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Long-COVID is now the biggest COVID concern - many studies

Table of contents


Long-COVID symptoms- Sept 2022

Harvard Magazine
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A Long-COVID protocal by David Archibald - Dec 1, 2022

PDF online
mentions varsious supplemnts, but does not descibe how much of each
Magnesium
Glutathione — the most powerful endogenous antioxident, so the body doesn’t have to expend energy to make it.
Melatonin — antioxidant
Vitamin D — antioxidant, adults could dose at 10,000 IU per day. Inflammation chews through the body’s vitamin D stores.
Vitamin C — antioxidant
Quercetin — zinc ionophore, vitamin D receptor activator, antiviral
CoQ10 — antioxidant
Zinc — antiviral
N-acetyl cysteine — precursor to glutathione
Selenium — involved in glutathione synthesis
Boron — antiviral
Vitamin B 6 — immune system maintenance
Vitamin B 12 — immune system maintenance
Vitamin B 9 — immune system maintenance
D-ribose — helps produce ATP (adenosine triphosphate)
Antihistamines such famotadine or low dose naltrexone will reduce inflammation.

Does not appear to have any data


2nd COVID infection increased by 3X chance of going to hospital in next 6 months (US veterans) - Nov 2022

Acute and postacute sequelae associated with SARS-CoV-2 reinfection  PDF Veterans Administration
See also COVID deaths: 3rd as many if any dose, half as many if 50K IU Vitamin D – Campbell transcript Nov 2022


Long-COVID treatment trial starting Nov 2022

Trial Site News

  • Group 1 will receive 30g of Intravenous Vitamin C twice weekly for 6 weeks, administered by a registered nurse
  • Group 2 will receive all the following oral supplements as capsules [Kyolic aged garlic extract (1.2 g) + Fish oil (2g) + Curcumin (500mg) + N-acetylcysteine (600mg) + Vitamin D (5000 IU) + Vitamin C (1g) + Zinc (15mg)] daily for 6 weeks, administered by the principal investigator; adherence will be monitored by return of unused supplements at the end of the 6-week period.

* Group 3 will continue to receive the nutritional supplement consisting of 35g pineapple powder + 2x3g ginger infused oil per day to be consumed with food at mealtimes as convenient for 6 weeks; adherence monitored by diary.
Click here for details


I’m a physician battling long COVID. I can assure you it’s real - Oct 28, 2022

MD Edge

  • "One in 5. It almost seems unimaginable that this is the real number of people who are struggling with long COVID,..."
  • "In my case, as an All-American Masters miler with several marathons under my belt, running 5 miles is a walk in the park. But now, I pay for those 5 miles for the rest of the day on the couch or with palpitations, dizziness, and fatigue the following day"
  • ""This has made me realize that we cannot wait on an evidence-based approach – which can take decades to develop – while people are suffering."

Increased use of medical services after test postive for COVID (in Ontario) - Oct 2022

ICES Study: Long COVID Leads to Considerable Health System Utilization in Ontario, Canada
Compared services utilized by those infected (268,521) to those not infected and had similar cormorbidities, etc.
Jan 2020 to April 2021
Increased usage started about 2 months after COVID test-positive
CMAJ 2022 October 17;194:E1368-76. doi: 10.1503/cmaj.220728  PDF
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Long-COVID fought in some individuals by Lumbrokinase, Heparin, or Natto Serra - 2022

All PDFs by Eugene Heyden (RN)
Lumbrokinase !hs! Heparin   Natto-Serra


Long COVID may set you back a decade in exercise gains - Oct 13, 2022

Washington Post     PDF

Personal experience - recovering from about 20 years of lost respiratory capacity - founder of VitaminDWiki

