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Overview Alzheimer's-Cognition and Vitamin D



A summary of the key points of this page by Claude2 - July 2023

The PDF provides an overview of the evidence linking vitamin D deficiency to increased risk of Alzheimer's disease and cognitive decline. It highlights numerous studies, facts, and observations supporting vitamin D's role in brain health.

Some key facts presented:

  • Cognitive decline is 19 times more likely with low vitamin D levels.
  • Dementia and Alzheimer's diseases are consistently associated with low vitamin D in many observational studies.
    • Alzheimer's is 2.3 times more likely in the elderly with low D.
  • Every single risk factor for Alzheimer's disease is also a risk factor for low vitamin D.
  • As vitamin D levels in the elderly continue to decline, cognition gets worse.
  • Increasing vitamin D has been observed to improve cognition in some reports.
  • Alzheimer's patients are 3 times more likely to have a malfunctioning vitamin D receptor gene which can prevent vitamin D from getting into cells.

Some key observations:

  • In animal studies, vitamin D has been found to help remove amyloid brain plaque associated with Alzheimer's.
  • Exposure to DDT, which decreases vitamin D, increases Alzheimer's risk by up to 3.8 times.
  • Genes linked to Alzheimer's all also restrict vitamin D function.
  • There are at least 11 ways vitamin D may help reduce Alzheimer's disease risk and pathology.
  • Daily vitamin D supplementation around 4,000 IU improved cognition in Alzheimer's patients in a clinical trial.

In summary, the PDF compilation of references indicates substantial evidence for a link between low vitamin D and increased Alzheimer's and cognitive decline. It advocates vitamin D supplementation as a low-risk, low-cost prevention and treatment strategy. Combining vitamin D with omega-3 is highlighted as another promising approach currently being tested.


VitaminDWiki - Many Neurological Diseases fought by Vitamin D - Dec 2022


VitaminDWiki - Cognitive category contains

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

378 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (50 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392


Dr. Campbell Video on Dementia/Alzheimer's and Vitamin D - July 2023

YouTube 16 minutes
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16+ Items in both categories Cognitive and Vitamin D Receptor


Alzheimer's before symptoms can now be detected, many ways to prevent having symptoms - May 2024

BrainScan - Pioneering Diagnostics to Prevent and Reverse Cognitive Decline 64 minutes, Apollo Health, Dr. Bredesen
Similar to detecting pre-Diabetes allows proactively stopping progression to diabetes.
Perhaps we should call this a test for pre-Alzheimer's
Far better than the gene test which mearly shows the risk of getting Alzheimer's.


13+ VitaminDWik Meta-analyses with ALZHEIMER in title

This list is automatically updated

Items found: 13

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97+ VitaminDWiki pages with ALZHEIMER in the title

