Omega-3 and Vitamin D separately and together help with Depression, Cardiovascular, Cognition, Pregnancy, Infant, Obesity, Mortality, Breast Cancer, . . .
The Omega-3 Effect
Everything you need to know about the supernutrient for living longer, happier, and healthier
Willian Sears, 2012 Amazon $6 Kindle
The Queen of Fats
Why Omega-3s were removed from the western diet and what we can do to replace them
Susan Allport, 2006, Amazon $19 kindle
- Aroma of food is stored in the fat.
- Certain fats are much more likely to go rancid than others and develop off flavors.
- Animals tend to store excess energy in fat.
- Linolenic acid in 10X less stable than linoleic acid: This form of Omega-3 has a short shelf life discovered 1952
- Israel is the top consumer (per person) of Linoleic acid in the world (30 grams), and have a high rate of heart attack, similar to the US, but with less meat.
- Greens are high in Omega-3
- Should have a low ratio of Omega-6 to Omega 3: US has a high ratio of 10, Sweden has 5, Japan has only 2
Japan have highest life expectancy AND highest Omega-3 consumption in the world (as well as a very high consumption of Vitamin K2)
- PUFA was the only way to describe all Omegas until 1964
- Ratios in foods: Flaxseed oil 0.2, Canola 2, Walnut 5, Corn 46
- Far less saturated fat in wild animals than domesticated (1968)
- Omega-3 reduced future heart attacks in Intervention clinical trial
Intervention trial with 11,000 people who already had a heart attack. DHA and EPA 850 mg or placebo.
Within 3 years 45% fewer Sudden Deaths due to subsequent heart attacks.
- Omega-3 promoters encounter even more resistance than do Vitamin D3 promoters
Economic resistance from the food industry (shelf life) only Omega-3, medical industry opposed to change: Omega-3 and D3
- Wonder – do Americans pay more on health care than they do on food?
Answer YES: 16% on health care and 10% on food - as % of disposable income or % of GDP Breakdown by income level
40 years ago the %s of O-3 and O-6 were almost reversed.
- The goal of eating a balanced diet without supplements no longer makes sense when our food is no longer balanced
- All items in category Omega-3 and Vitamin D (
349 ) items
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Schizophrenia relapses reduced 3X by Omega-3 – RCT Mar 2015
- Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks
- Omega-3 supplementation during pregnancy reduce early pre-term births (save 1500 USD per child) – Aug 2016
- Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017
- Omega-3 conference and 12 publications – Nov 2014
- Omega 3 increased by 60 percent the ACTIVE vitamin D in the blood – many studies
- Stillbirth rate typically 1 in 200, perhaps only 1 in 800 with Omega-3
- Vitamin D Cofactors in a nutshell by VitaminDWiki
- Type 2 Diabetes helped by Omega-3 and Vitamin D – Feb 2014
- Vitamin D and Omega-3 are the first focus of Global Nutrition and Health Alliance
- For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
- Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Omega-7 - in addition to Omega-3
- Consuming more monounsaturated fat increased vitamin D – Aug 2011 has the following
WikiPedia Good (more vitamin D into bloodstream)= much more BLUE than Green
Almonds and macadamia nuts are examples of good foods to take with vitamin D
- Simple review of >300 Omega-3 products, no mention about bioavailability 2021
- https://labdoor.com/rankings/vegan-omega-3 Labdoor 2017? VEGAN
- Omega-3 Chewable 957 items on Amazon July 2019
- Fish Oil Supplements – Omega-3 Benefits, Side Effects, Dosage & Best Brand
- Omega-3 Supplement Guide: What to Buy and Why Dec 2015 Healthline
Describes ~10 forms
- Fish Oil Review by Consumer Labs July 2019 (behind a paywall)
Consumer Labs offers a 5 day free trial
82 page excellent reportof 2017 had the following table of contents
Statins tended to cancel the benefits of Omega-3
Emulsiified forms had 3X to 8X more bioavailability when taken with low fat meal (no indication of bioavailability with high fat meal)
Discusses a huge number of health problems helped by Omega-3: arthritis, gout, ulcerative colitis, dry eye, colorectal cancer, weight loss due to chemotherapy, eye diseases, anxiety, stress, migraine headache, schizophrenia, epilepsy, reading skills, pregnancy, wheezing, cognition, muscle strength
Dose sizes ranged from 60 mg (children) to 1,460 mg/day
No difference noticed in prescription forms - other than price
- Omega-3 is vital for health, mail-in test is low cost and accurate $43 Fall 2016
- OmegaQuant has several tests
$55 for Omega-3 Index, $80 adds Omega-6/Omega-3 ratio + AA/EPA ratio + transfat index
They also have a Calculator - input your current index and goal index
-  Omega-3 LEF July 2018 PDF
- Vegan form of Omega-3 announced June 2015
- Frequently Asked Questions about DHA and Omega-3 Jan 2017
- Eating fish during pregnancy may boost baby's development, not impair it Medical News today Jan 2015
Omega-3 may counteract the inflammatory effect of mercury Children followed for 20 years
- 61 Health Benefits of Omega-3 Fatty Acids Green Med Info Jan 2012
- What’s in Your Fish Oil Supplements? New York Times Jan 2014
Includes reporting on results by LabDoor: accuracy, quality, etc of about 100 fish oil/mega-3 products
- THE HISTORY OF OMEGA 3 LiveStrong March 2011
Govt recommendations since 1995
- History of omega-3s since 1923
- TAKE OMEGA 3 UK, lots of reference
- Low omega-3 levels could explain why some children have reading problems Sept 2013
Every one of 493 of the UK kids with cognitive disabilities had low levels of Omega-3
PDF is attached at the bottom of this page
- Lard from pigs which never get outdoors has very little vitamin D
"Free range" lard has 500 IU vitamin D per teaspoon rare, but you can get it on the internet, etc
- Are Statin Drugs Killing The Health Benefits Of Omega-3 Fat? Green Info Jan 2013
discussion of BMC study published in Jan 2013: those taking statins to no get heat benefits of Omega-3 full text online
- 600 mg DHA allowed children underperforming in reading to sleep 1 more hour per night RCT March 2014
- Update on Essential Fats Suillivan, 2011 has the following graph
- Huge list of studies of benefits of Omega-3 - sorted by health problem Expertomega3
2. OMEGA-3 IN INFLAMMATORY PROCESSES - Obesity. Metabolic syndrome, Diabetes, Rheumatoid arthritis, IBD, Periodontitis
3. OMEGA-3 AND THE CARDIOVASCULAR SYSTEM - Blood pressure, Sudden death. Plasma lipids, Platelet aggregation, Arteriosclerosis, Arrhythmias, Atrial fibrillation
4. OMEGA-3 IN GESTATION, BREASTFEEDING AND INFANCY - Prevention of preterm birth, Pre-eclampsia, Premature infants, etc
5. OMEGA-3 IN GYNAECOLOGY
6. OMEGA-3 AND BEHAVIOURAL AND MENTAL DISORDERS - ADHD, Depression, Autism, Bipolar disorder, Borderline personality, Substance abuse, Psychotic disorders
7. OMEGA-3 AND CANCER
8. OMEGA-3 IN ADULT COGNITION
9. OMEGA-3 AND HEARING LOSS
10. OMEGA-3 AND VISION, etc
- Organic Meats have 50% more Omega-3 - meta-analysis Feb 2016 NYT
switching to organic meats only adds about 50 mg of Omega-3 - which is not very much
And Omega-6 was slightly lower in organic meats
- Cooking oils compared
InformationIsBeautiful.net March 2016
Here is a tiny portion of their analysis
- The role for dietary omega-3 fatty acids supplementation in older adults Oct 2014
Download the PDF from VitaminDWiki.
- Evidence-based nutritional advice for patients affected by age-related macular degeneration Feb 2014, free text online
- Role of omega-3 Fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials May 2014, free text online
- U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008 April 2014, free text online
- Helping women to good health: breast cancer, omega-3/omega-6 lipids, and related lifestyle factors March 2014, free text online
- ω-3 PUFAs in the Prevention and Cure of Inflammatory, Degenerative, and Neoplastic Diseases. Biomed Res Int. free full text online
- Statins appear to interfere with Omega-3 Jan 2013
- Cochraine review found that PUFA reduced MS relapses Dec 2012
- Impact of ω-3 fatty acids in Parkinson's disease. PubMed Sept 2011
Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease:
systematic review and meta-analysis Oct 2012
- Omega-3 fatty acids, insulin resistance and type 2 diabetes Oct 2011 free text online
- Association between fish consumption, long chain omega 3 fatty acids, and risk of cerebrovascular disease: systematic review and meta-analysis free text online
- Fetal and neonatal levels of omega-3: effects on neurodevelopment, nutrition, and growth 2012 free text online
- Celiac disease, inflammation and oxidative damage: a nutrigenetic approach. April 2012
- Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. May 2011
- Omega-3 fatty acids modify human cortical visual processing--a double-blind, crossover study. 2011
- 10-year cognition in preterms after random assignment to fatty acid supplementation in infancy. Oct 2011
- Long-chain omega-3 polyunsaturated fatty acids may be beneficial for reducing obesity-a review.