2020: I routinely biked up a 1-mile hill 3 times with 36 lbs attached to my bike
   My last vaccination was about 60 years ago
At no time did I have symptoms of COVID infection (Vitamin D level currently 180 ng) - perhaps had asymptomatic COVID
Note: Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021
2021: I could not get up the 1-mile hill once with only 12 lbs attached to my bike
Strongly felt it was due to reduced inhalation capacity
Had a lung function test and was using Albuterol for about a month
My doctor wanted to prescribe an Albuterol alternative for the rest of my life. I refused.
I purchased and am using a lung exercise device__
Sept 2022: Recovering - after 2 weeks I am now able to bike up the hill twice with 12 lbs
Have ceased using Albuterol
Looking forward to using more weight on my bike and/or going up the hill more times

Notes

  • Might not have been Long-COVID, but instead a long-term adverse reaction to Sudafed (Pseudoephedrine)
  • I have been using (Inhaled Vitamin D) before intense exercise since about 2017

47% of Covid Patients had NOT Fully Recovered 6 months later - Oct 2022

Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland study
Nature Communications volume 13, Article number: 5663 (2022) https://doi.org/10.1038/s41467-022-33415-5
Claire E. Hastie, David J. Lowe, Andrew McAuley, Andrew J. Winter, Nicholas L. Mills, Corri Black, Janet T. Scott, Catherine A. O’Donnell, David N. Blane, Susan Browne, Tracy R. Ibbotson & Jill P. Pell

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Many interesting tables in PDF

With increasing numbers infected by SARS-CoV-2, understanding long-COVID is essential to inform health and social care support. A Scottish population cohort of 33,281 laboratory-confirmed SARS-CoV-2 infections and 62,957 never-infected individuals were followed-up via 6, 12 and 18-month questionnaires and linkage to hospitalization and death records. Of the 31,486 symptomatic infections,1,856 (6%) had not recovered and 13,350 (42%) only partially. No recovery was associated with hospitalized infection, age, female sex, deprivation, respiratory disease, depression and multimorbidity. Previous symptomatic infection was associated with poorer quality of life, impairment across all daily activities and 24 persistent symptoms including

  • breathlessness (OR 3.43, 95% CI 3.29
  • chest pain (OR 2.09, 95% CI 1.96–2.23), and
  • confusion (OR 2.92, 95% CI 2.78–3.07).

Asymptomatic infection was not associated with adverse outcomes.
Vaccination was associated with a reduced risk of seven symptoms.
Here we describe the nature of long-COVID and the factors associated with it.
 Download the PDF from VitaminDWiki


Type 1 Diabetes 2.9 x more likely within 30 days of COVID infection - Oct 2022

SARS-CoV-2 & the Incidence of Diabetes 1 in Children Trial Site News
"cohort of 1,849,411 individuals aged younger than 35 years without diabetes, who were followed from March 1, 2020, to Nov. 22, 2021."
FREE PDF


Strokes, heart attacks, sudden deaths: Does America understand the long-term risks of catching COVID? - Oct 2022

fortune Magazine

  • "A large international study involving 136 research institutions in 32 countries has documented an increased incidence of ischemic strokes in young patients compared to pre-pandemic levels. More than a third were under the age of 55, and many lacked typical risk factors such as smoking, diabetes, and high blood pressure."
  • "In a study that included patients from the initial wave of the pandemic, scientists from the University of Florida found that survivors of severe COVID-19 had two-and-a-half times the risk of dying in the year following illness compared to people who were never infected"

Wide spectrum of types, severity, and duration of Long-COVID problems - Oct 2022

The Atlantic Long-COVID problems include
organ damage,   profound physical debilitation,   poor mental health,   acute respiratory distress syndrome,   failing hearts,   collapsed lungs,   failed kidneys,   brain hemorrhages,   limbs cut off from blood flow,   heart disease,   stroke,   blood clot,   diabetes,   asthma,   and kidney failure,   shortness of breath,   chest pain,   protracted cough,   lingering loss of sense of smell,   severe fatigue,   “internal tremors,   ” gastrointestinal problems,   palpitations,   dizziness,   tiny clots to block tiny blood vessels all over the body,   Psychosocial strain and suffering,   severe depression,   crushing fatigue,   withering brain fog,   reversible cardiovascular deconditioning (can lead to a racing heart rate or faintness when standing)


