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Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022

Relationship Between Vitamin D Receptor Gene BsmI Polymorphism and Fibromyalgia Syndrome

Cureus . 2022 Jul 21;14(7) doi: 10.7759/cureus.27113
Sidrah Parvez 1 , Ghizal Fatima 1 , Farzana Mehdi 2 , Najah R Hadi 3 , Jan Fedacko 4

Purpose Vitamin D receptor (VDR) has been proposed as a possible marker for fibromyalgia syndrome (FMS). The purpose of this study is to characterize the expression pattern of BsmI polymorphism (rs1544410) in the VDR gene in women with FMS and the genotype-phenotype association.

Methods A total of 105 FMS patients and 105 controls were included in this study. VDR gene BsmI polymorphism was assessed by polymerase chain reaction (PCR) and restriction fragment length polymerase (RFLP) method.

Results There was no significant difference in the frequency distribution of both genotypes and alleles for VDR gene BsmI polymorphism between FMS patients and controls (p>0.05). The frequencies of BB, Bb, and bb in the VDR gene BsmI polymorphism were 19%, 43%, and 37% in patients, while in controls were 22.9%, 55.2%, and 21.9%. However, we did not find any significant association between the clinical symptoms of this disease and VDR BsmI genotypes among FMS patients (p>0.05).

Conclusions The relationship between the VDR gene BsmI polymorphism and FMS could not be determined in this study. However, further studies with a larger sample size may be required to show a relation between the VDR gene BsmI polymorphism and FMS.
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Note: Trial was to small for the statistics to reach statistical significance

See also in VitaminDWiki - Overview Fibromyalgia or Chronic Fatigue and vitamin D

VitaminDWiki pages with "Chronic Fatigue" OR Fibromyalgia in title (37 as of Aug 2022)

This list is automatically updated

Items found: 33
Title Modified
SSRI Drugs Can Cause Chronic Fatigue Syndrome - Mercola April 2024 19 Apr, 2024
Fibromyalgia pain, fatigue, etc. reduced by 50,000 IU of Vitamin D for 12 weeks – Sept 2023 04 Oct, 2023
Vitamin D at CureTogether: Fibromyalgia, MS, Psoriasis, etc - Dec 2013 11 Jul, 2023
Overview Fibromyalgia or Chronic Fatigue and vitamin D 11 Jul, 2023
Chronic Fatigue Syndrome and long-haul COVID-19 26 Sep, 2022
Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022 24 Aug, 2022
Fibromyalgia and Musculoskeletal Pain treated by raised Vitamin D levels – July 2022 23 Jul, 2022
Epstein Barr Virus and Chronic Fatigue Syndrome 13 Dec, 2021
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 19 Oct, 2019
Fibromyalgia severity associated with serotonin but not Vitamin D (almost all were insufficient) – May 2019 27 May, 2019
Fibromyalgia associated with low vitamin D, more studies needed – review Dec 2018 15 Oct, 2018
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 23 Jun, 2018
Chronic Fatigue Syndrome reduced by D-Ribose – 2012 07 May, 2018
Fibromyalgia associated with lower Vitamin D – meta-analysis Oct 2017 10 Feb, 2018
Fibromyalgia benefits from transdermal magnesium chloride – Sept 2015 09 Aug, 2017
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – Nov 2016 27 Jun, 2017
Fibromyalgia helped by Vitamin D – still not sure how much, and why - June 2016 31 Dec, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 27 Jul, 2016
Fibromyalgia development 1.9 X more likely if low vitamin D – Jan 2016 20 Jan, 2016
Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 05 Nov, 2015
Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 15 Jul, 2015
Chicago Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 15 Jul, 2015
High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015 11 Jul, 2015
Overlap between Fibromyalgia and other Chronic Pains – 2012 11 Jan, 2015
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 22 Nov, 2014
Rheumatoid arthritis associated with low vitamin D – Fibromyalgia makes it even lower – Oct 2014 08 Oct, 2014
7100 IU vitamin D (50,000 weekly) significantly reduced fibromyalgia – 2009 20 Jan, 2014
Chronic Fatigue and Vitamin D insight – Jan 2014 12 Jan, 2014
Literature review of Fibromyalgia and vitamin D – Sept 2011 18 Dec, 2013
Fibromyalgia patients with low vitamin D have more pain – Dec 2013 18 Dec, 2013
Chronic Fatigue Syndrome reduced with 25,000 IU of vitamin D weekly – June 2013 22 Nov, 2013
No rise in vitamin D levels of fibromyalgia patients in the summer – Sept 2013 08 Sep, 2013
Hypothesis – vitamin D will decrease chronic inflammation and fatigue – Oct 2010 13 Jul, 2013

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
9X in women
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

Created by admin. Last Modification: Friday January 5, 2024 13:18:27 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
18318 Fibro VDR Diseases.jpg admin 24 Aug, 2022 81.43 Kb 240
18317 Fibromyalgia VDR.pdf admin 24 Aug, 2022 102.39 Kb 173