This list is automatically updated

Items found: 98
Title Modified
Consensus: Vitamin D deficiency is related to Alzheimers (9 of 10 studies) - May 2024 07 May, 2024
Overview Alzheimer's-Cognition and Vitamin D 26 Mar, 2024
Vitamin D deficiency increases risk of Dementia by 1.4 X and Alzheimer’s by 1.5 X – Meta-analysis March 2024 11 Mar, 2024
Can predict 10% of Alzheimer’s – unable to count dominos dots (then treat early) – Jan 2024 23 Jan, 2024
End of Alzheimer's videos, transcripts and many studies 17 Nov, 2023
Alzheimer's risk 2X less if good diet (and less risk by Omega-3 and or Vitamin D) - Nov 2023 08 Nov, 2023
Alzheimer’s Is Now Optional - Dr. Bredesen video and transcript Sept 2023 12 Sep, 2023
Personalized Lifestyle Intervention reduced cognitive decline (Alzheimer's)- Aug 2023 20 Aug, 2023
The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. 19 Aug, 2023
Alzheimer’s 1.6X more likely if vitamin D is less than 25 ng – meta-analysis July 2023 20 Jul, 2023
Role of Vitamin D in Alzheimer's disease (paywalled) - May 2023 29 May, 2023
.The Role of Vitamin D in Alzheimer's disease – May 2023 29 May, 2023
.The Role of Vitamin D in Alzheimer's disease (behind paywall) – May 2023 29 May, 2023
How Vitamin D fights Alzheimer’s, Parkinson’s, Multiple Sclerosis and Epilepsy – June 2023 23 Apr, 2023
Alzheimer's 40 percent less likely if leafy veggie diet - March 2023 17 Mar, 2023
The Role of Vitamin D in Reducing Risk of Alzheimer’s and Dementia - transcript Dr. Grant March 2023 12 Mar, 2023
Ways to improve the gut microbiome to reduce Alzheimer's disease – Feb 2023 08 Feb, 2023
How Vitamin D fights neurodegeneration (Multiple Sclerosis, Alzheimer’s, Dementia, etc) – Jan 2023 12 Jan, 2023
Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022 06 Jan, 2023
COVID increased seniors risk of Alzheimer's by 1.7X in the next year- Sept 2022 16 Sep, 2022
Alzheimer's disease 9X more likely in females with a poor Vitamin D Receptor – Sept 2022 27 Aug, 2022
Alzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022 11 Aug, 2022
Alzheimer’s delayed 4.7 years by high Omega-3 index (7.6 years if also have APOE-4) June - 2022 17 Jun, 2022
Alzheimer's disease 1.8 X higher risk if poor Vitamin D Receptor (if not take action) - May 2022 11 Apr, 2022
Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022 08 Apr, 2022
Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018 14 Mar, 2022
Alzheimer's 3X higher risk in countries with high meat consumption - 2016 01 Feb, 2022
End of Alzheimer's video and transcript - Oct 2021 09 Nov, 2021
Mutated gene, OAS1, which lowers vitamin D in brain, increases Alzheimers and severe COVID-19 – Oct 2021 15 Oct, 2021
Omega-3 paused Alzheimer's decline - RCT Sept 2021 11 Sep, 2021
2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021 25 Jun, 2021
Medicare kicks-back 6 percent of price of an administered drug to physicians, perhaps 6 billion dollars annually for Aduhelm (Alzheimer’s) drugs 13 Jun, 2021
Vitamin D influences inflammation and Alzheimer’s genes (in mice) – March 2021 09 Apr, 2021
Alzheimer’s Disease risk is 1.9 X higher if Vitamin D deficient- meta-analysis Feb 2020 06 Feb, 2020
Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019 10 Dec, 2019
Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis Nov 2019 16 Nov, 2019
Alzheimer’s cognitive decline is 3X faster if low vitamin D – May 2017 12 Jun, 2019
Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018 01 May, 2019
Resveratrol for Alzheimer's disease – Sept 2017 27 Apr, 2019
Omega-3 helped Alzheimer’s only if good level of B vitamins – RCT April 2019 10 Apr, 2019
Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis March 2019 23 Mar, 2019
8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019 23 Mar, 2019
African Americans are more likely than whites to develop Alzheimer’s (Vitamin D) 29 Jan, 2019
Standard Omega-3 not get past blood-brain barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018 25 Dec, 2018
APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018 12 Dec, 2018
Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis Nov 2018 27 Nov, 2018
Hypothesis: Low Vitamin D is a cause of Alzheimer’s Disease – 2014 23 Nov, 2018
Multiple Sclerosis, Alzheimer’s and Parkinson’s need more than 30 ng of Vitamin D – review Nov 2017 24 Sep, 2018
