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Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies

Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin - March 2016

Biomol Ther (Seoul). 2016 Mar 1;24(2):191-8. doi: 10.4062/biomolther.2015.122.
Lee KY1, Choi HS2,3, Choi HS3, Chung KY4, Lee BJ1, Maeng HJ5, Seo MD2,3.

The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various physiological activities such as calcium homeostasis, bone mineralization, and cell differentiation. Quercetin is a widely distributed flavonoid in nature that is known to enhance transactivation of VDR target genes. However, the detailed molecular mechanism underlying VDR activation by quercetin is not well understood. We first demonstrated the interaction between quercetin and the VDR at the molecular level by using fluorescence quenching and saturation transfer difference (STD) NMR experiments. The dissociation constant (Kd) of quercetin and the VDR was 21.15 ± 4.31 µM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR. The binding mode of quercetin was investigated by a docking study combined with molecular dynamics (MD) simulation. Quercetin might serve as a scaffold for the development of VDR modulators with selective biological activities.
 Download the 2016 PDF from VitaminDWiki

Vitamin D Receptor category has the following

507 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (35 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

VitaminDWiki pages containing QUERCETIN in the title

Items found: 11

See also web

Web Mercola
Foods containing quercetin Quercetin
(mg/100g of edible portion)
red kidney beans, raw (powdered) 603 +/- 307
capers, raw 234
capers, canned 173
lovage 170
dock like sorrel 86

Found My Fitness Aug 2020 table of contents (the words Receptor and Vitamin do not occur once)

2Quercetin and health
3Quercetin as an antioxidant
4Quercetin and inflammation
5Quercetin and chronic diseases
 5.1Quercetin and cardiovascular disease
 5.2Quercetin and hypertension
 5.3Quercetin and atherosclerosis
 5.4Quercetin and obesity
6Quercetin and wound healing
 6.1Quercetin and viral infections
 6.2Quercetin and rheumatoid arthritis
7Quercetin and exercise
8Quercetin and aging
9Senolytic compounds
10Quercetin as a senolytic compound
 10.1The "hit and run" treatment of senolytics
 10.1Quercetin improves median lifespan in animals
 10.2Quercetin improves age-related vascular conditions
 10.3Quercetin and neurological diseases
 10.4Quercetin and bone loss
 10.5Quercetin and pulmonary fibrosis
 10.6Quercetin and diet-related kidney disease
12Quercetin bioavailability and safety profile

23 studies cited this Quercetin - VDR study as of Oct 2023

  • Quercetin activates vitamin D receptor and ameliorates breast cancer-induced hepatic inflammation and fibrosis- April 2023 https://doi.org/10.3389/fnut.2023.1158633 FREE PDF
  • Role of in vitamin D in irritable bowel syndrome - April 2023 doi: 10.12998/wjcc.v11.i12.2677 FREE PDF

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Created by admin. Last Modification: Thursday October 5, 2023 10:26:29 GMT-0000 by admin. (Version 41)
Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies        
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ID Name Comment Uploaded Size Downloads
20184 health-benefits-of-quercetin-pdf Oct 2023.pdf admin 05 Oct, 2023 205.42 Kb 44
8033 Risk of prostate cancer Q.pdf admin 28 May, 2017 236.98 Kb 945
7333 Quercetin help VDR.pdf admin 14 Nov, 2016 3.51 Mb 1134