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Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021

Correlative Analysis of Vitamin D and Omega-3 Fatty Acid Intake in Men on Active Surveillance for Prostate Cancer

Urology. 2021 Jun 15;S0090-4295(21)00525-2. doi: 10.1016/j.urology.2021.04.050
Rebecca A Campbell 1, Jianbo Li 2, Lindsay Malone 3, David A Levy 4


Vitamin D and Omega-3 category starts with

346 Omega-3 items in category Omega-3 and Vitamin D separately & together help with: Autism (9 studies), Depression (24 studies), Cardiovascular (30 studies), Cognition (45 studies), Pregnancy (33 studies), Infant (23 studies), Obesity (12 studies), Mortality (5 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), etc

   See also - Overview: Omega-3 many benefits include helping vitamin D

Items in both categories Prostate Cancer and Omega-3:

Prostate Cancer in VitaminDWiki

Prostate Cancer and Vitamin D studies
Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019
Reduce Prostate Cancer Risk: 1.3 X if eat specific plants, 1.7X if add Vitamin D
The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019
Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018

Less vitamin D gets to cells (such as Prostate) if have a poor Vitamin D Receptor

Vitamin D Receptor category has the following

411 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Chart via Google Images

Objectves: To investigate the influence of targeted serum vitamin-D level and omega-6:3 fatty-acid ratio on prostate-specific antigen (PSA) level in men with prostate cancer managed with active surveillance by providing a nutritional intervention and vitamin supplementation.

Methods: Sixty-eight patients with biopsy-proven NCCN very-low or low-risk prostate cancer were enrolled in the prostate cancer nutrition and genetics clinic at the Cleveland Clinic from July 2013-December 2019. Patients adhered to a specific dietary regimen devoid of animal-based products and foods containing omega-6 polyunsaturated fatty acids (PUFAs). The supplement regimen consisted of: Omega-3 PUFAs 720mg (three/day); curcumin 2000 mg/day; vitamin D3 dose titrated to achieve serum level of 60 ng/ml; and vitamin B-complex 1000 mg (four times weekly). Patients underwent periodic monitoring of PSA, serum vitamin D, and PUFA levels and had frequent follow-up with the nutritionist which included a food frequency questionnaire. Interval prostate biopsy was performed as clinically indicated and/or at nine months.

Results: The mean and 95% confidence interval (CI) of PSA slope and Vitamin D serum levels slope were 0.11 (0-0.25) ng/mL/month and 4.65 (3.09-5.98) ng/mL/month, respectively. Patients with higher initial vitamin D levels were twice as likely to have a downward PSA trend (OR=2.04, 95% CI 1.04-4.01, p=0.04). Fifty-five patients underwent follow-up biopsy, all showing no progression of disease. Three patients had loose bowel movements that required omega-3 and or curcumin dose adjustments.

Conclusions: Intensive nutritional intervention with Vitamin D and Omega-3 PUFA supplementation may benefit men on active surveillance for prostate cancer and further studies are warranted.

PDF costs $36


IARC Publications Website - World Cancer Report 2014. Accessed July 30, 2020. https://publications.iarc.fr/Non-Series-Publications/World-Cancer-Reports/World-Cancer-Report-2014
Surveillance, Epidemiology, and End Results (SEER). Cancer Statistics Review (CSR). Accessed July 31, 2020. https://seer.cancer.gov/archive/csr/1975_2013/
Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part I: Risk Stratification, Shared Decision Making, and Care Options.
J Urol. 2018; 199: 683-690 https://doi.org/10.1016/j.juro.2017.11.095
Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden); Cancer Causes Control. 1998; 9: 559-566 https://doi.org/10.1023/A:1008823601897
Glycemic index, glycemic load and risk of prostate cancer. Int J Cancer. 2004; 112: 446-450 https://doi.org/10.1002/ijc.20416
A prospective study of dietary fat and risk of prostate cancer - PubMed.J Natl Cancer Inst. 1993; 85 (Accessed July 31, 2020): 1571-1579
Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr Cancer. 2011; 63: 860-872 https://doi.org/10.1080/01635581.2011.582224
Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade. Int J Cancer. 2012; 131: 1187-1196
Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study. Cancer Causes Control. 2015; 26: 205-218 https://doi.org/10.1007/s10552-014-0500-5
Vitamin D deficiency predicts prostate biopsy outcomes. Clin Cancer Res. 2014; 20: 2289-2299 https://doi.org/10.1158/1078-0432.CCR-13-3085
Dietary PUFA and cancer. in: Proceedings of the Nutrition Society. 73. Cambridge University Press, 2014: 361-367
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.J Clin Invest. 2007; 117: 1866-1875 https://doi.org/10.1172/JCI31494
Docosahexaenoic acid induces proteasome-dependent degradation of β-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis. 2006; 28: 1202-1209
Dietary fat-gene interactions in cancer.
Cancer Metastasis Rev. 2007; 26: 535-551
et al.
Prostate cancer, version 2.2019.
JNCCN J Natl Compr Cancer Netw. 2019; 17: 479-505
View in Article
Scopus (348)
Google Scholar
Food Frequency Questionnaire at a Glance | Dietary Assessment Primer. Accessed August 3, 2020. https://dietassessmentprimer.cancer.gov/profiles/questionnaire/

View in Article
Google Scholar
Subar AF
Thompson FE
Kipnis V
et al.
Comparative validation of the Block, Willett, and National Cancer Institute Food Frequency Questionnaires: The Eating at America's Table Study.
Am J Epidemiol. 2001; 154: 1089-1099
View in Article
Scopus (909)
Google Scholar
Garland CF
French CB
Baggerly LL
Heaney RP.
Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention.
Anticancer Research. 2011; (PublishedAccessed July 29, 2020)
View in Article
Google Scholar
Jingwi EY
Abbas M
Ricks-Santi L
et al.
Vitamin D receptor genetic polymorphisms are associated with PSA level, gleason score and prostate cancer risk in african-american men.
Anticancer Res. 2015; 35 (Accessed October 12, 2020. /pmc/articles/PMC4743656/?report=abstract): 1549-1558
Circulating vitamin D, vitamin D-related genetic variation, and risk of fatal prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Cancer. 2015; 121: 1949-1956
Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer.
Br J Cancer. 2010; 102: 403-413
Glycemic index, glycemic load and cancer risk - ScienceDirect. Accessed July 30, 2020. https://www.sciencedirect.com/science/article/pii/S0923753419370346
Are strict vegetarians protected against prostate cancer?.
Am J Clin Nutr. 2016; 103: 153-160
The importance of the ratio of omega-6/omega-3 essential fatty acids.
Biomed Pharmacother. 2002; 56: 365-379
Characteristics of fats in Japanese diets and current recommendations. Lipids. 1996; 31: S283-S286 https://doi.org/10.1007/bf02637092
A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutr Res. 2011; 31: 1-8
Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res. 2011; 4: 2062-2071 https://doi.org/10.1158/1940-6207.CAPR-11-0298
Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy.
Cancer Prev Res. 2014; 7: 97-104
Curcumin inhibits Cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling.
Int J Oncol. 2015; 47: 2064-2072
Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells.
PLoS One. 2015; 10

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