J Ovarian Res. 2013 May 26;6(1):37.
Mohapatra S, Saxena A, Gandhi G, Koner BC, Ray PC.
INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.
OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.
MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.
RESULTS: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype.
Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4).
CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.
PDF is attached at the bottom of this page
Second study one month later (June 2013) is also attached at the bottom of this page
Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis PLOS ONE
- Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action. – 2014
- Ovarian cancer: more likely to survive if more vitamin D – Aug 2012
- Calcium and vitamin D appear to be among the few ways to prevent ovarian cancer – 2010
- Ovarian Cancer is somewhat associated with a reduction in 20 ng of vitamin D – Feb 2011
- Difference in Fok gene reduced response to vitamin D by 35 percent – Nov 2012
- All items in category Genetics and Vitamin D
- Search VitaminDWiki for Fok1 91 items as of Feb 2017
- Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017
Vitamin D Receptor category has the following
423 studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor.Example: Breast Cancer
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor VDR as of Oct 2019 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) Magnesium Vitamin D in the blood
AND in the cells
3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDROvarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013
6413 visitors, last modified 14 Dec, 2017,This page is in the following categories (# of items in each category)Vitamin D Receptor 423 Cancer - Ovarian 21
ID Name Comment Uploaded Size Downloads 2670 Ovarian June 2013.jpg admin 30 Jun, 2013 12:19 75.02 Kb 1316 2669 Polymorpth VDR Ovarian Cancer June 2013.pdf PDF 2013 admin 30 Jun, 2013 12:11 486.70 Kb 835 2539 Ovarian7.jpg admin 02 Jun, 2013 12:24 32.26 Kb 1547 2538 Ovarian6.jpg admin 02 Jun, 2013 12:24 31.67 Kb 1425 2524 35-Ovarian cancer vit D Mohapatra.pdf PDF 2013 admin 28 May, 2013 14:24 183.64 Kb 840