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Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013

Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population.

J Ovarian Res. 2013 May 26;6(1):37.
Mohapatra S, Saxena A, Gandhi G, Koner BC, Ray PC.

INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.

OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.

MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.

RESULTS: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype.
Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4).

CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.

PMID: 23705897


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PDF is attached at the bottom of this page


Second study one month later (June 2013) is also attached at the bottom of this page

Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis PLOS ONE

16% increase
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See also VitaminDWiki

Vitamin D Receptor category has the following

303 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 53 health problems  click here for details
The risk of 41 diseases at least double with poor Vitamin D Receptor as of July 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

Attached files

ID Name Comment Uploaded Size Downloads
2670 Ovarian June 2013.jpg admin 30 Jun, 2013 12:19 75.02 Kb 1063
2669 Polymorpth VDR Ovarian Cancer June 2013.pdf PDF 2013 admin 30 Jun, 2013 12:11 486.70 Kb 630
2539 Ovarian7.jpg admin 02 Jun, 2013 12:24 32.26 Kb 1212
2538 Ovarian6.jpg admin 02 Jun, 2013 12:24 31.67 Kb 1147
2524 35-Ovarian cancer vit D Mohapatra.pdf PDF 2013 admin 28 May, 2013 14:24 183.64 Kb 624
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