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Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc


See also VitaminDWiki

It may be more important to test Vit. D Receptor than to test Vit. D blood level

Items in both categories Pregnancy and VDR are listed here:

Vitamin D Receptor category has the following

519 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

See other supplements and pregnancy

Assumptions: additional $50,000 per premature birth, $100 for education & supplements per pregnancy

Net savings
per birth
After subtract
all cost
# needed
to eliminate
1 preterm
Cost of
educ, supp
per pregnancy
Total cost
Cost of
test per
Net savings after
subtract costs
Vitamin D
(5,000 IU avg)
$4,30020$100$2,000$200%%%(2 tests)$4,000$43,000
Omega-3 $64667 $100$6,700$0 $0 $43,300
Vitamin C
reduces early rupture
$64667$100$6,700$0$0 $43,300
Iodine $320100$100$10,000$80$8,000$32,000

Does not include additional savings to infant beyond the first year
   such as reductions in Autism, MS, Respiratory Tract Infection, Asthma, Allergies
Does not include additional savings to mother
   such as reduction in preeclampsia, miscarriage, gestational diabetes, depression
   nor does it assign any costs for anguish of possible premie death, stillbirth, time off from work, job productivity
See Folic Acid in VitaminDWiki

See also preterm birth in VitaminDWiki

See also miscarriage in VitaminDWiki

Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019

see VitaminDWiki Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019

Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019

see VitaminDWiki Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019

VDR, spontaneous preterm birth and gestational diabetes– Feb 2018

Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects
Gene, Volume 642, 5 February 2018, Pages 58–63, https://doi.org/10.1016/j.gene.2017.10.087
N. Javorskia, b, C.A.D. Limaa, b, L.V.C. Silvac, S. Crovellaa, b, J. de Azêvedo Silvaa, b, ,

  • This is a new report relating polymorphisms within VDR gene and prematurity's outcomes.
  • Herein we correlate clinical characteristics and spontaneous preterm birth, according to the maternal VDR genotype.
  • Detection of direct relationship between VDR recessive genotype and specific clinical aspects in women with SPTB.

Preterm birth (PTB) is featured by less than 37 weeks of gestational age or fewer than 259 days since the first day from the last menstrual period. Complications of PTB are the major cause of neonatal deaths, several factors are linked to PTB increased risk including immunological and genetics. Vitamin D plays an important role in immune response modulation and its action occurs through the vitamin D receptor (VDR), which recently has been described as overexpressed in human placenta during the pregnancy. Herein we assessed two single nucleotide polymorphisms (SNPs) FokI (rs2228570 A > G) and Cdx-2 (rs11568820 T > C), within VDR, using TaqMan fluorogenic probes, and differential susceptibility to SPTB.
We assessed 104 pregnant women with SPTB and 85 women with normal birth in a Northeastern Brazilian population. Statistically significant differences for both SNPs where found when comparing allele and genotype frequencies in both groups: the T allele for rs2228570 and A allele for rs11568820 were significantly more frequent in SPTB group than in normal birth group (p = 0.000013 and p = 0.00466, respectively).
The rs11568820 A/A genotype was associated to clinical/demographic variables such as:

  • premature birth (p = 0.007),
  • neonate weight (p = 0.039),
  • presence of infection during pregnancy (p = 0.011) and
  • premature birth among multiparous (p = 0.015).

The rs2228570 T/T genotype associated with

  • gestational diabetes mellitus (p = 0.044) and
  • chorioamnionitis during pregnancy (p = 0.043).

In conclusion our findings indicate an association between polymorphisms FokI and Cdx-2 within VDR gene and SPTB, suggesting their involvement in the triggering of these syndromes.

PTB, Preterm birth; SPTB, Spontaneous preterm birth; PROM, Premature rupture of membranes; GDM, Gestational diabetes mellitus; VDR, Vitamin D receptor; TNF, Tumor necrosis factor; IL, interleukin; OR, Odds ratio; CI, Confidence interval
Publisher wants $36 for the PDF

 Download accepted manuscript PDF from SciHub VitaminDWiki

Preterm Birth 3.3X as likely if poor VDR – Aug 2016

Relationship between vitamin D receptor gene polymorphism and preterm birth. [Article in Chinese]
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Aug 20;36(9):1276-1280.
Cai W1, Shen XY, Zhu BP, Pan SL.

OBJECTIVE: To explore the relationship between vitamin D receptor (VDR) gene polymorphisms at Fok I site and the risk of preterm birth for potential intervention of of preterm birth or threatened premature delivery.

METHODS: Fifty-seven women with preterm birth and 84 with full-term birth were included in this analysis. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to identify VDR gene Fok I genotypes.

