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Phytochemicals (Quercetin, Resveratrol, Tumeric, etc.) plus Vitamin D – July 2023

Phytonutrients, also called phytochemicals or antioxidants,
   are compounds produced by plants that provide health benefits to the body

Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases - July 2023

Int J Mol Sci . 2023 Jul 29;24(15):12167. doi: 10.3390/ijms241512167.
Kazuki Santa 1, Kenji Watanabe 2 3, Yoshio Kumazawa 4 5, Isao Nagaoka 5 6

Table of Contents


Grape Randomized Controlled Trials
A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one category of the chemical compounds mainly known as antioxidants, and recently, their anti-inflammatory effects in preventing chronic inflammation have received much attention. Here, we present a narrative review of the health-promotion and disease-prevention effects of phytochemicals,
including polyphenols, the latter of which are abundant in

  • onions,
  • oranges,
  • tea,
  • soybeans,
  • turmeric,
  • cacao, and
  • grapes,
    • along with the synergetic effects of vitamin D.

A phenomenon currently gaining popularity in Japan is finding non-disease conditions, so-called ME-BYO (mibyou) and treating them before they develop into illnesses. In addition to lifestyle-related diseases such as metabolic syndrome and obesity, dementia and frailty, commonly found in the elderly, are included as underlying conditions. These conditions are typically induced by chronic inflammation and might result in multiple organ failure or cancer if left untreated. Maintaining gut microbiota is important for suppressing (recently increasing) intestinal disorders and for upregulating immunity. During the COVID-19 pandemic, the interest in phytochemicals and vitamin D for disease prevention increased, as viral and bacterial infection to the lung causes fatal inflammation, and chronic inflammation induces pulmonary fibrosis. Furthermore, sepsis is a disorder inducing severe organ failure by the infection of microbes, with a high mortality ratio in non-coronary ICUs. However, antimicrobial peptides (AMPs) working using natural immunity suppress sepsis at the early stage. The intake of phytochemicals and vitamin D enhances anti-inflammatory effects, upregulates immunity, and reduces the risk of chronic disorders by means of keeping healthy gut microbiota. Evidence acquired during the COVID-19 pandemic revealed that daily improvement and prevention of underlying conditions, in terms of lifestyle-related diseases, is very important because they increase the risk of infectious diseases. This narrative review discusses the importance of the intake of phytochemicals and vitamin D for a healthy lifestyle and the prevention of ME-BYO, non-disease conditions.
 Download the PDF from VitaminDWiki

Phytochemicals are produced by plants to fight off fungi, bacteria, virus and consumption by animals.

>50,000 phytochemicals are in many categories:
carotenoids and polyphenols
polyphenols: phenolic acids, flavonoids, stilbenes or lignans.
Flavonoids: anthocyanins, flavones, flavanones, isoflavones, and flavonols.
Flavanols: catechins, epicatechins, and proanthocyanidins.

Chart of Phytochemicals

Science Direct 2016

5 recent publications on Phytochemicals and Vitamin D

  • Editorial: Rising stars in nutrition and inflammation - April 2023 10.3389/fnut.2023.1197351 FREE PDF
  • Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D - July 2023 doi: 10.3390/ijms241512167 FREE PDF
  • Healthy Diet, Grape Phytochemicals, and Vitamin D: Preventing Chronic Inflammation and Keeping Good Microbiota - 2023 : https://doi.org/10.2174/1871530323666221017151705
  • Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies - June 2023 doi: 10.37349/etat.2023.00145 FREE PDF

VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

11+ VitaminDWiki pages with QUERCETIN in the title

This list is automatically updated

18+ VitaminDWiki pages with CURCUMIN in the title

This list is automatically updated

Turmeric for Chronic Pain - Green Med Info 2022

Does your active lifestyle leave you aching and inflamed, wishing there was an alternative to dangerous NSAID drugs? Wish no more — turmeric's got your pain covered

VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) contains

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
  • Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratrol
18 articles in both of the categories Resveratrol and Vitamin D Receptor

VitaminDWiki – Vitamin D Receptor category contains

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
9X in women
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

Is BHT a phytochemical? It fights many enveloped viruses

A Quick Look at BHT - Aug 2023 substack

  • "(A seemingly magic bullet for lipid-coated viruses with anti-aging properties)"

See Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Zoster, Epstein, Hepatitis, RSV) – March 2011

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Attached files

ID Name Comment Uploaded Size Downloads
19956 Phytochemicals.jpg admin 13 Aug, 2023 175.14 Kb 221
19954 Grapte Polyphenols RCT.jpg admin 13 Aug, 2023 148.09 Kb 150
19953 T1B.jpg admin 13 Aug, 2023 54.42 Kb 154
19952 T1A.jpg admin 13 Aug, 2023 168.73 Kb 159
19951 Phyto ToC.jpg admin 13 Aug, 2023 27.02 Kb 175
19950 Phytochemicals and Vitamin D_CompressPdf.pdf admin 13 Aug, 2023 662.37 Kb 229