The consensus of 3 long-COVID studies - SARS-CoV-2 in tissue, Epstein virus makes it worse - Oct 2022

New Ideas Emerge Concerning How to Treat Long COVID Trial Site News
Consensus has emerged on three points:

  1. In Long COVID, reservoirs of replicating SARS-CoV-2 virus remain in tissue beyond when it detected in blood or mucus.
  2. IIn Long COVID, whole spike (in addition to S1) is often detected in blood samples, and the level does not seem to abate over time.
  3. Activation of Epstein-Barre Virus (EBV) latent infection often exacerbates Long COVID.

4th indication that SARS-CoV-2 virus remains TrIals Site News Oct 7 , https://doi.org/10.1093/cid/ciac722


Long-COVID is US: 16 million, of which 4 million are unable to work - Oct 2022

Desperate long COVID patients turn to unproven alternative therapies MD Edge]
Probiotics and Omega-3 were mentioned as helpful
No discussion of D-Ribose, VDR activators, or vitamin D - see below


42% increased chance of neuro problems with Long-COVID - Dr. Campbell Video Sept 26, 2022

YouTube
Long-term neurologic outcomes of COVID-19 (US Veterans) - Nature Medicine Sept 22, 2022 hs~PDF


Long COVID Has Forced a Reckoning for One of Medicine’s Most Neglected Diseases (CFS) - Sept 2022

The Atlantic

  • "ME/CFS involves a panoply of debilitating symptoms that affect many organ systems and that get worse with exertion. The Institute of Medicine estimates that it affects 836,000 to 2.5 million people in the U.S. alone, but is so misunderstood and stigmatized that about 90 percent of people who have it have never been diagnosed. "
  • "Many cases of long COVID are effectively ME/CFS by another name. The exact number is hard to define, but past studies have shown that 5 to 27 percent of people infected by various pathogens, including Epstein-Barr virus and the original SARS, develop ME/CFS. Even if that proportion is 10 times lower for SARS-CoV-2, the number of Americans with ME/CFS would still have doubled in the past three years."
  • "American ME/CFS patients may outnumber the population of 15 individual states, but ME/CFS specialists couldn’t fill a Major League Baseball roster." (26 doctors)
  • "The hallmark symptom of ME/CFS—post-exertional malaise, or PEM—means even light physical or mental exertion can trigger major crashes that exacerbate every other symptom. Doctors who are unfamiliar with PEM, including many now running long-COVID clinics, can unwittingly hurt their patients by encouraging them to exercise."


See in VitaminDWiki
Overview Fibromyalgia or Chronic Fatigue and vitamin D
  large doses of vitamin D reduced CFS/Fibromyalgia in > 10 studies
((Chronic Fatigue Syndrome and long-haul COVID-19)


2 X higher rate of Long-COVID in the US (online survey) than in the UK - Sept 2022

US, Mass disabling event - Dr. Campbell video
US data comes from a long online survey (which takes 20 minutes to complete)
UK data - apparently not an online survey
More in Women than men in both US and UK


One of Long COVID’s Worst Symptoms Is Also Its Most Misunderstood (brain fog) - Sept 12, 2022

The Atlantic

  • "It’s also among the most misunderstood. It wasn’t even included in the list of possible COVID symptoms when the coronavirus pandemic first began. But 20 to 30 percent of patients report brain fog three months after their initial infection, as do 65 to 85 percent of the long-haulers who stay sick for much longer. "
  • "At its core, Hellmuth said, it is almost always a disorder of “executive function”—the set of mental abilities that includes focusing attention, holding information in mind, and blocking out distractions."
  • "That specific constellation of problems also befalls many people living with HIV, epileptics after seizures, cancer patients experiencing so-called chemo brain, and people with several complex chronic illnesses such as fibromyalgia. It’s part of the diagnostic criteria for myalgic encephalomyelitis, also known as chronic fatigue syndrome, or ME/CFS—a condition that Davis and many other long-haulers now have." (many hyperlinks at the website)

