Table of contents
- Correlated downregulation of VDR and CYP3A4 in colorectal cancer
- Butyrate upregulates VDR in the colon
- VitaminDWiki -Some diseases reduce vitamin D getting to blood or cells
- VitaminDWiki - Vitamin D Receptor deactivated by some health problems - many studies
- VitaminDWiki - Genetics chart shows the vitamin D genes
- VitaminDWiki -
13 studies in both categories Colon Cancer and Vitamin D Receptor - 81 VitaminDWiki VDR pages have CANCER in title (as of Dec 2022)
- VitaminDWiki -
7 studies in both categories Colon Cancer and Genetics - VitaminDWiki - Cancer - Colon category contains
- References
Correlated downregulation of VDR and CYP3A4 in colorectal cancer
Mol Biol Rep . 2022 Dec 5. doi: 10.1007/s11033-022-08141-2 PDF is behind a paywall
Hossein Sadeghi 1 , Veys Hashemnia 2 , Ehsan Nazemalhosseini-Mojarad 3 , Mohammad Reza Ghasemi 2 , Reza Mirfakhraie 4 5Background: The evidence obtained from experimental studies suggests the tumor-suppressive effects of vitamin D by controlling the differentiation, proliferation, and apoptosis in cancerous cells. Furthermore, the deregulation of genes involved in vitamin D metabolism has been reported in several types of cancer.
Methods: In the present study, we investigated the expression level of vitamin D metabolic pathway genes, including VDR, CYP3A4, RXRa, and GC, in colorectal cancer (CRC) samples compared with the adjacent tissues by using quantitative RT-PCR.
Results: The results indicated significant downregulation of CYP3A4 and VDR genes in CRC tissues compared with the adjacent control tissues (p < 0.01). RXRA and GC expression levels did not show any significant alteration among the studied samples. Moreover, a positive correlation was observed between the expression level of CYP3A4 and VDR genes (p < 0.0001). ROC curve analysis also revealed the potential diagnostic power of CYP3A4 and VDR genes in CRC samples.
Conclusion: Reduction in the expression of both CYP3A4 and VDR plays an important role in CRC due to the possible impairment in vitamin D metabolism. Further studies concerning the relationship between the expression of these genes and colorectal cancer pathogenesis and treatment are recommended.
Butyrate upregulates VDR in the colon
14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement)
VitaminDWiki -Some diseases reduce vitamin D getting to blood or cells
Some diseases restrict vitamin D by changing gene activation,
by one or more of the following- Restrict conversion of light into vitamin D in the skin
- Restrict oral absorption in the gut
- Restrict semi-activation in the liver
- Restrict free semi-activated vitamin D from getting to the kidneys
- Restrict full activation in the kidneys
- Restrict semi and fully activation in the cells
- Restrict activated Vitamin D from entering cell mitochondria (VDR)
- Destroy the vitamin D before it gets to the cells
Some diseases restrict vitamin D without changing genes
- The disease just uses/consumes the vitamin D
- The disease upsets the gut, which reduces bioavailability of oral form
- unless a gut-friendly form is used
References
- COVID changes 100 vitamin D-related genes in the lungs
- Reasons for low response to vitamin D
- Genetics category has
342 items along with related searches - The risk of 44 diseases at least double with poor VDR as of Oct 2019
VitaminDWiki - Vitamin D Receptor deactivated by some health problems - many studies
VitaminDWiki - Genetics chart shows the vitamin D genes
CYP3A4 (7 as of Dec 2022)
VitaminDWiki -
13 studies in both categories Colon Cancer and Vitamin D Receptor This list is automatically updated
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- 14th activator of the Vitamin D Receptor – Butyrate (from gut bacteria, or supplement)
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020
- Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Advanced Colon Cancer risk is doubled or halved with 1000 IU of Vitamin D, depends on Vitamin D Receptors – RCT May 2017
- Colon Cancer survival 3.1 X less likely if poor Vitamin D Receptor – Aug 2017
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012
81 VitaminDWiki VDR pages have CANCER in title (as of Dec 2022)
This list is automatically updated
Items found: 71
VitaminDWiki -
7 studies in both categories Colon Cancer and Genetics This list is automatically updated
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019
- Many Ashkenazi Jewish diseases associated with low vitamin D or poor Vit D genes
- Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- Colorectal cancer – need more vitamin D if you have certain genes – Aug 2013
- Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014
- Gene variations were not associated with risk of colorectal cancer in Czech – June 2010
VitaminDWiki - Cancer - Colon category contains
- Cancer - Colon category listing has
142 items - see also:
Overview Cancer-Colon and vitamin D. Overview Cancer and vitamin D Overview Gut and vitamin D Cancer and Vitamin D - many studies - Cancer - After diagnosis category listing has
113 items along with related searches - 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
- Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
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- Sadeghi H, Kamaliyan Z, Mohseni R, Sahebi U, Nazemalhosseini-Mojarad E, Aghaei N et al (2021) Dysregulation of vitamin D synthesis pathway genes in colorectal cancer: a case-control study. J Clin Lab Anal 35(2):e23617 - DOI - PubMed
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Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 20222203 visitors, last modified 12 Mar, 2024, This page is in the following categories (# of items in each category)
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