Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012

Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

Genetic Testing and Molecular Biomarkers – Nov 2012
Rui-Fen Sun,2,* Qun-Hui Li,1 Da-Xing Wang,1 Feng Zhao,1 Jun-Min Li,1 Qi Pu,1 Zhong-Zi Zhang,1 Yan Jin,1 Bai-Lian Liu,1 and Ying Xiong1
1 Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.
2 Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, People's Republic of China.
Address correspondence to: Bai-Lian Liu, M.D.; Department of Orthopedics, Kunming Medical University. National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051
People's Republic of China, E-mail: 1628322036 at qq.com
Ying Xiong, M.D.; Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051, People's Republic of China. E-mail: xiongying789 at 126.com

Objective: Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.

Methods: Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (Cis).

Results: The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (

• bb vs. BB: OR=0.61, 95% CI, 0.40–0.92;
• bb vs. BB/Bb: OR=0.70, 95% CI, 0.52–0.95, respectively).

Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in

• postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46–0.98) and
• Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09–0.37).

Conclusion: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.
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PDFs of paper and supplemental data are at bottom of this web page

Forest plot of the meta-analysis (bb vs. BB)

Blacks are particularly affected (supp table 2)

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See also VitaminDWiki

• Overview Osteoporosis and vitamin D
• All items in category Bone - Osteoporosis 222 items
• All items in category Genetics and vitamin D 344 items
• Search VitaminDWiki for Bsmi 192 items as of Dec 2016
• Search VitaminDWiki for Bsmi AND Osteoporosis 92 items as of Dec 2016

Vitamin D Receptor category has the following

531 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (14 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR