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Children with COVID 4X more likely to have poor Vitamin D Receptors (Note: COVID deactivates VDR) – April 2023

Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19

Pediatr Res. 2023 Apr;93(5):1383-1390. doi: 10.1038/s41390-022-02275-6
Nancy M S Zeidan 1, Hanan M Abd El Lateef 2, Dalia M Selim 2, Suzan A Razek 2, Ghada A B Abd-Elrehim 3, Mohamed Nashat 4, Noha ElGyar 5, Nevin M Waked 6, Attia A Soliman 7, Ahmed A Elhewala 7, Mohamed M M Shehab 7, Ahmed A A Ibraheem 7, Hassan Shehata 7, Yousif M Yousif 7, Nagwa E Akeel 7, Mustafa I A Hashem 7, Amani A Ahmed 7, Ahmed A Emam 8, Mohamed M Abdelmohsen 9, Mohamed F Ahmed 9, Ahmed S E Saleh 10, Heba H Eltrawy 11, Gehan H Shahin 12, Rehab M Nabil 13, Thoraya A Hosny 13, Mohamed R Abdelhamed 14, Mona R Afify 15, Mohanned T Alharbi 15, Mohammed K Nagshabandi 15, Muyassar K Tarabulsi 15, Sherif F Osman 16, Amal S M Abd-Elrazek 17, Manal M Rashad 18, Sonya A A El-Gaaly 19, Said A B Gad 20, Mohamed Y Mohamed 21, Khalil Abdelkhalek 1, Aly A Yousef 22

Background: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility.

Methods: One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21-29 ng/mL, deficient at <20 ng/mL.

Results: Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency.
Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96-4.9]; P = 0.002.
The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95-8.55]; P < 0.001).

Conclusions: Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents.
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VitaminDWiki - Vitamin D Receptor deactivated by some health problems - many studies

VitaminDWiki has 36 studies which are in both VDR and Virus categories

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators

Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3 Waist size
3 Ischemic Stroke
9X in women
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
?? Rickets - Vitamin D resistant

Attached files

ID Name Comment Uploaded Size Downloads
19522 COVID VDR Children.jpg admin 29 Apr, 2023 28.54 Kb 133
19521 VDR 4X if COVID_CompressPdf.pdf admin 29 Apr, 2023 304.14 Kb 62