- Loss of vitamin D receptor induces premature ovarian insufficiency through compromising the 7-dehydrocholesterol-dependent antiaging effects
- VitaminDWiki - IVF 4X more successful for white women with lots of vitamin D – many studies
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25 studies in both categories Pregnancy and Vitamin D Receptor - VitaminDWiki -
8 studies in both categories Fertility and Vitamin D Receptor
Loss of vitamin D receptor induces premature ovarian insufficiency through compromising the 7-dehydrocholesterol-dependent antiaging effects
Front. Cell Dev. Biol.Sec. Molecular and Cellular Pathology Volume 13 - 2025
doi: 10.3389/fcell.2025.1545167 PDF probably will be available in June
Haiyun Chen Haiyun Chen 1,2Qiuyi Wang Qiuyi Wang 3Luxi Shangguan Luxi Shangguan 1,2Zhengquan Zhu Zhengquan Zhu 1,2Huan Zhang Huan Zhang 1,2Xiang Zou Xiang Zou 4Qinghe Geng Qinghe Geng 5,6*Yanting Wen Yanting Wen 1,2*Daojuan Wang Daojuan Wang 7*Yong Wang Yong Wang 1,2,8*Vitamin D has the potential to therapeutically affect the endocrine parameters of premature ovarian insufficiency (POI) patients. Previous research has indicated that serum vitamin D levels tend to decline with age and in individuals with POI. However, the precise impact of vitamin D deficiency on female fertility, especially their ovarian function, remains unclear.
Vitamin D receptor (VDR) deficiency mice provide a model to investigate the possible effect of vitamin D on female reproduction. In this study, we observed abnormal follicular development in the Vdr deficiency mice. This anomaly is associated with reduced expression of anti-Mullerian hormone (AMH) and disrupted aromatase expression that disrupts the hormone secretion. Moreover, our findings indicate that Vdr deficiency disturbs redox balance, resulting in oxidative stress in the ovary, which further suppresses granulosa cell function and accelerates ovarian aging.
Mechanistically, loss of Vdr inhibits de novo cholesterol synthesis by transcriptional repression of Hmgcr, and the antioxidant and anti-aging effects of the intermediate product 7-dehydrocholesterol (7-DHC) are also decreased. Treatment with 7-DHC effectively reduces ROS levels and alleviates aging in KGN cells deficient in Vdr.
In conclusion, our results show that Vdr deficiency impairs follicle maturation and hormone secretion by accelerating granulosa cell aging, as a result of the reduced antioxidant and anti-aging effect of 7-DHC.
VitaminDWiki - IVF 4X more successful for white women with lots of vitamin D – many studies
VitaminDWiki -
25 studies in both categories Pregnancy and Vitamin D Receptor This list is automatically updated
- Perhaps increased need for IVF if poor vitamin D receptor – April 2025
- Gestational Diabetes and Vitamin D - many studies
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Preeclampsia reduced by Vitamin D - many studies
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone activates vitamin D receptor - many studies
VitaminDWiki -
8 studies in both categories Fertility and Vitamin D Receptor This list is automatically updated
- Perhaps increased need for IVF if poor vitamin D receptor – April 2025
- In vitro fertilization and Vitamin D – many studies
- Infertility risk increased 2.5 X by poor Vitamin D Receptor – July 2023
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- Male Infertility is associated with poor Vitamin D Receptor – July 2021
- Poor male fertility is association with poor Vitamin D Receptor (less D to the cells) – July 2021
- Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
- PCOS (polycystic ovary syndrome) 4 times more likely if poor Vitamin D Receptor – Dec 2015
Perhaps increased need for IVF if poor vitamin D receptor – April 2025Printer Friendly Follow this page for updates57 visitors, last modified 04 Apr, 2025, This page is in the following categories (# of items in each category) - VitaminDWiki -