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Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016

The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis.

Biomed Res Int. 2016;2016:5305282. Epub 2016 Nov 6.
Zhang Y1, Xia W1, Lu P1, Yuan H1.
1Department of Endocrinology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

See also VitaminDWiki

Items in both categories Diabetes and Vitamin D Receptor are listed here:

Vitamin D Receptor category has the following

410 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Items in both categories Diabetes and Vision are listed here:

See also web

  • Wikipedia
    "also known as diabetic eye disease, is when damage occurs to the retina due to diabetes. It can eventually lead to blindness"
    "affects up to 80 percent of all patients who have had diabetes for 20 years or more"
    " It is also the leading cause of blindness for people aged 20 to 64 years."

 Download the PDF from VitaminDWiki

Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic.

Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association.

Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls). Pooled ORs showed a significant association between FokI polymorphism and DR risk in all the four genetic models (

  • OR = 1.612 (1.354~1.921),
  • 1.988 (1.481~2.668),
  • 1.889 (1.424~2.505), and
  • 2.674 (1.493~4.790)

in allelic, dominant, recessive, and additive models, resp., PZ < 0.01), but not for TaqI or BsmI polymorphism (PZ > 0.05). Similar results were found in the subgroup analysis. Sensitivity analysis indicated that the results were relatively stable and reliable. Results of Begg's and Egger's tests suggested a lack of publication bias.

Conclusions. Our meta-analysis demonstrated that DR was significantly associated with VDR gene FokI polymorphism. However, due to the relatively small sample size in this meta-analysis, further studies with a larger sample size should be done to confirm the findings.

PMID: 27891515 DOI: 10.1155/2016/5305282

Attached files

ID Name Comment Uploaded Size Downloads
7408 Diabetic Retinopathy VDR.pdf PDF 2016 admin 29 Nov, 2016 12:32 1.65 Mb 666
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