Association of vitamin D receptor gene variants with polycystic ovary syndrome: A case control study.
Int J Reprod Biomed (Yazd). 2015 Dec;13(12):793-800.
Mahmoudi T1, Majidzadeh-A K2, Farahani H3, Mirakhorli M4, Dabiri R5, Nobakht H5, Asadi A6.
- Fertility problem (PCOS) reduced by vitamin D: many studies
- Vitamin D and aspects of female fertility (especially PCOS) – May 2017
- PCOS treated by a combination of Vitamin D and Omega-3 – RCT Oct 2018
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 45 health problems click here for details
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
|1) Vitamin D supplement|
Sun, Ultraviolet -B
| Vitamin D in the blood |
and thus to the cells
|2) Magnesium||Vitamin D in the blood |
AND to the cells
|3) Omega-3||Vitamin D to the cells|
|4) Resveratrol||Vitamin D to the cells|
|5) Intense exercise||Vitamin D Receptor|
|6) Get prescription for VDR activator|
|Vitamin D Receptor|
|7) Quercetin (flavonoid)||Vitamin D Receptor|
|8) Zinc is in the VDR|
Costs less than 1 cent per day
|Vitamin D Receptor|
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation
You might feel the benefit within days of adding one or more of the above
If poor Vitamin D Receptor
|9.6||Chronic Periodontitis |
|8||Juvenile Rheumatoid Arthritis|
|7.5||Respiratory Tract Infections|
|5.8||Low back pain in athletes|
|5||Coronary Artery Disease|
|4||polycystic ovary syndrome|
|3.6||Pneumonia - children|
|3.1||Colon Cancer survival|
|2.8||Osteoporosis & COPD|
|2.6||Lupus in children|
|2.5||Lumbar Disc Degeneration|
|2.2||Juvenile idiopathic arthritis|
|2.1||Adolescent idiopathic scoliosis in Asians|
|2||Melanoma Non-melanoma Skin Cancers|
|1.9||Early tooth decay|
|1.6||Diabetes - Type I|
|1.6||Prostate Cancer while black|
|1.5||Diabetes -Type II|
Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.
The present study was designed to investigate the possible associations between polymorphisms in VDR, PTH, and INSR genes and the risk of PCOS.
MATERIALS AND METHODS:
VDR, PTH, and INSR gene variants were genotyped in 35 women with PCOS and 35 controls using Polymerase chain reaction - Restriction fragment length polymorphism method. Furthermore, serum levels of glucose and insulin were measured in all participants.
No significant differences were observed for the VDR FokI, VDR Tru9I, VDR TaqI, PTH DraII, INSR NsiI, and INSR PmlI gene polymorphisms between the women with PCOS and controls.
However, after adjustment for confounding factors, the VDR BsmI "Bb" genotype and the VDR ApaI "Aa" genotype were significantly under transmitted to the patients (p= 0.016; OR= 0.250; 95% CI= 0.081-0.769, and p= 0.017; OR= 0.260; 95% CI= 0.086-0.788, respectively). Furthermore, in the women with PCOS, insulin levels were lower in the participants with the INSR NsiI "NN" genotype compared with those with the "Nn + nn" genotypes (P= 0.045).
The results showed an association between the VDR gene BsmI and ApaI polymorphisms and PCOS risk. These data also indicated that the INSR "NN" genotype was a marker of decreased insulin in women with PCOS. Our findings, however, do not lend support to the hypothesis that PTH gene DraII variant plays a role in susceptibility to PCOS.
PMID: 27141540 PMCID: PMC4827506