blood vitamin D levels and metabolic syndrome.
• OBJECTIVE: Our objective was to determine the relationship between blood vitamin D status and metabolic syndrome in the general adult population, using a dose-response meta-analysis.
• DATA SOURCE: We searched the PubMed, EMBASE, Web of Science, and Cochrane Library databases through July 2013 to identify relevant studies.
• STUDY SELECTION: Observational studies, reporting risk ratios with a 95% confidence interval (CI) for metabolic syndrome in ≥3 categories of blood 25-hydroxyvitamin D [25(OH)D] levels, were selected.
• DATA EXTRACTION: Data extraction was performed independently by 2 authors, and the quality of the studies was evaluated using the risk of bias assessment tool for nonrandomized studies.
• DATA SYNTHESIS: The pooled odds ratio of metabolic syndrome per 25 nmol/L increment in the serum/plasma 25(OH)D concentration was 0.87 (95% CI = 0.83-0.92, I(2) = 85%), based on 16 "cross-sectional studies" and 1.00 (95% CI = 0.98-1.02, I(2) = 0%) for 2 "cohort and nested case-control studies." The dose-response meta-analysis showed a generally linear, inverse relationship between 25(OH)D levels and metabolic syndrome in the cross-sectional studies (P for linear trend < .001).
• CONCLUSIONS: Blood vitamin D levels were associated with a risk of metabolic syndrome in cross-sectional studies but not in longitudinal studies. Randomized, clinical trials will be necessary to address the issue of causality and to determine whether vitamin D supplementation is effective for the prevention of metabolic syndrome.

PMID: 24423309

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Some PubMed items

• Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome: a randomized controlled double-blind clinical trial Nov 2016
  50,000 IU weekly for 16 weeks was not enough - everyone, even in control group, started Vitamin D deficient PDF $40
• Vitamin D Deficiency in Relation to the Risk of Metabolic Syndrome in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus 2016
  3.3 X more likely, free PDF online
• Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans July 2016
  metabolic syndrome and low Vitamin D ==> cognitive impairment 3.1 X more likely; Rent PDF from publisher for $6
• Is the Association between Vitamin D and Metabolic Syndrome Independent of Other Micronutrients July 2016
  vitamin A, zinc , and magnesium Publisher wants $28 for the PDF
• White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging Jan 2018
   Download the PDF from SciHub via VitaminDWiki
• Dietary Fiber and Metabolic Syndrome: A Meta-Analysis and Review of Related Mechanisms. Dec 2017
  33% reduction - same as a 25 ng increase in Vitamin D (see 2014 meta-analysis above) Free PDF online

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Metabolic Syndrome and Fructose - Mercola Jan 2015

Health Tips from a Grizzly

• I highly recommend reading Dr. Richard Johnson's book The Fat Switch (2012)
• Johnson: metabolic syndrome really should be called the fat-storage condition, because it’s just fat storage.
• Johnson video March 2014
• Humans share the genes with other animals which use fructose to store fat
• However, humans lack the ability to turn off the "fat switch" (most hypernating animals)
• Recommends < 25 grams of frutose, and for some people < 15 grams

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Vitamin D and Metabolic Diseases: Growing Roles of Vitamin D (VDR & RXR) - Dec 2018

 Download the PDF from VitaminDWiki

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Metabolic Syndrome images from web (nothing about vitamin D)

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Standard weight - 3X more likely to die if also have MetS (CDC 2020)

The Influence of Metabolic Syndrome in Predicting Mortality Risk Among US Adults: Importance of Metabolic Syndrome Even in Adults With Normal Weight PDF