See also https://en.wikipedia.org/wiki/Clouding_of_consciousness


Perhaps brain fog could be treated by brain palsticity (opinion of the founder of VitaminDWiki)

If I had brain fog, I would use my computer program that has greatly improved brain plasticity for me for over a decade.
About 1/3 of BrainHQ exercises can be used for free. https://www.brainhq.com/
I would use it for at least 30 minutes a day and would anticipate noticeably reduced fog in less than a week.
   Google Search of "brain fog" "brain plasticity" gets 93,000 results Oct 2022

See related in VitaminDWiki


Person having long-COVID for 400 days was operated on - had virus in his appendix and skin - Sept 2022

Dr. Been YouTube Video
Nasal and throat tests were negative, Virus set up camp elsewhere in the body
What % of people with long-COVID actually still have COVID?


Long-COVID is a $3.5 trillion dollar problem that we know very little about - Sept 2022

'No man's land': Long COVID knocks young workers out of the job market ABC News Sept 5
"calculations factor in lost earnings, medical care and lower quality of life."


Increased health problems due to Long-COVID - March 2020 - Nov 2021 (published Sept 2022)

Note: This is pre-Omicron
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 Download PNAS PDF
Discusses many possible reasons. including microclotting


US VA handbook of Long-COVID 33 pages - Aug 2022

 Download PNAS PDF


For Some Patients, Long Covid Symptoms Mask Something Else - Aug 2022

The condition may be common, but issues like fever, shortness of breath, and fatigue can also be signs of other illnesses. Wired Magazine]

  • "... long Covid can be easily confused with countless other conditions, including cardiovascular diseases such as hypertension and diabetes, autoimmune diseases like lupus and multiple sclerosis, and cancer."
  • "A July paper in Nature that analyzed the medical records of over 2 million patients in the UK found that, while 5.4 percent of those with a previous Covid infection had at least one long Covid symptom recorded in their charts, 4.5 percent without evidence of infection__ also had at least one symptom."

15 other long-haul diseases: EBV, Polio, mono, 1918 influenza, Zika, Dengue - Aug 2022

It’s Not Just Long COVID The Atlantic

  • Unexplained post-acute infection syndromes - May 2022  PDF

Image   Image


LONG-COVID incidence: was I in 10, now 1 in 20 if an asymptomatic infection - June 2022

Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021
Half as much Long-Haul with Omicron - June 2022
COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022


LONG-COVID can last for many months - preventing some people from working - June 2022

Mass disabling events: Polio, WWII, HIV, and COVID Long-Haul - June 2022
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) which contains
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COVID protects itself by changing the activation of > 100 genes - April 2021

COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
COVID-19 severity associated with 3 vitamin D genes – Oct 2021


COVID fails to revert the gene activation to normal when it is conquered (Epstein)

This is a good environment for the Epstein Virus to re-emerage
VitaminDWiki pages with "EPSTEIN in title
This list is automatically updated

Items found: 14

COVID, for example, protects itself by decreasing the activation of the Vitamin D Receptor

30 studies in both categories Virus and Vitamin D Receptor

This list is automatically updated


Vitamin D and Vitamin D receptor activators should treat Long-COVID


Long COVID’s grip will likely tighten as infections continue - Aug 2022

MDEdge

  • "The HHS said in its Aug. 4 report that long COVID could keep 1 million people a day out of work, with a loss of $50 billion in annual pay."
  • "A study from the University of Norway published in Open Forum Infectious Diseases found 53% of people tested had at least one symptom of thinking problems 13 months after infection with COVID-19."
  • "Dr. Vos’s most recent study, which is being peer-reviewed and revised, found that most people with long COVID have symptoms similar to those seen in other autoimmune diseases."

