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Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018

Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis.

Medicine (Baltimore). 2018 Jul;97(29):e11506. doi: 10.1097/MD.0000000000011506.
Zhang JZ1, Wang M2, Ding Y1, Gao F2, Feng YY1, Yakeya B1, Wang P1, Wu XJ1, Hu FX1, Xian J3, Kang XJ1.
1 Department of Dermatology.
2 Department of Gastroenterology.
3 Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.

VitaminDWiki

Observation by Henry Lahore, Founder of VitaminDWiki

Increased risk of Vitiligo if:
Low Vitamin D in blood
AND/OR
Poor Vitamin D Receptor which restricts Vitamin D getting to skin cells
SOLUTIONS:
Increase intake of Vitamin D
Increase Sun/UVB
Increase VDR activation (see below)

Autoimmune category starts with

See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:

  • Wikipedia long list with details and accepted/suspected labels
  • American Autoimmune Association very long list, click for details
  • AutoImmuneDiseaseList Description of each of 100+ diseases
    Examples: Lupus, Rheumatoid Arthritis, Psoriasis, Celiac, IBD, Anklosing spondylitis, Crohn's Disease, Type I Diabetes,

Vitamin D Receptor category has the following

230 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 45 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDR
Costs less than 1 cent per day
Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
28Leprosy
13Sepsis
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4.1Vitiligo
4polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis

 Download the PDF from VitaminDWiki

OBJECTIVES: To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.

METHODS:
Databases including PubMed, Cochrane Library, Ovid, Web of Science, CNKI, SinoMed, and Wanfang Data were systematically searched. The association was assessed using odds ratios (ORs), standard mean difference (SMD), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.3.3.

RESULTS:
We identified a total of 17 studies. The relationship between VDR gene polymorphisms (BsmI, ApaI, TaqI, and FokI), serum 25 (OH)D levels, and incidence of vitiligo was investigated. The results of this meta-analysis showed that the

  • dominant genetic model (CC+AC vs AA, P = .007, OR = 1.41, 95% CI = 1.10-1.80),
  • recessive genetic model (CC vs AC+AA, P = .01, OR = 4.10, 95% CI = 1.36-12.35), and
  • allelic contrast model (C vs A, P = .005, OR = 1.87, 95% CI = 1.21-2.90)
  • of VDR Apal locus increased the risk of vitiligo, and BsmI, TaqI, and FokI loci and the risk of vitiligo have no obvious correlation.

Serum 25 (OH)D deficiency was positively associated with the incidence of vitiligo (P < .0001, SMD = -0.94, 95% CI = -1.39, -0.48).

CONCLUSION:
This meta-analysis revealed that VDR Apal polymorphism increased the susceptibility risk of vitiligo, and there is a positive correlation between serum 25 (OH)D deficiency and the incidence of vitiligo.

Created by admin. Last Modification: Tuesday July 31, 2018 16:24:29 UTC by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
10224 vitiligo VDR.pdf PDF 2018 admin 21 Jul, 2018 23:55 1.12 Mb 20
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