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Ischemic Stroke is 18% more likely if poor Vitamin D genes (unless take more Vitamin D) – Feb 2024


Causal effect of serum 25 hydroxyvitamin D concentration on cardioembolic stroke: Evidence from two-sample Mendelian randomization

Nutrition, Metabolism, and Cardiovascular Disease :https://doi.org/10.1016/j.numecd.2024.02.013

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It seems that there are two groups of genes
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Highlights

  • Genetically predicted serum 25 hydroxyvitamin D concentration is associated with the risk of cardioembolic stroke.
  • Mendelian Randomization analysis provides suggestive evidence that increased 25(OH)D levels may play a protective role in the development of cardioembolic stroke.
  • Determining the role of 25(OH)D in stroke subtypes may be beneficial for the prevention of cardioembolic strokes.

Background and aims
The putative association between serum 25-hydroxyvitamin D concentration [25(OH)D] and the risk of cardioembolic stroke (CES) has been examined in observational studies, which indicate controversial findings. We performed Mendelian randomization (MR) analysis to determine the causal relationship of serum 25(OH)D with the risk of CES.

Methods and results
The summary statistics dataset on the genetic variants related to 25(OH)D was used from the published GWAS of European descent participants in the UK Biobank, including 417,580 subjects, yielding 143 independent loci in 112 1-Mb regions. GWAS summary data of CES was obtained from GIGASTROKE Consortium, which included European individuals (10,804 cases, 1,234,808 controls). Our results unveiled a causal relationship between 25(OH)D and CES using IVW [OR = 0.82, 95% CI: 0.67–0.98, p = 0.037]. Horizontal pleiotropy was not seen [MR-Egger intercept = 0.001; p = 0.792], suggesting an absence of horizontal pleiotropy. Cochrane's Q [Q = 78.71, p-value = 0.924], Rucker's Q [Q = 78.64, p-value = 0.913], and I2 = 0.0% (95% CI: 0.0%, 24.6%) statistic suggested no heterogeneity. This result remained consistent using different MR methods and sensitivity analyses, including Maximum likelihood [OR = 0.82, 95%CI: 0.67–0.98, p-value = 0.036], Constrained maximum likelihood [OR = 0.76, 95%CI: 0.64–0.90, p-value = 0.002], Debiased inverse-variance weighted [OR = 0.82, 95%CI: 0.68–0.99, p-value = 0.002], MR-PRESSO [OR = 0.82, 95%CI 0.77–0.87, p-value = 0.022], RAPS [OR = 0.82, 95%CI 0.67–0.98, p-value = 0.038], MR-Lasso [OR = 0.82, 95%CI 0.68–0.99, p-value = 0.037].

Conclusion
Our MR analysis provides suggestive evidence that increased 25(OH)D levels may play a protective role in the development of cardioembolic stroke. Determining the role of 25(OH)D in stroke subtypes has important clinical and public health implications.
 Download the preprint PDF from VitaminDWiki


23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title

This list is automatically updated

Items found: 23
Title Modified
Ischemic Stroke is 18% more likely if poor Vitamin D genes (unless take more Vitamin D) – Feb 2024 21 Mar, 2024
High Omega-3 reduced risk of Ischemic stroke by 18% - Dec 2023 05 Jan, 2024
Elderly vaccinated for COVID were 2X more likely to die of ischemic stroke (2930 vs 1180 deaths)– Nov 2021 22 Nov, 2021
Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016 05 Mar, 2021
Poor Ischemic stroke outcome (END) 2.6 X worse if low vitamin D – March 2019 26 Nov, 2019
Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019 02 May, 2019
Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018 29 Jun, 2018
Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018 28 Feb, 2018
Ischaemic Stroke has less impact in animals supplemented with Omega-3 – Jan 2018 13 Feb, 2018
Vitamin D levels drop after ischemic stroke – Dec 2017 20 Jan, 2018
Ischemic stroke 17 X more likely if low vitamin D – April 2017 13 Jan, 2018
Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017 04 Jan, 2018
Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017 27 Oct, 2017
Ischemic stroke and low vitamin D – 3X higher risk of poor outcome, 6 X higher risk of a second stroke, Oct 2017 04 Oct, 2017
Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017 01 Aug, 2017
Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017 01 Aug, 2017
Risk of Ischemic Stroke doubles if take more than 1 gram of Calcium daily for years – May 2017 20 May, 2017
Ischemic Stroke risk best predicted by Vitamin D, including PTH improves the prediction – Feb 2017 02 Mar, 2017
Ischemic Stroke with low vitamin D resulted in larger lesions – May 2015 11 Mar, 2016
Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012 12 Jul, 2015
Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014 29 Dec, 2014
Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014 17 Dec, 2014
Acute ischemic stroke 19 percent more likely if even lower vitamin D – Sept 2013 14 Sep, 2013

VitaminDWiki – Stroke category contains

122 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke

Attached files

ID Name Comment Uploaded Size Downloads
21006 Stroke bimodal bars.png admin 21 Mar, 2024 366.04 Kb 23
21005 Stoke Genes.png admin 21 Mar, 2024 360.56 Kb 28
21004 cardioembolic stroke - Mendelian_CompressPdf.pdf admin 21 Mar, 2024 1.31 Mb 17