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Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021

Impact of Genetic Polymorphisms on the Metabolic Pathway of Vitamin D and Survival in Non-Small Cell Lung Cancer

Nutrients 2021, 13(11), 3783; https://doi.org/10.3390/nu13113783
by Laura Elena Pineda Lancheros 1ORCID,Cristina Pérez Ramírez 1,2,*,Almudena Sánchez Martín 1,José María Gálvez Navas 1,2ORCID,Fernando Martínez Martínez 3,María del Carmen Ramírez Tortosa 2ORCID andAlberto Jiménez Morales 1

  • 1 Pharmacy Service, Pharmacogenetics Unit, University Hospital Virgen de las Nieves, 18014 Granada, Spain
  • 2 Center of Biomedical Research, Department of Biochemistry and Molecular Biology II, Institute of Nutrition, and Food Technology “José Mataix”, University of Granada, Avda. del Conocimiento s/n., 18016 Granada, Spain
  • 3 Department of Pharmacy and Pharmaceutical Technology, Social and Legal Assistance Pharmacy Section, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain

Vitamin D has been associated with risk, development, and progression of cancer. However, the genes involved in its metabolism are highly polymorphic, compromising its activity. The aim of this study is to evaluate the association between the gene polymorphisms involved in the metabolic pathway of vitamin D and survival in patients with non-small-cell lung cancer (NSCLC). The study was designed as an observational cohort which included 194 Caucasians patients from southern Spain with NSCLC. Real-time polymerase chain reaction was used to analyze the following polymorphisms:

  • CYP27B1 rs4646536, rs3782130, and rs10877012;
  • CYP24A1 rs6068816 and rs4809957; GC rs7041;
  • CYP2R1 rs10741657;
  • VDR rs1544410 (BsmI), rs11568820 (Cdx-2), rs2228570 (FokI), rs7975232 (ApaI), and rs731236 (TaqI).

Progression-free survival (PFS) and overall survival were assessed. Cox regression showed that rs4646536 was associated with PFS in the general population (p = 0.0233) and in the non-resected NSCLC subgroup (p = 0.0233). In the resected NSCLC subgroup, rs11568820 was associated with OS (p = 0.0129) and rs7041 with PFS (p = 0.0447). In the non-resected NSCLC subgroup, rs6068816 was associated with PFS (p = 0.0048) and OS (p = 0.0089) and rs731236 and rs7975232 were associated with OS (p = 0.0005) and PFS (p = 0.0002), respectively. The other polymorphisms showed no effect on the results. The rs4646536, rs6068816, rs7041, rs11568820, rs731236, and rs7975232 polymorphisms are associated with survival in NSCLC and may have a substantial role as prognostic markers of the disease.







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Lung Cancer and Vitamin D Receptor

List is automatically updated

Some Lung Cancer and other gene studies

Cancers and CPY24A1

Cancers might alter CYP24A1 gene

CYP24B1 and gene chart

CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
Blood Test Misses a lot (VDW 3439)

Vitamin D Binding Protein (GC)
Vitamin D Binding Protein category listing has 169 items along with related searches
Vitamin D Receptor pages with CANCER in title (75 as of Oct 2021)

list is automatically updated

Vitamin D Receptor - # of diseases, how to fix a poor VDR

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

Created by admin. Last Modification: Thursday October 28, 2021 06:01:46 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
16488 LC supplement.zip admin 25 Oct, 2021 16:35 1.86 Mb 168
16487 LC Table 8.jpg admin 25 Oct, 2021 15:42 67.85 Kb 161
16486 LC Table 6.jpg admin 25 Oct, 2021 15:42 66.37 Kb 162
16485 Lung Cancer CYP24A1.jpg admin 25 Oct, 2021 15:42 16.07 Kb 139
16484 VDR table.jpg admin 25 Oct, 2021 15:41 25.39 Kb 160
16483 Lung Cancer VDR.jpg admin 25 Oct, 2021 15:41 17.59 Kb 153
16482 Lung Cancer CYP27B1.jpg admin 25 Oct, 2021 15:41 18.74 Kb 158
16481 Non-Small Cell Lung Cancer genes.pdf PDF 2021 admin 25 Oct, 2021 15:40 617.05 Kb 181