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Overview Gut and vitamin D

Did you know?
  • High level of vitamin D/UV reduces the risk of many gut problems
  • Many gut problems result in less absorption of Vitamin D & Magnesium . . .
    Not restoring Vitamin D levels increases the risk of many other diseases
  • Increasing Vitamin D reduces many inflammations - incude those of the gut
  • Several companies make gut-friendly forms of vitamin D
  • There are 204 items in the Gut category in VitaminDWiki
          (more GUT information below)

Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column or here
  see also Supplementing and More in the menu at the top of every page
If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Proof that Vitamin D Works   Getting Vitamin D into your body

Is 50ng enough?   How to restore levels quickly  VitaminDWiki interview and transcript - Jan 2022
Books and Videos 263   Diseases that may be related via low vitamin D
Reasons for low response to vitamin D   Why are doctors reluctant
Cancer studies include:   Breast 252   Colon 141   Lung 54   Prostate 101   Pancreatic 55   Skin 121
Colds and flu   Dark Skin 464   Diabetes 541   Obesity 432   Pregnancy 896   Seniors 431
COVID-19 treated by Vitamin D - studies, reports, videos

Gut Summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 204 items

See VitaminDWiki (other than Crohn's)

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9 gut problems - in order of prevelance - Perplexity AI June 2024

  1. Irritable Bowel Syndrome (IBS) - Affects 12% of the US population, making it the most common digestive disorder.
  2. Gastroesophageal Reflux Disease (GERD) - Along with IBS, GERD is noted as one of the digestive disorders seeing a noticeable rise in incidence.
  3. Constipation - Chronic constipation affects 15-30% of Canadians and is especially common in young children and the elderly.

Inflammatory Bowel Disease (IBD) - IBD, which includes Crohn's disease and ulcerative colitis, had an estimated 4.9 million prevalent cases globally in 2019.

  1. Gastritis - Inflammation of the stomach lining, commonly caused by H. pylori infection, NSAIDs, or alcohol.
  2. Peptic Ulcers - Often associated with gastritis and caused by H. pylori infection or NSAID use.
  3. Pancreatitis - Had an estimated 2.41 million prevalent cases globally in 2019.
  4. Appendicitis - Had an estimated 0.67 million prevalent cases globally in 2019.
  5. Paralytic Ileus and Intestinal Obstruction - Had an estimated 0.55 million prevalent cases globally in 2019.

4 gut problems are associated with low vitamin D levels - Perplexity AI June 2024

  • Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis:
    Vitamin D deficiency is more common among those with IBD.
    Lower vitamin D levels are associated with higher disease activity and severity in Crohn's disease.
    Vitamin D deficiency may be implicated in the etiology and severity of IBD.
    Individuals with higher serum vitamin D have a lower incidence of IBD, particularly Crohn's disease.
  • Constipation:
    A study found that patients with chronic functional constipation and intestinal motility disorders had lower vitamin D levels compared to healthy controls.
    Low vitamin D levels were significantly correlated with constipation symptoms and impaired quality of life in these patients.
  • Diarrhea:
    Low vitamin D levels are associated with an increased risk of rotaviral diarrhea in children under 5 years old.
    A study found lower vitamin D levels in children with acute bacterial diarrhea compared to healthy children.
  • General Gastrointestinal Inflammation:

Vitamin D plays a role in maintaining gastrointestinal barrier integrity, regulating gut microbiota, and modulating inflammatory immune responses, which are important in preventing and ameliorating gut inflammation.
References


87% of eating disorders got worse with COVID-19 - Aug 2020

Exploring the impact of the COVID-19 pandemic and UK lockdown on individuals with experience of eating disorders
UK study, FREE PDF


Many gut diseases will do better with gut-friendly forms of Vitamin D

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be usefulit is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

See also web

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Review of IBD and Vitamin D (generally < 1,000 IU) - Feb 2014

Review of observational and intervention studies
 Download the PDF from VitaminDWiki


SBI can help Colitis - Aug 2022

SBI = Serum-Derived Bovine Immunoglobulin/Protein Isolate,
by Eugene Heyden


IBS vs IBD

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Colon Diseases

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Celiac


Celiac assocated with both low vitamin D and poor Vitamin D Receptor - meta-analsys - Feb 2023

A meta-analysis suggests the association of reduced serum level of vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin D receptor gene with celiac disease
Front Nutr . 2023 Jan 19;9:996450. doi: 10.3389/fnut.2022.996450
Tanya Shree 1, Pratibha Banerjee 1, Sabyasachi Senapati 1

Purpose: As an immune-modulator, vitamin D is known to regulate immune response and is implicated in disease pathogenesis. Celiac disease (CD) is a systemic autoimmune disease and susceptibility conferred by vitamin D metabolism is under investigation. Studies on the association of vitamin D metabolism and genetic polymorphisms are expected to explain CD pathogenesis. We performed a systematic review-based meta-analysis to investigate the 25(OH)D serum levels and susceptibility conferred by the genetic variants of VDR in CD.