Alzheimer’s (apoE4) may require more than Omega-3 - May 2017 18 Sep, 2018
Alzheimer’s associated with low sun and low vitamin D – Sept 2018 18 Sep, 2018
Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015 18 Sep, 2018
Hypothesis: Omega-3 reduces Alzheimer’s directly and via the gut – Sept 2018 11 Sep, 2018
Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018 02 Sep, 2018
The Startling Link Between Sugar and Alzheimer's 02 Jun, 2018
Alzheimer’s increase due to less sun or more meat 22 Apr, 2018
Why Alzheimer’s studies using Omega-3 have mixed results – quality, dose size, Omega-6, genes, etc. March 2018 18 Mar, 2018
Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 16 Feb, 2018
Alzheimer's disease – less risk if smarter, higher vitamin D, better genes or less coffee – Dec 2017 08 Dec, 2017
Alzheimer’s, Parkenson’s, and Multiple Sclerosis – vitamin D may prevent and treat – Oct 2017 07 Dec, 2017
Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 23 Nov, 2017
Lymphatic system discovered in brain (what about Multiple Sclerosis, Alzheimer’s, Omega-3 and Vitamin D) – Oct 2017 07 Oct, 2017
Omega-3 found to treat Alzheimer’s and Parkinson’s in animals – Sept 2017 02 Oct, 2017
Alzheimer plaque possibly cleared by Vitamin D – Nov 2017 02 Aug, 2017
Alzheimer's disease most likely will need more than monotherapy such as vitamin D – May 2013 27 Apr, 2017
Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014 05 Mar, 2017
Genes which reduce blood-level vitamin D increase the risk of Alzheimer’s disease – Dec 2016 18 Jan, 2017
Alzheimer’s and Vitamins D, B, C, E, as well as Omega-3, metals, etc. – June 2013 13 Oct, 2016
DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014 13 Oct, 2016
Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014 23 Sep, 2016
Decrease of Alzheimer’s biomarker halted by Resveratrol (perhaps due to vitamin D) – RCT Sept 2015 08 Aug, 2016
Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015 16 Apr, 2016
Poor Cognition and Alzheimer’s Disease both associated with low vitamin D – review May 2015 16 Apr, 2016
Alzheimer risk reduced by combination of memantine and vitamin D (patented) – Jan 2014 16 Apr, 2016
Alzheimer’s patients are genetically 70 percent more likely to be vitamin D in-efficient – Feb 2012 16 Apr, 2016
Alzheimer’s 4X less likely with high level of vitamin D – 2 studies April 2012 16 Apr, 2016
Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013 13 Dec, 2015
Alzheimer's Disease more likely with low vitamin D – meta-analysis Oct 2012 13 Dec, 2015
Off Topic: Heat Shock Proteins (sauna etc) prevent clumping in Alzheimer’s – Oct 2015 24 Oct, 2015
Alzheimer’s Disease is associated with vitamin D and genes – Aug 2015 10 Sep, 2015
Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012 10 Sep, 2015
Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D gene – 2012 10 Sep, 2015
Alzheimer’s may be treated by vitamin D3 and curcumin – March 2012 01 Sep, 2015
Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis Aug 2015 07 Aug, 2015
Alzheimer disease 5X less likely with nonmelanoma skin cancer (lots of vitamin D) – May 2013 01 Aug, 2015
5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 17 Jul, 2015
Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 18 May, 2015
Why vitamin D in Alzheimer's disease - a hypothesis – Jan 2014 16 Nov, 2014
Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 06 May, 2014
Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013 05 May, 2014
Hypothesis – Alzheimer’s Disease results of hormone imbalance (vitamin D etc.) – Jan 2014 15 Jan, 2014
Comparison of Alzheimer's Disease and Parkinson's Disease – Sept 2013 27 Dec, 2013
Vitamin D and MS, ALS, Autism, Alzheimer’s and other nervous system diseases – review Aug 2013 27 Dec, 2013
Alzheimer's disease 30 percent more likely in the 30 years after a low vitamin D test – July 2013 23 Jul, 2013
Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013 22 May, 2013
Alzheimer’s patients not on medication have very low levels of Vitamin D2 – Nov 2012 12 Nov, 2012
Alzheimer disease associated with 2.5 ng less vitamin D – meta-analysis Sept 2012 09 Oct, 2012
Link between diabetes and Alzheimers is probably low vitamin D 26 Sep, 2012
Alzheimer's probability decreased 77 percent with just 51 IU more vitamin D daily – April 2012 16 Sep, 2012