LONG-COVID has similar symptoms as Chronic Fatigue Syndrome

Chronic Fatigue Syndrome and long-haul COVID-19
Overview Fibromyalgia or Chronic Fatigue and vitamin D


Many Chronic Fatigue symptoms are treated by D-Ribose

D-Ribose is a natural sugar of the body that help the mitochondria in the cells produce ATP – needed for energy
The founder of VitaminDWiki has used D-Ribose for 20 years to replace the energy lost after intense exercise
He currently buys D-Ribose in bulk on Amazon
D-Ribose successfully treated Chronic Fatigue Syndrome in a clinical trial in 2010  PDF
Other supplements, such as Vitamin D, Probiotics, and Omega-3 also reduce LONG-HAUL symptoms


Many reports on the web of D-Ribose treating LONG-COVID

  • Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 ‘long-haulers’? - March 2021 10.1016/j.cdtm.2020.11.002 FREE PDF
  • This Sugar Cured One Woman’s Long Covid Symptoms Dec 2021

The Founder of VitaminDWiki suspects that a heaping teaspoon of D-Ribose taken 4 times daily should result in significant energy restoration in less than a week.
Note: Since D-Ribose only treats a symptom, it may have to be continued for many months


VitaminDWiki with LONG-HAUL or LONG-COVID in the title (52 as of Oct 2022)

Items found: 51
Title Modified
Long-COVID fatigue reduced by Vitamin C and l-Arginine in one month– RCT Nov 2022 24 Nov, 2022
Adrenal, Long-COVID and Vitamin D - several studies 31 Oct, 2022
Long Covid, Short Magnesium - Chambers April 2022 30 Oct, 2022
Fatigue and other long-haul problems appear to be associated with low Magnesium - Chambers Oct 2022 30 Oct, 2022
Long-COVID symptoms in 10 Percent of women 3 months after infection (22 countries) – Oct 2022 29 Oct, 2022
Long-COVID is now the biggest COVID concern - many studies 16 Oct, 2022
Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies 02 Oct, 2022
Anti-oxidants and Long-Covid (Mg, Glutamate, Butyrate, etc) – Sept 2022 02 Oct, 2022
Chronic Fatigue Syndrome and long-haul COVID-19 26 Sep, 2022
Over Two Million Americans Aren’t Working Due to Long-COVID - Aug 2022 27 Aug, 2022
Long-COVID: often had not been hospitalized - May 2022 25 Aug, 2022
COVID virus persists in most body tissues (Long-COVID) - 2022 23 Aug, 2022
Long COVID Persists in Almost All Tissues of The Body 23 Aug, 2022
Long-COVID in VitaminDWiki 16 Aug, 2022
LONG-COVID may be permanent in 1 in 200 of people infected – July 2022 06 Aug, 2022
LONG-COVID may be permanent in 1 in 200 of people infected – July 2022 06 Aug, 2022
Long-Haul more prevalent among seniors - June - 2022 26 Jun, 2022
Long-Haul can now be claimed a work disability in the UK – June 2022 24 Jun, 2022
Half as much Long-Haul with Omicron - June 2022 19 Jun, 2022
Half as much Long-Haul with Omicron - June 2022 19 Jun, 2022
COVID Spike persists in Long Haul - June 2022 18 Jun, 2022
COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022 17 Jun, 2022
COVID and Magnesium - hypothesis, clinical trials, Long-Haul - Oct 2021 10 Jun, 2022
Mass disabling events: Polio, WWII, HIV, and COVID Long-Haul - June 2022 06 Jun, 2022
1 in 5 Americans who got COVID had Long-Haul for a while - CDC May 2022 27 May, 2022
Long-Haul COVID after 3 months – only 5 percent had even 30 ng of Vitamin D – April 2022 04 May, 2022
Hypothesis: 2 long-haul COVIDs: had mild symptoms and had needed ICU - April 2022 15 Apr, 2022
COVID Long-Haul at 49 weeks: overactive immune system, type O blood - March 2022 07 Apr, 2022
Children have less severe COVID, but just as much long-haul as adults - April 2022 06 Apr, 2022
Dietary Recommendations for COVID Long-Haul – March 2022 20 Mar, 2022
Mild Long-Haul 4.2 X more likely if type O blood - preprint March 16, 2022 20 Mar, 2022
Long-Haul COVID is somewhat less of a problem if vaccinated – Nov 2021 18 Mar, 2022
COVID Long-Haul NYT - Feb 2022 19 Feb, 2022
COVID Long-Haul fought by probiotics - Jan 2022 29 Jan, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 26 Jan, 2022
Some COVID-19 infection become COVID Long-Haul - Nov 2020 15 Dec, 2021
Epstein-Barr virus appears to cause Long-Haul and Chronic fatiure Syndrome (Vitamin D might help) 11 Dec, 2021
Long-haul after breakthrough COVID – Nov 2021 11 Dec, 2021
Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 21 Sep, 2021
Your Brain on Covid-19 Long-Haul, Dr. Galland video and transcript - Aug 1, 2021 07 Aug, 2021
Long-haul COVID-19 blood tests at Mayo include vitamin D (but no results published) – July 2021 20 Jul, 2021
Most people with Long-Haul COVID-19 have low Vitamin D – July 2021 15 Jul, 2021
‘Long haul’ COVID rehab worse than cancer rehab, CDC – July 2021 13 Jul, 2021
Long-Haul COVID-19 occurred to 1 in 20 who had been asymptomatic (a study of 2 million with COVID-19) – June 2021 15 Jun, 2021
COVID-19 Long haul - excellent graph - systematic review May 26, 2021 26 May, 2021
COVID-19 vaccines look good in the short term, but probably not good for the long term 29 Apr, 2021
Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020 16 Apr, 2021
Probably fewer long-haul COVID-19 problems when rejuvenated immune system (Vitamin D, etc.)– Dec 2020 21 Feb, 2021
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021
Long-distance truck drivers more likely to get COVID-19 (perhaps UVA)- July 2020 12 Aug, 2020

