Loading...
 
Translate Register Log In Login with facebookLogin and Register

Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012

Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

Genetic Testing and Molecular Biomarkers – Nov 2012
Rui-Fen Sun,2,* Qun-Hui Li,1 Da-Xing Wang,1 Feng Zhao,1 Jun-Min Li,1 Qi Pu,1 Zhong-Zi Zhang,1 Yan Jin,1 Bai-Lian Liu,1 and Ying Xiong1
1 Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.
2 Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, People's Republic of China.
Address correspondence to: Bai-Lian Liu, M.D.; Department of Orthopedics, Kunming Medical University. National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051
People's Republic of China, E-mail: 1628322036 at qq.com
Ying Xiong, M.D.; Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051, People's Republic of China. E-mail: xiongying789 at 126.com

Objective: Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.

Methods: Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (Cis).

Results: The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (

  • bb vs. BB: OR=0.61, 95% CI, 0.40–0.92;
  • bb vs. BB/Bb: OR=0.70, 95% CI, 0.52–0.95, respectively).

Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in

  • postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46–0.98) and
  • Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09–0.37).


Conclusion: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.
– – – – – – – – – –
PDFs of paper and supplemental data are at bottom of this web page

Forest plot of the meta-analysis (bb vs. BB)

Image

Blacks are particularly affected (supp table 2)

Image


See also VitaminDWiki

Vitamin D Receptor category has the following

265 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 51 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation.
You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

Attached files

ID Name Comment Uploaded Size Downloads
1761 BB supp_table2.pdf admin 30 Nov, 2012 16:02 27.13 Kb 1001
1760 Sup table 2.jpg admin 30 Nov, 2012 16:01 73.18 Kb 1086
1759 bb.jpg admin 30 Nov, 2012 16:01 61.98 Kb 1349
1758 BB supp_table1.pdf admin 30 Nov, 2012 16:01 30.54 Kb 860
1757 Vitamin D genes and osteoporosis - Nov 2012.pdf PDF admin 30 Nov, 2012 16:00 219.39 Kb 1683
See any problem with this page? Report it (FINALLY WORKS)