Cognition and Dementia in VitaminDWiki

19Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

200 patients nicely treated for all 3 types of Alzheimer's by adjusting several of 34 variables - Sept 2017

update at The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. including 3 books, latest Aug 2021

Alzheimer’s can also result from gene problems NOT detected by Vitamin D blood tests

Items in both Cognition and Vitamin D Receptor categories

Note above: Alzheimer’s is 3 times more likely if poor VDR

Vitamin D Receptor category has the following

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart


VitaminDWiki - 50 studies in both categories Cognitive and Omega-3

This list is automatically updated


Alzheimer’s might be associated with Herpes virus (which is associated with low Vitamin D) - Feb 2023

Could Alzheimer’s be caused by an infection? The Guardian   Many hints

  • "“When people with herpes were treated with a standard antiviral drug, it decreased their risk of dementia nine-fold.”"
  • "...– examined postmortem brain samples from patients, she found greater amounts of the virus’s DNA than in people who had not died of the disease."
  • "Studies in the UK, France and Scandinavia suggested that people who had been infected with herpes were more likely to get Alzheimer’s. "
  • "...giving people a shingles vaccine seems to lessen their risk of developing Alzheimer’s"

Diets reduce the risk of Alz

Omega-3 stopped mild AD progression - 2006

  • Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial 10.1001/archneur.63.10.1402.
50 VitaminDWiki studies in both categories Omega-3 and Cognition

Alzheimer's patients had lower levels of vitamin D in Cerebrospinal Fluid - Feb 2022

Vitamin D in Alzheimer's Disease: Low Levels in Cerebrospinal Fluid Despite Normal Amounts in Serum
J Alzheimers Dis. 2022 Feb 15. doi: 10.3233/JAD-215536
Jelena Zugic Soares 1 2 3, Jørgen Valeur 3, Jūratė Šaltytė Benth 4 5, Anne-Brita Knapskog 6, Geir Selbæk 2 6 7, Golchin Arefi 8, D Gregor Gilfillan 8, Anita Tollisen 3, Nenad Bogdanovic 6 9, Renate Pettersen 1

Background: Vitamin D insufficiency has been suggested as a dementia risk factor.

Objective: In this cross-sectional, explorative study we investigated whether levels of vitamin D in cerebrospinal fluid (CSF) are lower in patients with positive biomarkers of Alzheimer's disease (AD) compared to cognitively healthy controls and whether polymorphisms of the vitamin D receptor (VDR) gene, FokI, BsmI, ApaI, and TaqI, are associated with levels of vitamin D in CSF and cognition.

Methods: We included 100 patients≥65 years assessed for cognitive impairment and 76 cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D) in both serum and CSF, and VDR polymorphisms were analyzed.

Results: The mean level of 25(OH)D in serum was 78.6 (SD 28.9) nmol/l. While serum levels of 25(OH)D were not significantly different between the groups, CSF levels of 25(OH)D were significantly lower in patients with positive AD core biomarkers (p = 0.001) compared to patients without such biomarkers. Individuals with the BsmI major homozygote genotype had significantly lower results on a 10-word delayed recall test (p = 0.044) and verbal fluency test (p = 0.013), and individuals with the TaqI major homozygote genotype had significantly lower results on a verbal fluency test (p = 0.030) compared to individuals with the corresponding minor homozygote genotype.

Conclusion: Patients with positive AD core biomarkers have low CSF levels of 25(OH)D, despite sufficient serum levels. CSF levels of 25(OH)D do not seem to be affected by any of the four VDR gene polymorphisms. TaqI and BsmI major homozygote genotypes might be at increased risk for development of cognitive decline.


