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T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021

Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies

Journal of Diabetes and Metabolic Disorders 2021, 20 (1): 845-867
Surendar Aravindhan, Mohammed Fadhil Mohammed Almasoody, Nihad Abdallah Selman, Alekhina Natalia Andreevna, Sahithya Ravali, Payam Mohammadi, Mohammad Masoud Eslami, Bahman Razi, Saeed Aslani, Danyal Imani


Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 530 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 43;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies

Items in both categories Vitamin D Receptor and Diabetes are listed here:

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

Observation: A person with Diabetes should consider:

  1. Increasing intake of vitamin D to get more vitamin D in the blood - especially a gut-friendly form
  2. Taking one or more of the Receptor activators (above) to get more vitamin D from the blood to the cells

 Download the PDF from VitaminDWiki



Background: Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. Here we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms and susceptibility to T2D.

Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T2D published up to August 2020 were identified by comprehensive systematic database search in web of science, Scopus, and Medline. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure strength of association. The methodological quality of each study was assessed according to the Newcastle-Ottawa Scale. Subgroup and meta-regression analysis were also performed.

Results: A total of 47 case-control studies were included in this meta-analysis. The overall population results revealed a significant association between FokI, and BsmI (heterozygote model) polymorphisms and T2D in the overall analysis. However, no association was found with the TaqI and ApaI polymorphisms. Moreover, the pooled results of subgroup analysis by ethnicity suggested significant association between FokI, TaqI , and BsmI polymorphisms and T2D in some subgroups. Meta-regression analyses indicated that none of the publication year, ethnicity, and genotyping method were the source of heterogenicity in all four polymorphisms.

Conclusions: This meta-analysis suggested a significant association between VDR gene FokI , and BsmI (heterozygote model) polymorphisms and T2D susceptibility in overall population and ethnic-specific analysis.

Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-020-00704-z.

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Created by admin. Last Modification: Wednesday July 5, 2023 14:55:31 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
15886 VDR Dominant Fokl Diabetes.jpg admin 08 Jul, 2021 16:03 43.37 Kb 261
15885 VDR Allelic Fokl Diabetes.jpg admin 08 Jul, 2021 16:03 44.90 Kb 267
15884 VDR Fokl Diabetes.jpg admin 08 Jul, 2021 16:02 41.39 Kb 282
15883 VDR Diabetes_compressed.pdf PDF 2021 admin 08 Jul, 2021 16:02 709.95 Kb 267