Long-COVID – Emergent Pandemic – Dec 2021

Long COVID a New Derivative in the Chaos of SARS-CoV-2 Infection: The Emergent Pandemic?
J. Clin. Med. 2021, 10(24), 5799; https://doi.org/10.3390/jcm10245799

PDF Table of Contents
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Coronavirus disease 2019 (COVID-19) is a multisystem illness caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which can manifest with a multitude of symptoms in the setting of end-organ damage, though it is predominantly respiratory. However, various symptoms may remain after acute SARS-CoV-2 infection, and this condition is referred to as “Long COVID” (LC). Patients with LC may develop multi-organ symptom complex that remains 4–12 weeks after the acute phase of illness, with symptoms intermittently persisting over time. The main symptoms are fatigue, post-exertional malaise, cognitive dysfunction, and limitation of functional capacity. Pediatric patients developed the main symptoms of LC like those described in adults, although there may be variable presentations of LC in children. The underlying mechanisms of LC are not clearly known, although they may involve pathophysiological changes generated by virus persistence, immunological alterations secondary to virus–host interaction, tissue damage of inflammatory origin and hyperactivation of coagulation. Risk factors for developing LC would be female sex, more than five early symptoms, early dyspnea, previous psychiatric disorders, and alterations in immunological, inflammatory and coagulation parameters. There is currently no specific treatment for LC, but it could include pharmacological treatments to treat symptoms, supplements to restore nutritional, metabolic, and gut flora balance, and functional treatments for the most disabling symptoms. In summary, this study aims to show the scientific community the current knowledge of LC.
 Download the PDF from VitaminDWiki


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18121 D-0ribose CFS clinical trial.pdf admin 18 Jul, 2022 09:02 236.26 Kb 65
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