Playing music from a patient's youth helps with dementia, Alzheimer's, Parkinson's

On the WEB

Type 3 Diabetes?] New York Times Sept 2012

    • Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
    • people with diabetes are at least twice as likely to get Alzheimer’s
  • Alzheimer’s Disease as Type 3 Diabetes: Common Pathophysiological Mechanisms between Alzheimer’s Disease and Type 2 Diabetes - Feb 2022 free PDF
  • Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease - Feb 2020 FREE PDF
  • Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease - April 2020 Free PDF
  • Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer’s Disease -|Feb 2023
  • The Full Spectrum of Alzheimer’s Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes May 2019
  • Sugar in Beverage and the Risk of Incident Dementia, Alzheimer’s disease and Stroke: A Prospective Cohort Study - Nov 2020
  • PubMed Alzheimer's AND Insulin in title 475 items as of March 2023
    • "Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages." Oct 2017 free PDF online
    • "Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease." Sept 2017
    • "Insulin resistance in Alzheimer's disease." May 2017
  • Vitamin D and neurology Wikipedia
    has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
  • Alzheimer's nutrient status - July 2014 including vitamin D - attached at the bottom of this page
  • Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
    "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
  • Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
    3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
  • Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
    Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
  • Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
    Yes: should have a gene test, especially if Alz runs in the family
    If you have two copies of APOE4 gene you can be at 12X risk of getting Alzheimer's
    Personal note: I (Henry Lahore) have just one copy of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
    • Supplementing vitamin D, etc virtually eliminates my increased risk
    • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  • Age-adjusted = increase is NOT due to having a larger elderly population

_Dementia death rate - age standardized @is.gd/increasedisease

  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
    Age-adjusted = increase is NOT due to having a larger elderly population

Dementia death rate - age standardized @is.gd/increasedisease

  • 7 Conditions Masquerading As Dementia GreenMed Info Aug 2018
    Does not mention which the 7 are, but does point to huge success at reversing dementia - using major changes - including supplementing with Vitamin B12, vitamin D, CoQ10 and Omega-3
  • From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
    In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: " Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
    Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:


Clinical Trials for Cognition and Vitamin D INTERVENTION


Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
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Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki


Age-adjusted Death rates: Alzheimer's has been increasing the fastest

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Big increase if both parents had Alzheimer's

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54% of ALL people, of all ages, are now "touched" by Alzheimer's

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Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

  • "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
  • "1 in 9 people over age 65 has Alzheimer's Disease"
  • "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimer's' "
  • "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
  • "Total payments for Health Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
    This $236 Billion does NOT include the costs due to caregiving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013

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Alzheimer's in more than half of hospital patients over age 65

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Half of caregiving for 6+ years is due to Alzheimer's or other dementia

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Work changes due to Alzheimer's or Dementia caregiving

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What if we could delay the onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki
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Looks like about half of the people would not have Alzheimer's costs (die sooner?)


Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag


Items in BOTH Cognition and Omega-3 categories


APOE4 gene greatly increases the risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the childbearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki


Small amount of Lithium slows dementia in Alzheimer's


Saffron treats Alzheimer's as well as drugs, but without side affects - June 2021

__Saffron Put to the Test for Alzheimer’s Dr. Greger

  • Study was funded by BIG SAFRON = Iran (not BIG PHARMA)
  • Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types - June 2020 https://doi.org/10.1111/jfpp.14629 FREE PDF
  • Note: Various suppliers of Safron in combination with Vitamin D

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017


Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

  • Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
    "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
    For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
    VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
  • Bill Gates' newest mission: Curing Alzheimer's CNN
    "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"
  • Why Bill Gates-backed a $30 million fight against Alzheimer’s July 2018
    give profit incentive to groups deploying early detection of Alzheimer's
    His family (father?) has Alzheimer's

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10-year experiment, full free text online
Speed of processing training results in lower risk of dementia


Types of Mental Disorders (no mention of low vitamin D) - 2017?

