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Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020

Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer

Saudi Journal of Biological Sciences, https://doi.org/10.1016/j.sjbs.2020.01.006
Ayat B.Al-GhafariabcKhadijah S.Balamasha1Huda A.Al Doghaithera2

VitaminDWiki

Note: Several Cancers have "learned" how to protect themselves from Vitamin D
After the cancer starts, it decreases the Vitamin D Receptor activation.
   Thus for some cancers: Cancer ==> poor VDR, rather than poor VDR ==> Cancer

Vitamin D Receptor and Cancers

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:


See also on web

  • Colorectal Cancer increased 6X for one form of Receptor problem - Sept 2020    PDF
    • TaqI and ApaI Variants of Vitamin D Receptor Gene Increase the Risk of Colorectal Cancer in a Saudi Population

 Download the PDF from VitaminDWiki
Image

Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity worldwide, and there has been a significant increase in the incidence of CRC in recent decades. Therefore, there is an urgent need to identify blood biomarkers that can be used for early diagnosis. It is not yet clear whether the level of vitamin D and its receptor, vitamin D receptor (VDR), in the blood are helpful factors in the diagnosis of CRC. Therefore, the study focuses on determining the VDR serum level’s contribution and other chemical parameters to the risk of CRC. A total of 189 Saudi participants (66 CRC patients and 123 control patients) aged 20-80 years old were enrolled in this case-control study. A serum sample was collected from each participant, and the levels of VDR and other bone profile tests were determined using ELISA or chemiluminescent assays. P values < 0.05 were considered statistically significant. The results showed a highly significant reduction in the levels of total vitamin D (P < 0.0001), VDR (P < 0.0001), vitamin D3 (P < 0.05), and calcium (P < 0.0001) in the serum of CRC patients compared to the controls. However, the alkaline phosphatase level was higher in CRC patients compared to the controls (P < 0.0001). None of the blood markers showed a significant correlation to the progression of CRC (P > 0.05). More investigation is needed to elucidate different physiological processes that can be affected by these blood biomarkers, therefore changing the carcinogenesis of CRC.


Created by admin. Last Modification: Tuesday September 22, 2020 12:08:01 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14355 VDR CC Sept 2020.pdf PDF 2020 admin 22 Sep, 2020 12:05 635.16 Kb 15
13380 VDR CRC.jpg admin 22 Jan, 2020 16:55 113.06 Kb 178
13379 VDR CRC.pdf admin 22 Jan, 2020 16:55 462.78 Kb 120
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