Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.
BMC Med Genet. 2017 Aug 22;18(1):90. doi: 10.1186/s12881-017-0454-z.
Bienertová-Vašků J1,2, Zlámal F3, Pohořalá A3, Mikeš O3, Goldbergová-Pávková M4, Novák J4, Šplíchal Z4, Pikhart H3,5.
- Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021
- Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020
- Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019
- Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Skin fold thickness but not BMI associated with poor Vitamin D Receptor in Han Chinese – April 2018
- Resveratrol improves health (Vitamin D receptor, etc.)
- Obesity might be related to Vitamin D genes – July 2018
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D Receptor and Obesity – several studies
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
|1) Vitamin D supplement|
Sun, Ultraviolet -B
| Vitamin D in the blood |
and thus in the cells
|2) Magnesium||Vitamin D in the blood |
AND in the cells
|3) Omega-3||Vitamin D in the cells|
|4) Resveratrol||Vitamin D Receptor|
|5) Intense exercise||Vitamin D Receptor|
|6) Get prescription for VDR activator|
|Vitamin D Receptor|
|7) Quercetin (flavonoid)||Vitamin D Receptor|
|8) Zinc is in the VDR||Vitamin D Receptor|
|9) Boron||Vitamin D Receptor ?, |
|10) Essential oils e.g. ginger, curcumin||Vitamin D Receptor|
|11) Progesterone||Vitamin D Receptor|
|12) Infrequent high concentration Vitamin D|
Increases the concentration gradient
|Vitamin D in the cells|
|13) Sulfroaphane and perhaps sulfur||Vitamin D Receptor|
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
If poor Vitamin D Receptor
There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.
A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.
In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (β = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (β = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (β = -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (β = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (β = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.
Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.
PMID: 28830368 PMCID: PMC5568207 DOI: 10.1186/s12881-017-0454-z
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