Toggle Health Problems and D

Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016

Meta-analysis on vitamin D receptor and cancer risk: focus on the role of TaqI, ApaI, and Cdx2 polymorphisms.

Eur J Cancer Prev. 2016 Jan;25(1):85-96. doi: 10.1097/CEJ.0000000000000132.
Serrano D1, Gnagnarella P, Raimondi S, Gandini S.
1Divisions of aCancer Prevention and Genetics bEpidemiology and Biostatistics; European Institute of Oncology, Milan Italy.

See also VitaminDWiki

The items in both Colon Cancer and Vitamin D Receptor categories are listed here:

Pages listed in BOTH the categories Colon Cancer and Genetics

55 studies had referenced this study as of July 2022

  • Vitamin D Receptor Polymorphisms and Cancer - Sept 2020 https://doi.org/10.1007/978-3-030-46227-7_4
  • The Role of Vitamin D Receptor Gene Polymorphisms in Colorectal Cancer Risk - May 2020 https://doi.org/10.3390/cancers12061379 FREE PDF
  • The impact of vitamin D pathway genetic variation and circulating 25-hydroxyvitamin D on cancer outcome: systematic review and meta-analysis March 2017 doi:10.1038/bjc.2017.44 Free PDF
  • Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence May 2016 Free PDF
  • Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges Jan 2017 https://doi.org/10.1093/epirev/mxx005 Free PDF
  • Vitamin D Receptor Polymorphism and Cancer: An Update Aug 2017 Free PDF
  • Vitamin D receptor polymorphisms or serum levels as key drivers of breast cancer development? The question of the vitamin D pathway| Feb 2017 10.18632/oncotarget.14482 Free PDF
  • Association of select vitamin D receptor gene polymorphisms with the risk of tobacco-related cancers – a meta-analysis Nov 2019 [https://www.nature.com/articles/s41598-019-52519-5| Free PDF
  • The Significance of Vitamin D Status in Breast Cancer: A State of the Science Review April 2019 https://doi.org/10.1111/jmwh.12968

 Download the PDF from VitaminDWiki

Vitamin D plays a significant role in our health, including cancer incidence and mortality. Vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) may affect its activity, influencing the risk of cancer. Several studies have investigated VDR SNPs, but the association with the risk of cancer is controversial. Here, we present a meta-analysis to assess the association of TaqI, ApaI, and Cdx2 SNPs with the risk of cancer. A systematic literature search was performed following a predefined protocol and using validated search strategies. This meta-analysis shows the summary odd ratio (SOR) overall, by cancer sites and by ethnicity.

Up to January 2014, we identified 73 independent studies with 35,525 cases and 38,675 controls.
The meta-analysis of Cdx2 gg versus GG showed a significant 12% increased risk for all cancers [SOR=1.12; 95% confidence interval (CI): 1.00-1.25].
The other SNPs analyzed did not show an overall significant association with the risk of cancer: SOR=0.98 (95% CI: 0.90-1.07) and 1.06 (95% CI: 0.95-1.19) for TaqI tt versus TT and ApaI aa versus AA, respectively.
TaqI shows a significant 43% increased risk for colorectal cancer (SOR=1.43; 95% CI: 1.30-1.58 for tt vs. TT). Strong frequency variations are present among different ethnic groups. This meta-analysis showed an overall increased risk of cancer associated with Cdx2 SNP and a specific higher risk of colorectal cancer associated with the TaqI polymorphism. The VDR genotype might become more relevant when clustered in a specific haplotype, associated with other SNPs of genes involved in vitamin D metabolism, or for specific tumors and/or patient characteristics.

PMID: 25738688 PMCID: PMC4885539

Title was revised Nov 2019 which caused the visitor count to reset.
There have actually been 5893 visitors to this page since it was originally made

Created by admin. Last Modification: Wednesday July 27, 2022 17:05:48 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
7098 VDR Cancer Meta.jpg admin 23 Sep, 2016 182.80 Kb 1064
7097 VDR Cancer Meta-analysis.pdf admin 23 Sep, 2016 333.96 Kb 780