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Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021

Low vitamin D levels in follicular fluid, but not in serum, are associated with adverse outcomes in assisted reproduction

Arch Gynecol Obstet. 2021 Aug 8. doi: 10.1007/s00404-021-06174-9
Kahindo P Muyayalo # 1 2, Su Song # 3, Hui Zhai # 4, Hong Liu 1, Dong-Hui Huang 1, Hui Zhou 1, Yang-Jiao Chen 3, Ai-Hua Liao 5

Purpose: To assess the relationship between serum/follicular fluid (FF) vitamin D (VD) status and assisted reproductive technology (ART) treatment outcomes among infertile patients.

Methods: A prospective cohort study, including 132 infertile patients scheduled for their first ART treatment cycle, was carried out in a Reproductive Medical Center. Serum and FF samples were collected to assess 25-hydroxy VD [25(OH)D] levels. Low VD level was defined as 25(OH)D concentration of less than 30 ng/mL.

Results: Most infertile patients had low VD levels in serum (88%) and FF (90%). We observed a moderately positive correlation between VD levels in serum and FF (r = 0.34, p < 0.0001). Compared to the group of patients with low VD levels in the FF, those with sufficient VD levels had a significantly higher number of retrieved oocytes (p = 0.03), normal fertilization (p = 0.01), and high-quality embryos (p = 0.001). Moreover, patients with sufficient VD levels in the FF also had significantly higher implantation rates than those with low VD levels (76.92% vs. 46.58%, respectively, p = 0.01) and clinical pregnancy rates (92.31% vs. 61.54%, respectively, p = 0.04).

Conclusion: These data collectively revealed that low VD levels in serum and FF were common among infertile patients.

VD levels in FF, but not in serum, were associated with:
  • embryo quality,
  • normal fertilization,
  • implantation rates, and
  • clinical pregnancy rates.

Further studies are mandatory to determine the molecular mechanism and VD's potential therapeutic benefits in infertile patients.

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VitaminDWiki comments

In 2018 the founder of VitaminDWiki asked if it were technically possible to measure vitamin D levels in cells
In 2019 the question was asked again - and the answer then was yes, but it cost about 3X of the serum test
In 2021 most doctors and researchers still only rarely consider the cell levels of vitamin D
5 genes can restrict Vitamin D in the blood from actually getting to the cells
in Visio for 2023
The Vitamin D Receptor is perhaps the most important gene
   (the most likely to be deactivated AND the most easily reactivated)
Many diseases have "learned" how to protect themselves by deactivating the Vitamin D Receptor
Many Cancers for example
80-100 ng often gets Vitamin D to the cells even when there are gene restrictions
A normally good level of Vitamin D (e.g. 30 ng) can be restricted by genes however

Vitamin D Receptor category has the following

507 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (35 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

VitaminDWiki - Fertility and Sperm category contains

134 items in Fertility or Sperm in VitaminDWiki

See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles

VitaminDWiki - (Vitamin D greatly improves Fertility__

Increased male Vitamin D increases fertility

Decreased Fertility if decreased Vitamin D Receptor

VitaminDWiki pages with IVF or IN VITRO FERTILIZATION in title (13 as of April 2022)

This list is automatcially updated

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