Methods: Systematic review was conducted through a web-based literature search following stringent study inclusion-exclusion criteria. The Newcastle-Ottawa Scale and GRADE tools were used to assess the quality of evidence in studies and the study outcome. Cohen's κ value was estimated to access the reviewer's agreement. RevMan 5.4.1 was used to perform the meta-analyses. Weighted mean difference and Meta p-value was assessed for 25(OH)D serum levels. Meta-odds ratio and Z-test p-value were evaluated to estimate the allelic susceptibility of VDR variants.

Results: A total of 8 out of 12 studies were evaluated for "25(OH)D" serum level, while four studies were found eligible for SNPs (Bsm1, Apa1, Fok1, and Taq1) of VDR. Significantly higher levels [WMD = 5.49, p < 0.00001] of 25(OH)D were observed in healthy controls than in patients with CD. rs2228570-T (Fok1) [Meta-OR = 1.52, p = 0.02] was confirmed to be predisposing allele for CD.

Conclusion: Reduced serum level of 25(OH)D and association of Fok1 T-allele of VDR confirmed in this study plays a critical role in immunomodulation and maintaining barrier integrity, which is majorly implicated in CD.
 Download the PDF from VitaminDWiki


Celiac disease is the most common genetic disease in Europe.

In Italy about 1 in 250 people and in Ireland about 1 in 300 people have celiac disease.
from http://www.wrongdiagnosis.com/c/celiac_disease/prevalence.htm


Celiac Disease is similar to Crohn's Disease in that both decrease vitamin D which can be absorbed in the gut

Celiac Disease may be similar to Crohn's Disease on the following chart

Possible Vitamin D Interactions


Does Gluten-Free Diet Protect Children with Celiac Disease from Low Bone Density? - Aug 2014

 Download the PDF from VitaminDWiki.
They believe: CD ==> poor absorption ==> low vitamin D ==> low Bone Mineral Density
They conclude that if teen with CD has bone pain should have DXA test of BMD, then might consider giving vitamin D.


8+ VitaminDWiki pages with CELIAC in title

This list is automatically updated

Items found: 11

Crohn's


Crohn's reduced by plant-based diet - Dr. Greger

Crohn's reactions to yeast, milk, eggs - good video review of many studies (video with transcript)- Feb 2021
Is Nutritional Yeast Healthy for Everyone? Dr. Greger

The Best Diet for Crohn’s Disease Treatment Video with transcript April 2021


Vitamin D levels OK months before Crohn's, but were low only after Crohn's


Crohn's and Colitis infographic

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39+ VitaminDWiki pages with CROHN in title

