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Sudden kidney infection in children was 9X more likely if poor Vitamin D receptor – July 2018

Sudden kidney infection = acute pyelonephritis was mentioned in the following

Image
It is amazing that this huge increase was not mentioned in the title nor abstract

Vitamin D receptor gene (FokI, TaqI, BsmI, and ApaI) polymorphisms in children with urinary tract infection
Abolfazl Mahyar, Parviz Ayazi, Arshnoos Sarkhosh Afshar, Taghi Naserpour Farivar, Mehdi Sahmani, Sonia Oveisi, Robabeh Shabani & Shiva Esmaeili
Pediatric Research (2018) , https://doi.org/10.1038/s41390-018-0092-y

Background: Little is known about the genetic background of urinary tract infection (UTI) in children.

Methods: In this study, vitamin D receptor (VDR) gene polymorphisms were compared between 60 children with UTI (case group) and 60 healthy children (control group). DNA extraction, polymerase chain reaction, and the restriction fragment length polymorphism methods were used to perform the genetic analysis.

Results
There was a significant difference between the case and control groups for VDR gene, ApaI and Bsml, polymorphisms (P < 0.05). The frequency of VDR Bb, bb, Aa, and aa genotypes, and the b and a alleles in the case group was significantly higher than that in the control group (P < 0.05). A significant difference was also found between lower UTI and acute pyelonephritis groups for the VDR Apal and Bsml genotypes (P < 0.05). There was no significant difference between children with first UTI and those with more than one UTI for VDR gene polymorphisms (P > 0.05).

Conclusion
This study showed that there is a significant relationship between VDR gene, Apal and Bsml, polymorphisms and UTI in children. The results indicate that these polymorphisms may play a role in pathogenesis of UTI.


PDF mentions findings from many other VDR studies, such as

Lower RTI 7 X more likely with FokI FF genotype


Vitamin D Receptor category page in VitaminDWik has the following

217 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 41 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDR
Costs less than 1 cent per day
Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
28Leprosy
13Sepsis
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis



Created by admin. Last Modification: Friday July 6, 2018 21:52:27 UTC by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
10111 UTI VDR.jpg admin 06 Jul, 2018 20:45 44.35 Kb 10
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