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Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020

Vitamin D Receptor Genetic Polymorphisms and the Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis

Steroids, 108615 2020 Feb 22, DOI: 10.1016/j.steroids.2020.108615
Asadollah Mohammadi 1, Asaad Azarnezhad 1, Hashem Khanbabaei 2, Esmael Izadpanah 3, Rasoul Abdollahzadeh 4, George E Barreto 5, Amirhossein Sahebkar 6


The articles in both of the categories MS and Vitamin D Receptor are:

UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 12 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

 Download the PDF from Sci-Hub via VitaminDWiki

There are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-control studies evaluating the association between VDR gene polymorphisms and MS risk in Iran. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Subgroup analyze was performed to detect potential sources of heterogeneity. A total of 1206 cases and 1402 controls in nine case-control studies were included. ApaI was the only variant which showed statistically significant relation in

  • allelic (OR=0.54 (95% CI: 0.37-0.79); P=0.00),
  • homozygote (OR=3.48 (95% CI: 1.7-6.9); P=0.00),
  • dominant (OR=0.56 (95% CI: 0.3-0.79); P=0.01), and
  • recessive (OR=0.35 (95% CI: 0.18-0.66); P=0.00) models.

The TaqI polymorphism showed a significant negative association with MS only in the homozygote model

  • (OR= 0.28 (95% CI: 0.08-0.9); P=0.04).

The BsmI polymorphism also showed significant relation in

  • allelic (OR= 0.69 (95% CI: 0.51-0.94); P=0.01),
  • homozygote (OR= 0.46 (95% CI: 0.25-0.86); P=0.01), and
  • recessive OR= 0.56 (95% CI: 0.39-0.8); P=0.00) models after performing sensitivity analysis.

FokI polymorphism showed no significant association with MS risk. ApaI and TaqI TT genotype were found contributing to MS susceptibility and BsmI and FokI showed no relation with MS susceptibility in the Iranian population.

Similar conclusion (1.8X) in a paper published Feb 2021__

__Association between polymorphisms in the vitamin D receptor and susceptibility to multiple sclerosis
Pharmacogenet Genomics. 2021 Feb 1;31(2):40-47. doi: 10.1097/FPC.0000000000000420.
Bárbara Cancela Díez 1, Cristina Pérez-Ramírez 2, María Del Mar Maldonado-Montoro 3, María Isabel Carrasco-Campos 1, Almudena Sánchez Martín 1, Laura Elena Pineda Lancheros 1, Fernando Martínez-Martínez 4, Miguel Ángel Calleja-Hernández 2, María Carmen Ramírez-Tortosa 5, Alberto Jiménez-Morales 1

Objectives: Multiple sclerosis (MS) is a neurodegenerative chronic inflammatory. Mutations in the vitamin D receptor (VDR) gene can substantially affect serum vitamin D levels or alter its functionality, and can consequently increase susceptibility to developing MS. The objective of this study was to evaluate the association between polymorphisms in the VDR gene and risk of MS in a (Spanish) Caucasian population.

Patients and methods: We conducted a retrospective case-control study comprising 209 patients with relapsing-remitting multiple sclerosis (RRMS) and 836 controls of Caucasian origin from southern Spain. The ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs2228570), and TaqI (rs731236) gene polymorphisms were determined by allelic discrimination real-time PCR using TaqMan probes.

Results: The recessive logical regression model, adjusted for age and sex, revealed that the TT genotype for VDR FokI (rs2228570) polymorphism was associated with higher risk of MS (P = 0.0150; OR = 1.82; 95% CI = 1.12-2.94; TT vs. CT + CC). No association between the other polymorphisms and development of MS was found in any of the models analyzed. The haplotype analysis, adjusted for age, smoking, and sex, did not find any statistically significant association between the haplotypes analyzed and risk of MS.

Conclusions: The VDR FokI (rs2228570) polymorphism was significantly associated with developing MS. We found no influence of the ApaI (rs7975232), BsmI (rs1544410), Cdx2 (rs11568820), FokI (rs2228570), and TaqI (rs731236) gene polymorphisms on the risk of developing MS in our patients.

Created by admin. Last Modification: Friday January 1, 2021 10:01:38 GMT-0000 by admin. (Version 3)

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13538 MS VDR meta Sci-Hub.pdf admin 26 Feb, 2020 1.16 Mb 518