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Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019

Associations between twelve common gene polymorphisms and susceptibility to hepatocellular carcinoma: evidence from a meta-analysis.

World J Surg Oncol. 2019 Dec 12;17(1):216. doi: 10.1186/s12957-019-1748-8.
Quan Y1, Yang J1, Qin T1, Hu Y2.

VitaminDWiki

A poor Vitamin D Receptor is associated with many cancers (oral cancer in this case) – Jan 2019 has the follwing:

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:


 Download the PDF from Sci-Hub via VitaminDWiki

BACKGROUND:
Associations between polymorphisms in vitamin D receptor (VDR)/vascular endothelial growth factor (VEGF)/interleukin-18 (IL-18)/mannose-binding lectin (MBL) and susceptibility to hepatocellular carcinoma (HCC) were already explored by many studies, yet the results of these studies were inconsistent. The aim of this meta-analysis was to better clarify associations between polymorphisms in VDR/VEGF/IL-18/MBL and HCC by combing the results of all relevant studies.

METHODS:
Eligible publications were searched from PubMed, Embase, WOS, and CNKI. We used Review Manager to combine the results of individual studies.

RESULTS:
Thirty studies were included in this study. Combined results revealed that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms were all significantly associated with HCC in the overall pooled population. We also obtained similar significant associations for VDR rs7975232, VDR rs2228570, IL-18 rs1946518, and MBL rs7096206 polymorphisms in Asians.

CONCLUSIONS:
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.


Created by admin. Last Modification: Saturday December 14, 2019 15:03:38 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
13149 Liver cancer gene meta.pdf PDF 2019 admin 14 Dec, 2019 14:46 732.00 Kb 82
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