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Certain types of Tuberculosis are 2X more likely with a poor Vitamin D Receptor – April 2019

Associations between vitamin D receptor genetic variants and tuberculosis: a meta-analysis

Innate Immunity 0(0) 1-9, DOI: 10.1177/1753425919842643
Xun Xu and Minghao Shen

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We performed a meta-analysis to evaluate potential associations between vitamin D receptor (VDR) genetic variants and tuberculosis (TB). Systematic literature research was conducted in PubMed, Web of Science, and Embase. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations in all possible genetic models, and P values < 0.05 were considered to be statistically significant. In total, 42 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rsl5444I0 (dominant model: P = 0.02; allele model: P = 0.03) and rs73l236 (dominant model: P = 0.04; recessive model: P = 0.02; allele model: P = 0.01) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rsI5444I0 (dominant and allele models) and rs73I236 (dominant, recessive, and allele models) variants were both significantly associated with TB in South Asians. When we stratified data by type of disease, positive results were detected for rs7975232 variant in EPTB (dominant, recessive, over-dominant, and allele models) subgroup, and for rs2228570 variant in PTB (dominant, recessive, and allele models) and EPTB (dominant, recessive, over-dominant, and allele models) subgroups. Our meta-analysis supported that rs7975232, rsI5444I0, rs2228570, and rs73I236 variants might serve as genetic biomarkers of certain types of TB.

Created by admin. Last Modification: Saturday April 20, 2019 15:05:12 GMT-0000 by admin. (Version 4)

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