Overview Gut and vitamin D

High level of vitamin D/UV reduces the risk of many gut problems
Many gut problems result in less absorption of Vitamin D & Magnesium . . .
Not restoring Vitamin D levels increases the risk of many other diseases
Increasing Vitamin D reduces many inflammations - incude those of the gut
Many companies make gut-friendly forms of vitamin D
- Topical nanoemulsion gut not needed
- Nanoemulsion
- Topical gut not needed
- Patch gut not needed
- Calcidiol gut not need to digest fat
- Liposomal not need to digest fat

Gut Summary

Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
Review in Nov 2013 found that Vitamin D helped
- Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
All items in category gut and vitamin D items

There are many ways to get vitamin D to people with poor guts
- There is a low-cost form of vitamin D designed for use with gut problems

See VitaminDWiki (other than Crohn's)

9 gut problems - in order of prevelance - Perplexity AI June 2024

Irritable Bowel Syndrome (IBS) - Affects 12% of the US population, making it the most common digestive disorder.
Gastroesophageal Reflux Disease (GERD) - Along with IBS, GERD is noted as one of the digestive disorders seeing a noticeable rise in incidence.
Constipation - Chronic constipation affects 15-30% of Canadians and is especially common in young children and the elderly.
Inflammatory Bowel Disease (IBD) - IBD, which includes Crohn's disease and ulcerative colitis, had an estimated 4.9 million prevalent cases globally in 2019.
Gastritis - Inflammation of the stomach lining, commonly caused by H. pylori infection, NSAIDs, or alcohol.
Peptic Ulcers - Often associated with gastritis and caused by H. pylori infection or NSAID use.
Pancreatitis - Had an estimated 2.41 million prevalent cases globally in 2019.
Appendicitis - Had an estimated 0.67 million prevalent cases globally in 2019.
Paralytic Ileus and Intestinal Obstruction - Had an estimated 0.55 million prevalent cases globally in 2019.

4 gut problems are associated with low vitamin D levels - Perplexity AI June 2024

Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis:
- Vitamin D deficiency is more common among those with IBD.
- Lower vitamin D levels are associated with higher disease activity and severity in Crohn's disease.
- Vitamin D deficiency may be implicated in the etiology and severity of IBD.
- Individuals with higher serum vitamin D have a lower incidence of IBD, particularly Crohn's disease.
Constipation:
- A study found that patients with chronic functional constipation and intestinal motility disorders had lower vitamin D levels compared to healthy controls.
- Low vitamin D levels were significantly correlated with constipation symptoms and impaired quality of life in these patients.
Diarrhea:
- Low vitamin D levels are associated with an increased risk of rotaviral diarrhea in children under 5 years old.
- A study found lower vitamin D levels in children with acute bacterial diarrhea compared to healthy children.
General Gastrointestinal Inflammation:

Vitamin D plays a role in maintaining gastrointestinal barrier integrity, regulating gut microbiota, and modulating inflammatory immune responses, which are important in preventing and ameliorating gut inflammation.

References

87% of eating disorders got worse with COVID-19 - Aug 2020

Exploring the impact of the COVID-19 pandemic and UK lockdown on individuals with experience of eating disorders

UK study, FREE PDF

Many gut diseases will do better with gut-friendly forms of Vitamin D

Getting Vitamin D into your blood and cells has the following chart

Getting Vitamin D into your blood and cells also has the following {include}

Review of IBD and Vitamin D (generally < 1,000 IU) - Feb 2014

Review of observational and intervention studies

Download the PDF from VitaminDWiki

SBI can help Colitis - Aug 2022

SBI = Serum-Derived Bovine Immunoglobulin/Protein Isolate,

by Eugene Heyden

IBS vs IBD

Colon Diseases

Celiac

Celiac associated with both low vitamin D and poor Vitamin D Receptor - meta-analsys - Feb 2023

A meta-analysis suggests the association of reduced serum level of vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin D receptor gene with celiac disease

Front Nutr . 2023 Jan 19;9:996450. doi: 10.3389/fnut.2022.996450

Tanya Shree 1, Pratibha Banerjee 1, Sabyasachi Senapati 1

Purpose: As an immune-modulator, vitamin D is known to regulate immune response and is implicated in disease pathogenesis. Celiac disease (CD) is a systemic autoimmune disease and susceptibility conferred by vitamin D metabolism is under investigation. Studies on the association of vitamin D metabolism and genetic polymorphisms are expected to explain CD pathogenesis. We performed a systematic review-based meta-analysis to investigate the 25(OH)D serum levels and susceptibility conferred by the genetic variants of VDR in CD.