RESULTS: No significant difference was found in age, D-dimer (DDI), fibrinogen (Fg), serum calcium (Ca2+), leukocyte count or glycosylated hemoglobin (HbA1c) level between the women in the preterm and full-term birth groups (P>0.05). The two groups differed significantly in the distribution of VDR gene Fok I site genotypes and allele frequency of F/F (P<0.05).The frequency of FF genotype was significantly higher in the preterm group than in the full-term group. Compared with Ff and ff genotypes, FF genotype was associated with an increased risk of preterm delivery (χ2=9.701, P=9.701, OR=3.320, 95% CI [1.560, 7.066]). In the preterm group, the maternal age, DDI, Fg, serum Ca2+, leukocyte count or HbA1c did not differ significantly between the genotypes (P>0.05).

CONCLUSION: VDR gene Fok I site genotypes are related with preterm birth, and the FF genotype may serve as a potential risk factor for preterm birth.

PMID: 27687664

Preterm birth 34 X more likely if have worst VDR combination - Dec 2016

Influence of Apa1 (rs7975232), Taq1 (rs731236) and Bsm1 (rs154410) polymorphisms of vitamin D receptor on preterm birth risk in the Polish population.
Ginekol Pol. 2016;87(11):763-768. doi: 10.5603/GP.2016.0084.
Baczyńska-Strzecha M1, Kalinka J.
1Department of Perinatology, 1st Chair of Obstetrics and Gynecology, Medical University in Lodz, Poland. m.baczynska at onet.eu.

 Download the PDF from VitaminDWiki

Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy. The aim of this study was to evaluate the association between the parturients' Apa1, Taq1, and Bsm1 polymorphisms of the VDR and their combinations and the risk of preterm birth in the Polish population.

Determination of polymorphism for VDR was assayed using the RT-PCR method. 199 Caucasian women at childbirth were qualified:100 patients who had a spontaneous preterm birth and 99 patients who had a term birth.

Three separate genotypes of the Apa1, Taq1, and Bsm1 polymorphisms were detected. No significant differences in the frequency of particular genotypes in the compared groups were found. Some of the genotype combinations were significantly more frequent in the preterm group - the bb/AA/TT genotype (28.0% vs. 10.1%; p = 0.0013) and the BB/aa/tt genotype (14.0% vs. 4.04% p = 0.0277). The Bb/AA/Tt and the BB/Aa/tt genotypes were found only in the control group (16.1% and 7.0% of patients, respectively). The bb/aa/TT was significantly more frequent in the control group (2.0% vs. 11.1%; p = 0,0207).
Two genotype combinations reduced the risk of preterm birth - the

  • Bb/AA/Tt genotype by 94% (OR = 0.43, 95% CI: 0.002-0.885, p = 0.041) and the
  • BB/Aa/tt genotype by 98% (OR = 0.029, 95% CI: 0.001-0.838, p = 0.039).

Our result suggests that there may be a relationship between certain VDR genotype combinations and the risk of preterm birth. Further research is needed in order to substantiate this finding.

Preterm Birth twice as likely if poor VDR – Sept 2017

Asian Journal of Pharmaceutical and Clinical Research / academic sciences, Vol 10, Issue 9, 2017
department of Biochemistry, Shri A. N. Patel PG Institute, Sardar Patel University, Anand - 388 001, Gujarat, India. department of Gynecology and Obstetrics, Akanksha Hospital & Research Institute, Anand - 387 310, Gujarat, India. Email: hvphitesh at rediffmail.com

Objective: Preterm birth (PTB) is the leading cause of high infant mortality and long-term disability in young children worldwide. Array of adverse maternal and fetal outcomes linked with vitamin D level and its associated vitamin D receptor (VDR) gene. We undertook this study to investigate the association between VDR gene polymorphism with vitamin D deficiency and PTB in West Indian pregnant women.

Methods: A total of 72 women with PTB and 138 healthy mothers with uncomplicated normal delivery were selected from different regions of Gujarat, India. FokI and TaqI single nucleotide polymorphism (SNP) of VDR gene determined by polymerase chain reaction and restriction fragment length polymorphism. Vitamin D level was determined using enzyme-linked immunosorbent assay.

Result: ff genotype (29.17% vs. 10.87%, p=0.002) and f allele (49.31% vs. 35.51%, p=0.006) frequency distributions of VDR FokI showed significantly (odds ratio=0.566, 95% confidence interval=0.368-0.870, p=0.006) higher in women with preterm delivery than in control full term group. Genotype frequency of VDR TaqI showed no significant difference between preterm group and control.

Conclusion: These results confirmed that women carrying ff genotype of FokI gene had significantly higher risk for vitamin D deficiency which enhances the risk of prematurity than women carrying FF genotype in West Indian women.

 Download the PDF from VitaminDWiki

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Attached files

ID Name Comment Uploaded Size Downloads
8729 Vitamin D receptor (VDR) polymorphism.pdf admin 13 Nov, 2017 414.67 Kb 841
8727 VDR PTB.jpg admin 13 Nov, 2017 43.80 Kb 424
8380 VDR pre-term birth.pdf admin 02 Sep, 2017 519.04 Kb 880
7489 Preterm VDR Table 3.jpg admin 15 Dec, 2016 50.90 Kb 451
7488 Preterm VDR.pdf admin 15 Dec, 2016 135.63 Kb 1030