Dec 2010 PDF is attached at bottom of this page - it has the following graph of fat loss vs type of fat
- Dietary interventions for multiple sclerosis. Cochrane Dec 2012
Review of many RCT - Omega-3 reduced MS relapases by 18%, but was not statistically significant
- Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study Sept 2014
1080 mg eicosapentaenoic acid+docosahexaenoic acid) was associated with a 33.6% reduction in seizure frequency
2000 mg was similar to placebo - no reduction
PubMed Omega-3 Cardio
- Omega-3 polyunsaturated fatty acids and cardiac rhythm: an introduction. 2012 full text online
- Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling? 2012 free text online
- Omega-3 for patients with cardiovascular disease Nov 2012 free text online
- Omega-3 polyunsaturated fatty acids and cardiac rhythm: an introduction. Dec 2012 full text online
After almost 20 years, still no consensus
- Omega-3 index and cardiovascular health Feb 2014 free text online
- Omega-3 Fatty acids: anti-arrhythmic, pro-arrhythmic, or both? 2012
- Effect of omega-3 polyunsaturated fatty acids and vitamin D on cardiovascular diseases Feb 2014,
Download the PDF from VitaminDWiki__
PubMed Omega-3 Brain
- Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection. PubMed June 2011
- A nutrient combination that can affect synapse formation April 2014, free text online
- The older people, omega-3, and cognitive health (EPOCH) trial design and methodology:
a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids
on cognitive ageing and wellbeing in cognitively healthy older adults. Oct 2011
PubMed Omega-3 Cancer
- Omega-3 aids chemotherapy (by reducing inflammation) Jan 2013
Omega-3 reduce the risk only in patients not taking a statin
- Relationship of dietary intake of omega-3 and omega-6 Fatty acids with risk of prostate cancer development Dec 2012 full text online
a meta-analysis of prospective studies and reviewthe of literature.High intake of ALA may reduce risk of prostate cancer, while intake of long-chain omega-3 fatty acids does not have a significant effect.
- Omega-3 Fats Help Overcome Multi-Drug Resistant CancerNov 2013
Nothing about Vitamin D, but interesting anyway - mainly colon cancer, but it might apply to others as well.
- INTERVENTION Clinical trials with Omega-3 219 Added Jan 2014 thru Sept 2016
Bacterial and Fungal Diseases, Behaviors and Mental Disorders , Blood and Lymph Conditions
Cancers and Other Neoplasms , Digestive System Diseases, Diseases and Abnormalities at or before Birth
Ear, Nose, and Throat Diseases , Eye Diseases, Gland and Hormone Related Diseases
Heart and Blood Diseases, Immune System Diseases, Mouth and Tooth Diseases
Muscle, Bone, and Cartilage Diseases, Nervous System Diseases, Nutritional and Metabolic Diseases
Occupational Diseases, Parasitic Diseases, Respiratory Tract (Lung and Bronchial) Diseases
Skin and Connective Tissue Diseases, Substance Related Disorders , Symptoms and General Pathology
Urinary Tract, Sexual Organs, and Pregnancy Conditions; Viral Diseases; Wounds and Injuries
- Supplementing different ratios of short- and medium-chain fatty acids to long-chain fatty acids in dairy cows: Changes of milk fat production and milk fatty acids composition
Journal of Dairy Science, Feb 2013
The milk fat percentage and total SMCFA concentration in milk fat tended to increase linearly and the proportion of milk total solids increased linearly with increasing ratios of SMCFA to LCFA in the supplements, whereas milk fat yield was not changed.
Note:By US definitions Grass fed beed can be grain finished in a feedlot since the definitions are not regulations nor are they checked.
Also: the defintions allow feeding grain for about half of the year - when the grass is not growing
Fatty Acid Analysis of Grass-fed and Grain-fed Beef Tallow Masterjohn Jan 2014
Total PUFA Grain: 3.45% Grass: 1.9%
Now I know why the recent Meta-analysis of Omega-3 did not find any reduction in heart deaths - 2018
Previous version of the Cochrane analysis had excluded all trials with fewer than 50 deaths
This review looked at 2100 studies, and excluded 90% of them
This review did not mention if they had continued that outrageous exclusion.
details in Orthomolecular Nutrtion
I had wondered how the Cochrane Review could possibly have not found a benefit.
The reading of the paper did not indicate the reason. But now I have found out why.
I wonder how many other Cochrane reviews are similarly biased by excluding studies which find a benefit
Henry Lahore, founder of VitaminDWiki Aug 2018
- "Many people now consume 80 grams of PUFAs a day, which amounts to 720 calories and one-third of their caloric intake"
- "PUFAs became so popular that they now make up 63% of the American diet, form the basis of USDA food recommendations and are found in 600,000 processed foods sold in the U.S. today."
- " … the rats on the cottonseed oil grow to sixty percent of normal size and lived 555 days on average; they're, weak, fragile, sickly little rats. The rats on the butterfat they are healthy; they grow to normal size and they live 1020 days so they grow to almost twice the size of the cottonseed oil-fed rats, live twice as long and are infinitely more healthy."
Are We Finally Reaching Consensus About Fish Oil ? Life Extension Magazine editorial Aug 2020
Download the PDF from VitaminDWiki
"On February 26, 1987, the FDA conducted an armed raid against Life Extension®
The FDA seized our fish oil and brochures describing fish oil’s potential to reduce cardiovascular risk.
We fought a multi-year legal battle that resulted in the government dismissing all charges against Life Extension®, marking the first time in the FDA’s 88-year history that it has been forced to give up on a criminal prosecution"
Overview: Omega-3 many benefits include helping vitamin D
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