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Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023


Recent progress in nanotechnology-based drug carriers for resveratrol delivery

Drug Delivery Volume 30, 2023 - Issue 1 https://doi.org/10.1080/10717544.2023.2174206
Chunhong Li,Zhen Wang,Hui Lei &Dan Zhang

Image
AuC: area under the concentration-time curve (plasma exposure);
t1/2: plasma half life;    Cl: clearance;
MrT: mean residence time;    Cmax: peak plasma concentration;
AuC0 →∞: area under the concentration time-curve from time zero to infinity;

Forms
Image
Resveratrol is a polyphenol with diverse pharmacological activities, but its clinical efficacy is limited due to low solubility/permeability, light-induced isomerization, auto-oxidation, and rapid metabolism. Nanodelivery systems, such as liposomes, polymeric nanoparticles, lipid nanocarriers, micelles, nanocrystals, inorganic nanoparticles, nanoemulsions, protein-based nanoparticles, exosomes, macrophages, and red blood cells (RBCs) have shown great potential for improving the solubility, biocompatibility, and therapeutic efficacy of resveratrol. This review comprehensively summarizes the recent advances in resveratrol nanoencapsulation and describes potential strategies to improve the pharmacokinetics of existing nanoformulations, enhance targeting, reduce toxicity, and increase drug release and encapsulation efficiency. The article also suggests that in order to avoid potential safety issues, resveratrol nanoformulations must be tested in vivo in a wide range of diseases.
 Download the PDF from VitaminDWiki
Note: Neither Vitamin D nor Vitamin D receptor occur in the PDF


VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators


VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) contains

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
  • Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratro
18 articles in both of the categories Resveratrol and Vitamin D Receptor

VitaminDWiki – Vitamin D Receptor category contains

507 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (35 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR


Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk
increase
Health Problem
50Lyme Disease *
28Leprosy - another says 3X
15Chronic Heart Failure
15Temporary hair loss
14,7Childhood solid cancers
14Hand, Foot, and Mouth disease
13Sepsis
12COVID Death
11Metabolic Syndrome
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
5Asthma Child see also 1.3, 2.0 and 3.6
4.6Breast Cancer * 16.9 X another study
4.3Severe COVID in kids
4.1Vitiligo
4Polycystic ovary syndrome
3.8Lupus
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
9X in women
3Parkinson’s
3Gestational Diabetes
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Cardio
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma see also 5X
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
2Preeclampsia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Gout
1.5Pertussis
1.5Obesity
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Hypertension
1.3Childhood asthma see also 5X
1.3Psoriasis in Caucasians
1.3Tuberculosis
?? Rickets - Vitamin D resistant

Many Amazon suppliers sell liposomal Resveratrol

Amazon
Some of the items listed are liposomal tumeric/curcumin combined with Reseratrol (probably OK)
Ignore the non-liposomal products (wonder how trans compares to liposomal)
Founder of VitaminDWiki bought NATURE'S ESSENTIALS July 2023
Note: A DNA test disclosed that both he and his wife have poor Vitamin D Receptors


Resveratrol increases the cellular Vitamin D by activating the VDR

in Visio for 2023
click here for details


Chat-GPT comparision of Trans and Liposomal forms - July 2023

  • Liposomal resveratrol is a formulation that encapsulates resveratrol in liposomes - small spherical vesicles made from phospholipids. This formulation is aimed at improving the bioavailability of resveratrol, meaning that it may be better absorbed and stay in the bloodstream for a longer period of time compared to non-encapsulated resveratrol.
  • Here is a comparison between liposomal resveratrol and trans-resveratrol:
  • Bioavailability: Liposomal resveratrol is thought to have higher bioavailability compared to regular trans-resveratrol. The liposomal encapsulation is intended to protect resveratrol from degradation in the digestive system and facilitate its absorption into the bloodstream.
  • Effectiveness: Due to the increased bioavailability, liposomal resveratrol may be more effective at delivering the potential health benefits of resveratrol.
  • Cost: Liposomal formulations are generally more expensive to produce, so liposomal resveratrol supplements may be more expensive compared to regular trans-resveratrol supplements.
  • Research and Evidence: As of 2021, there is a considerable amount of research on trans-resveratrol, but limited research on liposomal resveratrol. It’s important to note that while the liposomal form might offer better bioavailability, further studies are needed to confirm its long-term efficacy and safety.
  • Administration and Dosage: Liposomal resveratrol is usually available in liquid form, which might be easier for some people to take compared to capsules or tablets of trans-resveratrol.



Attached files

ID Name Comment Uploaded Size Downloads
19746 Res improvements.jpg admin 04 Jul, 2023 57.33 Kb 115
19745 Res Nano forms.jpg admin 04 Jul, 2023 91.49 Kb 116
19744 Res ToC.jpg admin 04 Jul, 2023 18.88 Kb 34
19743 nanotechnology-based resveratrol_CompressPdf.pdf admin 04 Jul, 2023 439.18 Kb 74