This list is automatically updated

Items found: 39
Title Modified
Crohn's and Vitamin D - many studies 29 Dec, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015 26 Mar, 2021
Crohn’s Disease reduced for a year by 7 weeks of high dose Vitamin D – RCT March 2021 26 Mar, 2021
Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013 09 Feb, 2021
Crohn's Disease 4X less likely to reoccur after surgery if good level of vitamin D – Feb 2021 09 Feb, 2021
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 12 Nov, 2019
Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019 28 Sep, 2019
Crohn’s Disease Activity predicted by vitamin D plus 2 additional blood tests – Dec 2018 07 May, 2019
Inflammatory Bowel Disease in children is associated with low Vitamin D, Iron (also low Zinc for Crohn’s) – Aug 2018 28 Aug, 2018
Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018 15 May, 2018
Crohn's patients with Vitamin D less than 30 ng were 1.8 X more likely to be readmitted within 1 year – April 2017 13 Mar, 2018
Crohn's disease in black children is worse in 6 ways – Dec 2015 10 Dec, 2017
Crohn's Disease flares 20 percent more likely if poor Vitamin D Binding Protein – Oct 2016 09 Nov, 2017
Crohn’s Disease risk increased 3 X if inadequate vitamin D level (another form is needed) – Oct 2017 12 Oct, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,0000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 16 Jul, 2017
Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017 15 Jul, 2017
Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015 31 Jan, 2017
Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015 11 Dec, 2016
Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015 14 Nov, 2016
Crohn’s disease associated with low vitamin D, unless in remission (22 vs 28ng)– Dec 2015 30 Jul, 2016
Is vitamin D supplementation a viable treatment for Crohn's disease – Nov 2015 18 Nov, 2015
Infliximab reduction of inflammation (Crohn’s) greatly aided by Vitamin D – Sept 2015 12 Sep, 2015
Crohn's disease treated by Vitamin D - RCT June 2015 07 Aug, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Crohn’s helped by 5000 IU vitamin D – April 2013 17 Feb, 2015
Crohn’s Disease – strange things such as no change of vitamin D levels with season – Dec 2014 09 Dec, 2014
Surgery for Crohn's disease 2X less likely if managed to raise vitamin D above 30 ng – May 2013 06 May, 2014
Active Crohn's disease is associated with low vitamin D levels – Feb 2013 14 Feb, 2013
About 40 percent more likely to get Crohn’s Disease or UC if have low vitamin D – March 2012 03 Nov, 2012
More than half those with Crohn’s disease have less than 20ng of vitamin D – March 2012 03 Nov, 2012
Even 800 IU vitamin D improved Crohn’s disease bone density – June 2012 03 Jul, 2012
Crohn's disease kids are 2X more likely to have low vitamin D, intervention helps – April 2012 12 Jun, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
Crohn’s Disease strongly associated with low vitamin D in South Asians – March 2012 29 Mar, 2012
Extra Vitamin D needed for Crohns 14 Mar, 2012
Crohn’s relapse reduced from 29% to 13% by taking 1200 IU of D3 – May 2010 04 Apr, 2011

15 gut questions and answers – NYT Feb 2023

The Wild World Inside Your Gut
Questions

  • 1 How can I tell if my gut is healthy? And what are some warning signs that it isn’t?
  • 2 How does my gut affect the rest of my body?
  • 3 What are some simple things I can do to improve my gut health?
  • 4 Are there any foods I should limit for the sake of my gut health?
  • 5 I often feel heartburn after I eat. Why is that and what can I do to stop it?
  • 6 Am I at risk for an ulcer if I am constantly stressed and eat a lot of spicy food?
  • 7 What is ‘leaky gut syndrome’ and how do I know if I have it?
  • 8 Can refined carbs like sugar or white flour cause an overgrowth of yeast in my gut?
  • 9 Are antibiotics bad for my gut health? And if so, what can I do to prevent the damage?
  • 10 I’ve seen a lot of ads for colon cleanses. What are they and should I do one?
  • 11 So what should I do to take care of my colon?
  • 12 What can the shape, type and frequency of my stool tell me about my health?
  • 13 If I see identifiable foods in my stool, does that mean I have a food intolerance?
  • 14 What actually works to prevent constipation?
  • 15 If I use over-the-counter laxatives, will my gut build up a tolerance or become dependent on them?

 Answers inside PDF

Overview Gut and vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
19265 NYT Gut.pdf admin 22 Feb, 2023 120.09 Kb 262
19178 Celiac Vit D, VDR meta.pdf admin 07 Feb, 2023 1.31 Mb 267
10941 IBD vs IBS.jpg admin 01 Dec, 2018 29.38 Kb 9247
10469 Crohn's and Colitis.jpg admin 03 Sep, 2018 175.61 Kb 5850
9421 Colon Diseases.jpg admin 27 Feb, 2018 28.14 Kb 5841
7385 Optimal vitamin D levels in Crohn’s disease - a review.pdf admin 24 Nov, 2016 1.40 Mb 1610
5307 Cannabis Crohn's.pdf admin 14 Apr, 2015 465.15 Kb 2436
5212 1987.jpg admin 22 Mar, 2015 87.79 Kb 6768
5211 Poor D2 absorption if poor gut - 1987.pdf admin 22 Mar, 2015 1.29 Mb 2034
4125 CD and low vitamin D July 2014.pdf admin 10 Jul, 2014 593.50 Kb 2669
3618 IBS Vitamin D Council.jpg admin 15 Feb, 2014 477.02 Kb 11593
3604 IBD - Feb 2014.pdf admin 08 Feb, 2014 3.92 Mb 4254
2654 intestinal-microflora-gut-floria-health.jpg admin 26 Jun, 2013 37.90 Kb 11958