Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis.
Medicine (Baltimore). 2018 Jul;97(29):e11506. doi: 10.1097/MD.0000000000011506.
Zhang JZ1, Wang M2, Ding Y1, Gao F2, Feng YY1, Yakeya B1, Wang P1, Wu XJ1, Hu FX1, Xian J3, Kang XJ1.
1 Department of Dermatology.
2 Department of Gastroenterology.
3 Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
- Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis March 2016
- Spotty skin coloring (vitiligo) treated by augmenting topical tacrolimus with oral Vitamin D – Oct 2016
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018 -Note: Vitiligo is an auto-immune disease
Increased risk of Vitiligo if:
Low Vitamin D in blood
Poor Vitamin D Receptor which restricts Vitamin D getting to skin cells
Increase intake of Vitamin D
Increase VDR activation (see below)
Autoimmune category starts with
115 items in Autoimmune category
- see also category Lupus which has
54 items along with related searches
- see also category Psoriasis which has
47 items along with related searches
- Overview MS and vitamin D
- Overview Asthma and Vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Overview Diabetes and vitamin D
- Allergy - Overview
- Ankylosing spondylitis and low vitamin D – several studies
- Overview Gut and vitamin D IBD, Crohn's, etc
- Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D
See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:
- Wikipedia long list with details and accepted/suspected labels
- American Autoimmune Association very long list, click for details
- AutoImmuneDiseaseList Description of each of 100+ diseases
Examples: Lupus, Rheumatoid Arthritis, Psoriasis, Celiac, IBD, Anklosing spondylitis, Crohn's Disease, Type I Diabetes,
Vitamin D Receptor category has the following
230 items in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 45 health problems click here for details
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:
Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) Magnesium Vitamin D in the blood
AND to the cells
3) Omega-3 Vitamin D to the cells 4) Resveratrol Vitamin D to the cells 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR
Costs less than 1 cent per day
Vitamin D Receptor
If poor Vitamin D Receptor
Health Problem 28 Leprosy 13 Sepsis 9.6 Chronic Periodontitis
8 Juvenile Rheumatoid Arthritis 7.6 Crohn's disease 7.5 Respiratory Tract Infections 5.8 Low back pain in athletes 5 Ulcerative Colitis 5 Coronary Artery Disease 4.6 Breast Cancer 4.1 Vitiligo 4 polycystic ovary syndrome 3.6 Pneumonia - children 3.3 Pre-term birth 3.1 Colon Cancer survival 3 Multiple Sclerosis 3 Dengue 3 Waist size 3 Ischemic Stroke 3 Alzheimer’s 2.8 Osteoporosis & COPD 2.7 Gastric Cancer 2.6 Lupus in children 2.5 Lumbar Disc Degeneration 2.4 Lung Cancer 2.3 Autism 2.2 Juvenile idiopathic arthritis 2.1 Adolescent idiopathic scoliosis in Asians 2 Diabetic Retinopathy 2 Parkinson's 2 Wheezing/Asthma 2 Melanoma Non-melanoma Skin Cancers 2 Myopia 1.9 Uterine Fibroids 1.9 Early tooth decay 1.8 Diabetic nephropathy 1.6 Diabetes - Type I 1.6 Prostate Cancer while black 1.5 Diabetes -Type II 1.5 Pertusus 1.5 Obesity 1.4 Rheumatoid arthritis 1.3 Childhood asthma 1.3 Tuberculosis
OBJECTIVES: To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.
Databases including PubMed, Cochrane Library, Ovid, Web of Science, CNKI, SinoMed, and Wanfang Data were systematically searched. The association was assessed using odds ratios (ORs), standard mean difference (SMD), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.3.3.
We identified a total of 17 studies. The relationship between VDR gene polymorphisms (BsmI, ApaI, TaqI, and FokI), serum 25 (OH)D levels, and incidence of vitiligo was investigated. The results of this meta-analysis showed that the
- dominant genetic model (CC+AC vs AA, P = .007, OR = 1.41, 95% CI = 1.10-1.80),
- recessive genetic model (CC vs AC+AA, P = .01, OR = 4.10, 95% CI = 1.36-12.35), and
- allelic contrast model (C vs A, P = .005, OR = 1.87, 95% CI = 1.21-2.90)
- of VDR Apal locus increased the risk of vitiligo, and BsmI, TaqI, and FokI loci and the risk of vitiligo have no obvious correlation.
Serum 25 (OH)D deficiency was positively associated with the incidence of vitiligo (P < .0001, SMD = -0.94, 95% CI = -1.39, -0.48).
This meta-analysis revealed that VDR Apal polymorphism increased the susceptibility risk of vitiligo, and there is a positive correlation between serum 25 (OH)D deficiency and the incidence of vitiligo.
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- see also category Lupus which has