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Bipolar Bandit has detailed descriptions and references


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Alzheimer's risk reduced by Vit D, Vit C, Omega-3, Zinc, etc more than cancels the increased risk due to APOE-4 problems - July 2018

Why Is Modern Medicine Aiming To Reduce Risk For Alzheimer's Disease With Expensive Gene Editing Technology When Fish Oil, Antioxidants & Metal Chelation Are More Effective & Economical? Bill Sardi

  1. The alternative therapies cancel the increased risk of Alzheimer's due to gene problems
    Gene Therapy ignores the other causes of Alzheimer's and other forms of dementia
  2. The alternative therapies are far far less costly than gene therapy
    might cost $200 Billion to provide gene therapy to everyone with the APOE-4 gene problem

Copper + saturated fat (cholesterol) found to increase the rate of Cognitive Decline by 3X


Alzheimer's rate is especially increasing in groups at high risk of Low Vitamin D (Dark Skin)

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reference for both graphics


Hallmarks of Alzheimer's Are Stimulated by This Substance Mercola
Interview of Boyd Haley, Ph.D., Video and Transcript

  • {...enzyme creatine kinase, which is a fundamental enzyme, is 98 percent inhibited in Alzheimer's patients..."
  • "All Biochemical Abnormalities and Hallmarks of Alzheimer's Are Stimulated by Mercury"
  • In 2014 Haley wrote a paper "Evidence Supporting a Link Between Dental Amalgams and Chronic Illness, Fatigue, Depression, Anxiety and Suicide."
  • "The Relationship of Toxic Effects of Mercury to Exacerbation of the Medical Condition classified as Alzheimer’s Disease" byHaley

>12 million will have Alzheimer’s in the US in 2050

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web


Saffron as good as Alzheimer's drug, but without the side effects - June 2021

  • Saffron Put to the Test for Alzheimer’s Dr Greger
    • Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial - 2014
    • Note: As of June 2021 various suppliers produce Safron in combination with Vitamin D
    • Also:"Co-encapsulation of vitamin D3 and saffron petals’ bioactive compounds in nanoemulsions: Effects of emulsifier and homogenizer types" - June 2020 - https://doi.org/10.1111/jfpp.14629 PDF costs $14

Rates of Death due to Alz and Dementia vary a lot between countries

Image
World Heath Rangings July 2021
Example: US death rate is 6X of that of Japan (34.8 vs 5.2)


Daily multivitamin slowed cognitive decline by 60%: placebo-controlled trial - Nov 2021

Multivitamins, but not cocoa, tied to slowed brain aging MDEdge Nov 11, 2021
Better and better during the trial, but plateaued at 2 years
Presented at a conference. A comment was made that the benefit might be from Vitamin B12 in the multivitamin


Calcitriol appears to worsen Alzheimer's in both mice and humans - 2022

 Download the PDF from VitaminDWiki


Title change made Nov 2021 caused the visitor count to reset.
There have actually been 174457 visitors to this page since it was originally made

60% reduced decline in moderate Alzheimer's symptoms by just diluting blood with water - Feb 2024

Can Getting Transfusions of Young Blood Slow Aging? Dr. Greger video
Transcript
Vampires 2.0? The ethical quandaries of young blood infusion in the quest for eternal life.” In an episode of the TV series Silicon Valley entitled “The Blood Boy,” a tech guru hires a young assistant from whom to transfuse pints of blood in an attempt to slow down his aging. The restoration of youth by bathing in or drinking the blood of youth is a centuries-old trope dating back at least to the futile attempt of ailing Pope Innocent VIII, who in the 1490s failed to live up to his name by apparently drinking the blood of three ten-year-old boys who—though a bargain “costing only one ducat apiece’’—died in the process.

Might there be something to it, though? Though young blood did not have a significant impact on lifespan otherwise, infusing the blood of young animals into old did have rejuvenating effects on multiple organs, similar to full-blown parabiosis, as I talked about in the last video. In fact, not only does the infusion of young mouse blood improve age-related cognitive dysfunction in old mice, young human blood—taken from umbilical cords—worked too (in mice engineered to not reject the foreign tissue). This led to ongoing clinical trials offering weekly infusions of blood products from young donors to patients with mild to moderate Alzheimer’s disease. But there may be an easier way.

