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Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020

Vitamin D Receptor Genetic Polymorphisms and the Risk of Multiple Sclerosis: A Systematic Review and Meta-Analysis

Steroids, 108615 2020 Feb 22, DOI: 10.1016/j.steroids.2020.108615
Asadollah Mohammadi 1, Asaad Azarnezhad 1, Hashem Khanbabaei 2, Esmael Izadpanah 3, Rasoul Abdollahzadeh 4, George E Barreto 5, Amirhossein Sahebkar 6


The articles in both of the categories MS and Vitamin D Receptor are:

UV and Sunshine reduces MS risk

Other things also help

High Dose Vitamin D and cofactors

Number of MS studies which are also in other categories

  • 20 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells
  • 11 studies in Vitamin D Receptor - gene which restricts D from getting to the cells
  • 5 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells
  • 19 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS
  • 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS

 Download the PDF from Sci-Hub via VitaminDWiki

There are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-control studies evaluating the association between VDR gene polymorphisms and MS risk in Iran. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Subgroup analyze was performed to detect potential sources of heterogeneity. A total of 1206 cases and 1402 controls in nine case-control studies were included. ApaI was the only variant which showed statistically significant relation in

  • allelic (OR=0.54 (95% CI: 0.37-0.79); P=0.00),
  • homozygote (OR=3.48 (95% CI: 1.7-6.9); P=0.00),
  • dominant (OR=0.56 (95% CI: 0.3-0.79); P=0.01), and
  • recessive (OR=0.35 (95% CI: 0.18-0.66); P=0.00) models.

The TaqI polymorphism showed a significant negative association with MS only in the homozygote model

  • (OR= 0.28 (95% CI: 0.08-0.9); P=0.04).

The BsmI polymorphism also showed significant relation in

  • allelic (OR= 0.69 (95% CI: 0.51-0.94); P=0.01),
  • homozygote (OR= 0.46 (95% CI: 0.25-0.86); P=0.01), and
  • recessive OR= 0.56 (95% CI: 0.39-0.8); P=0.00) models after performing sensitivity analysis.

FokI polymorphism showed no significant association with MS risk. ApaI and TaqI TT genotype were found contributing to MS susceptibility and BsmI and FokI showed no relation with MS susceptibility in the Iranian population.

Created by admin. Last Modification: Wednesday February 26, 2020 12:01:45 GMT-0000 by admin. (Version 2)

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13538 MS VDR meta Sci-Hub.pdf PDF 2020 admin 26 Feb, 2020 12:00 1.16 Mb 107
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