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Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020

Transcriptome Analysis of Early Pregnancy Vitamin D Status and Spontaneous Preterm Birth

PLoS One, 15 (1), e0227193 2020 Jan 29 eCollection 2020, DOI: 10.1371/journal.pone.0227193
Aishwarya P Yadama 1, Hooman Mirzakhani 1, Thomas F McElrath 2, Augusto A Litonjua 3, Scott T Weiss 1


Items in both categories Pregnancy and Vitamin D Receptor:

Vitamin D Receptor is associated in over 58 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Reductions in Vitamin D is.gd/VitDReductions
click on chart for details

 Download the PDF from VitaminDWiki

Vitamin D Receptor is directly or indirectly connected to Spontaneous Preterm Birth genes



Background: We conducted a literature review on the studies that investigated the relationship of preterm birth, including spontaneous preterm birth (sPTB), with vitamin D status. Overall, these studies demonstrated that the incidence of sPTB was associated with maternal vitamin D insufficiency in early pregnancy. However, the potential mechanisms and biological pathways are unknown.

Objectives: To investigate early pregnancy gene expression signatures associated with both vitamin D insufficiency and sPTB. We further constructed a network of these gene signatures and identified the common biological pathways involved.

Study design: We conducted peripheral blood transcriptome profiling at 10-18 weeks of gestation in a nested case-control cohort of 24 pregnant women who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In this cohort, 8 women had spontaneous preterm delivery (21-32 weeks of gestation) and 17 women had vitamin D insufficiency (25-hydroxyvitamin D < 30 ng/mL). We separately identified vitamin D-associated and sPTB gene signatures at 10 to 18 weeks and replicated the overlapping signatures in the mid-pregnancy peripheral blood of an independent cohort with sPTB cases.

Result: At 10-18 weeks of gestation, 146 differentially expressed genes (25 upregulated) were associated with both vitamin D insufficiency and sPTB in the discovery cohort (FDR < 0.05). Of these genes, 43 (25 upregulated) were replicated in the independent cohort of sPTB cases and controls with normal pregnancies (P < 0.05). Functional enrichment and network analyses of the replicated gene signatures suggested several highly connected nodes related to inflammatory and immune responses.

Conclusions: Our gene expression study and network analyses suggest that the dysregulation of immune response pathways due to early pregnancy vitamin D insufficiency may contribute to the pathobiology of sPTB.

Created by admin. Last Modification: Thursday January 30, 2020 15:57:39 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
13423 PTB table.jpg admin 30 Jan, 2020 15:17 531.33 Kb 179
13422 PTB VDR.jpg admin 30 Jan, 2020 15:16 119.84 Kb 164
13421 Transcriptome PTB.pdf PDF 2020 admin 30 Jan, 2020 15:16 1.45 Mb 130
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