Yes, the injection of blood from young mice into old can improve memory and learning, suggesting there’s some kind of restorative youth factor. But the injection of blood from old mice into young can worsen memory and learning, suggesting that instead there’s some sort of debilitating aging factor. Or maybe the old blood is just diluting the revitalizing factor in the young mouse. Or, for that matter, maybe the young blood is diluting the debilitating factor in the old mouse. The fact that old blood appears to make things worse more than young blood makes them better suggests maybe the latter is the case. But you don’t know until you put it to the test.

Ready for a mind-blowing shift in perspective? Instead of infusing young blood into old mice, researchers at UC Berkeley just diluted the blood of old mice by siphoning off the plasma (the liquid portion of the blood), and essentially replacing half of it with water. If the regeneration seen in heterochronic parabiosis and blood transfusions was due to some fountain of youth factor in young blood, then nothing should happen, right? But if all the young blood was doing was diluting some debilitating aging factor, then the water should work just as well. And it did. The rejuvenation in the liver was similar to parabiosis or transfusion, and in the muscles and the brain, it was even better. So, most, if not all, the benefits could be replicated by simple dilution, including an improvement in cognitive capacity.

That’s good news, since there’s already an FDA-approved procedure in use today known as therapeutic plasma exchange. It’s usually used to filter out toxins or autoimmune antibodies, but why not try using it to try to dilute old blood to treat Alzheimer’s disease? And that’s exactly what researchers did.

Hundreds of Alzheimer’s patients were randomized to a therapeutic plasma exchange procedure or a placebo (sham) procedure. And though it didn’t seem to help those with mild Alzheimer’s disease, those with moderate Alzheimer’s randomized to the real procedure experienced about 60 percent less cognitive and functional decline over a period of 14 months. This is in stark contrast to mainstay treatments for Alzheimer’s, like the drug memantine, that can help with symptoms but don’t actually alter the course of the disease. And the added advantage over blood transfusions, as a Director of an Institute of Biomedical Ethics put it: “There is something peculiar about the old literally feeding on the young.”
References

  • Kim TW, Park SS, Park JY, Park HS. Infusion of plasma from exercised mice ameliorates cognitive dysfunction by increasing hippocampal neuroplasticity and mitochondrial functions in 3xtg-ad mice. Int J Mol Sci. 2020;21(9):3291.
  • Ma J, Gao B, Zhang K, et al. Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. Brain Res Bull. 2019;153:15-23.
  • Lavazza A, Garasic M. Vampires 2.0? The ethical quandaries of young blood infusion in the quest for eternal life. Med Health Care Philos. 2020;23(3):421-432.
  • Kang S, Moser VA, Svendsen CN, Goodridge HS. Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer’s disease. Commun Biol. 2020;3(1):69.
  • Learoyd P. The history of blood transfusion prior to the 20th century--part 1. Transfus Med. 2012;22(5):308-314.
  • Shytikov D, Balva O, Debonneuil E, Glukhovskiy P, Pishel I. Aged mice repeatedly injected with plasma from young mice: a survival study. Biores Open Access. 2014;3(5):226-232.
  • Biller-Andorno N. Young blood for old hands? A recent anti-ageing trial prompts ethical questions. Swiss Med Wkly. 2016;146:w14359.
  • Fernández-Zarzoso M, Gómez-Seguí I, de la Rubia J. Therapeutic plasma exchange: Review of current indications. Transfus Apher Sci. 2019;58(3):247-253.
  • Mehdipour M, Mehdipour T, Skinner CM, et al. Plasma dilution improves cognition and attenuates neuroinflammation in old mice. Geroscience. 2021;43(1):1-18.
  • Mehdipour M, Skinner C, Wong N, et al. Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin. Aging (Albany NY). 2020;12(10):8790-8819.
  • Loeffler DA. Ambar, an encouraging alzheimer’s trial that raises questions. Front Neurol. 2020;11:459.
  • Rebo J, Mehdipour M, Gathwala R, et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat Commun. 2016;7:13363.
  • Castellano JM, Mosher KI, Abbey RJ, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544(7651):488-492.
  • Boada M, López OL, Olazarán J, et al. A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer’s disease: Primary results of the AMBAR Study. Alzheimers Dement. 2020;16(10):1412-1425.