Methods: Systematic review was conducted through a web-based literature search following stringent study inclusion-exclusion criteria. The Newcastle-Ottawa Scale and GRADE tools were used to assess the quality of evidence in studies and the study outcome. Cohen's κ value was estimated to access the reviewer's agreement. RevMan 5.4.1 was used to perform the meta-analyses. Weighted mean difference and Meta p-value was assessed for 25(OH)D serum levels. Meta-odds ratio and Z-test p-value were evaluated to estimate the allelic susceptibility of VDR variants.

Results: A total of 8 out of 12 studies were evaluated for "25(OH)D" serum level, while four studies were found eligible for SNPs (Bsm1, Apa1, Fok1, and Taq1) of VDR. Significantly higher levels [WMD = 5.49, p < 0.00001] of 25(OH)D were observed in healthy controls than in patients with CD. rs2228570-T (Fok1) [Meta-OR = 1.52, p = 0.02] was confirmed to be predisposing allele for CD.

Conclusion: Reduced serum level of 25(OH)D and association of Fok1 T-allele of VDR confirmed in this study plays a critical role in immunomodulation and maintaining barrier integrity, which is majorly implicated in CD.

Download the PDF from VitaminDWiki

Celiac disease is the most common genetic disease in Europe.

In Italy about 1 in 250 people and in Ireland about 1 in 300 people have celiac disease.

from http://www.wrongdiagnosis.com/c/celiac_disease/prevalence.htm

Celiac Disease is similar to Crohn's Disease in that both decrease vitamin D which can be absorbed in the gut

Celiac Disease may be similar to Crohn's Disease on the following chart

Does Gluten-Free Diet Protect Children with Celiac Disease from Low Bone Density? - Aug 2014

Download the PDF from VitaminDWiki.

They believe: CD ==> poor absorption ==> low vitamin D ==> low Bone Mineral Density

They conclude that if teen with CD has bone pain should have DXA test of BMD, then might consider giving vitamin D.

8 ✻ VitaminDWiki pages with CELIAC in title

Crohn's

Crohn's reduced by plant-based diet - Dr. Greger

Crohn's reactions to yeast, milk, eggs - good video review of many studies (video with transcript)- Feb 2021

Is Nutritional Yeast Healthy for Everyone? Dr. Greger

The Best Diet for Crohn’s Disease Treatment Video with transcript April 2021

Vitamin D levels OK months before Crohn's, but were low only after Crohn's

Presented at a medical conference June 2018 Military

Crohn's and Colitis infographic

39+ VitaminDWiki pages with CROHN in title

15 gut questions and answers – NYT Feb 2023

The Wild World Inside Your Gut

Questions

1 How can I tell if my gut is healthy? And what are some warning signs that it isn’t?
2 How does my gut affect the rest of my body?
3 What are some simple things I can do to improve my gut health?
4 Are there any foods I should limit for the sake of my gut health?
5 I often feel heartburn after I eat. Why is that and what can I do to stop it?
6 Am I at risk for an ulcer if I am constantly stressed and eat a lot of spicy food?
7 What is ‘leaky gut syndrome’ and how do I know if I have it?
8 Can refined carbs like sugar or white flour cause an overgrowth of yeast in my gut?
9 Are antibiotics bad for my gut health? And if so, what can I do to prevent the damage?
10 I’ve seen a lot of ads for colon cleanses. What are they and should I do one?
11 So what should I do to take care of my colon?
12 What can the shape, type and frequency of my stool tell me about my health?
13 If I see identifiable foods in my stool, does that mean I have a food intolerance?
14 What actually works to prevent constipation?
15 If I use over-the-counter laxatives, will my gut build up a tolerance or become dependent on them?

Answers inside PDF