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Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012

Vitamin D Receptor BsmI Polymorphism and Osteoporosis Risk: A Meta-Analysis from 26 Studies

Genetic Testing and Molecular Biomarkers – Nov 2012
Rui-Fen Sun,2,* Qun-Hui Li,1 Da-Xing Wang,1 Feng Zhao,1 Jun-Min Li,1 Qi Pu,1 Zhong-Zi Zhang,1 Yan Jin,1 Bai-Lian Liu,1 and Ying Xiong1
1 Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.
2 Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, People's Republic of China.
Address correspondence to: Bai-Lian Liu, M.D.; Department of Orthopedics, Kunming Medical University. National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051
People's Republic of China, E-mail: 1628322036 at qq.com
Ying Xiong, M.D.; Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051, People's Republic of China. E-mail: xiongying789 at 126.com

Objective: Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.

Methods: Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (Cis).

Results: The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (

  • bb vs. BB: OR=0.61, 95% CI, 0.40–0.92;
  • bb vs. BB/Bb: OR=0.70, 95% CI, 0.52–0.95, respectively).

Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in

  • postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46–0.98) and
  • Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09–0.37).

Conclusion: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.
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PDFs of paper and supplemental data are at bottom of this web page

Forest plot of the meta-analysis (bb vs. BB)


Blacks are particularly affected (supp table 2)


See also VitaminDWiki

Vitamin D Receptor category has the following

420 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Attached files

ID Name Comment Uploaded Size Downloads
1761 BB supp_table2.pdf admin 30 Nov, 2012 16:02 27.13 Kb 1162
1760 Sup table 2.jpg admin 30 Nov, 2012 16:01 73.18 Kb 1338
1759 bb.jpg admin 30 Nov, 2012 16:01 61.98 Kb 1693
1758 BB supp_table1.pdf admin 30 Nov, 2012 16:01 30.54 Kb 1065
1757 Vitamin D genes and osteoporosis - Nov 2012.pdf PDF admin 30 Nov, 2012 16:00 219.39 Kb 1914
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