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Attached files

ID Name Comment Uploaded Size Downloads
19840 Campbell Alz.jpg admin 26 Jul, 2023 38.85 Kb 911
19332 Calcitriol worse Alzheimers_CompressPdf.pdf admin 10 Mar, 2023 527.63 Kb 172
15976 Dimentia Death Ratee - female.jpg admin 27 Jul, 2021 62.26 Kb 3252
15742 Alz predicted prevalence.jpg admin 13 Jun, 2021 41.38 Kb 3300
13318 Boyd Haley Alz.pdf admin 12 Jan, 2020 2.50 Mb 1112
10890 Alz 2030.jpg admin 23 Nov, 2018 53.79 Kb 7062
10889 Alz dark skin.jpg admin 23 Nov, 2018 38.32 Kb 7132
9924 Mental disorders.jpg admin 04 Jun, 2018 165.44 Kb 8194
9546 Dementia vs Alzheimer's.jpg admin 19 Mar, 2018 55.26 Kb 9730
7796 ALZ Fig 2.jpg admin 05 Mar, 2017 21.45 Kb 13550
7795 Therapeutic Benefit is in the D-Tails.pdf admin 05 Mar, 2017 523.25 Kb 1111
7627 Survival Of The Sickest - 2008 book.pdf admin 06 Jan, 2017 947.50 Kb 12433
7553 Lithium to the Rescue.pdf admin 23 Dec, 2016 670.40 Kb 1805
7407 Lithium as Nutrient - 2015.pdf admin 29 Nov, 2016 128.16 Kb 2047
7406 Lithium and Alz LEF Dec 2016.pdf admin 28 Nov, 2016 3.40 Mb 2380
7256 If delay onset by 5 years.jpg admin 29 Oct, 2016 15.97 Kb 11299
7255 Delay Alz by 5 years - 2015.pdf admin 29 Oct, 2016 1,015.63 Kb 2438
7254 Work changes due to Alz or Dimentia care-giving.jpg admin 29 Oct, 2016 19.54 Kb 11544
7253 Half of care giving for 6+ years is due to Alzheimer's or other dementia.jpg admin 29 Oct, 2016 38.45 Kb 11323
7252 Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013.jpg admin 29 Oct, 2016 21.84 Kb 11911
7251 Alz in more than half of hospital patients over age 65.jpg admin 28 Oct, 2016 37.59 Kb 12083
7250 Alzheimers Association facts and figures 2016.pdf admin 28 Oct, 2016 2.07 Mb 3572
7249 Alzheimer's dark skin.jpg admin 28 Oct, 2016 23.01 Kb 2940
7248 54% touched by Alzheimer's.jpg admin 28 Oct, 2016 23.94 Kb 11322
7247 Alzheimer's both parents.jpg admin 28 Oct, 2016 31.71 Kb 12450
4867 Dementia incidence.jpg admin 12 Jan, 2015 61.75 Kb 11487
4095 Alz nutrient status.pdf admin 29 Jun, 2014 1.57 Mb 2281
3475 Death rates alzheimers.gif admin 02 Jan, 2014 38.58 Kb 26301
3469 Alzheimers percentage.png admin 29 Dec, 2013 49.40 Kb 33733
1131 Alzheimer\'s 2011.pdf admin 04 Mar, 2012 1.09 Mb 7954
1130 Alz in hospital - 2011.jpg admin 04 Mar, 2012 34.72 Kb 9958
1129 Alz how long - 2011.jpg admin 04 Mar, 2012 28.67 Kb 9565
1128 Alz F5 - 2011.jpg admin 04 Mar, 2012 20.73 Kb 9876
1120 Potential targets for Alz.jpg admin 26 Feb, 2012 21.24 Kb 12242
1119 Vitamin D-mentia.pdf admin 26 Feb, 2012 292.71 Kb 3176