- Recent progress in nanotechnology-based drug carriers for resveratrol delivery
- VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
- VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) - many studies contains
- VitaminDWiki – Vitamin D Receptor category contains
- 55 health problems associated with poor VDR
- How to increase VDR activation
- Diseases associated with a poor Vitamin D Receptor
- Many Amazon suppliers sell liposomal Resveratrol
- Resveratrol increases the cellular Vitamin D by activating the VDR
- Chat-GPT comparision of Trans and Liposomal forms - July 2023
Recent progress in nanotechnology-based drug carriers for resveratrol delivery
Drug Delivery Volume 30, 2023 - Issue 1 https://doi.org/10.1080/10717544.2023.2174206
Chunhong Li,Zhen Wang,Hui Lei &Dan Zhang
AuC: area under the concentration-time curve (plasma exposure);
t1/2: plasma half life; Cl: clearance;
MrT: mean residence time; Cmax: peak plasma concentration;
AuC0 →∞: area under the concentration time-curve from time zero to infinity;
Forms
Resveratrol is a polyphenol with diverse pharmacological activities, but its clinical efficacy is limited due to low solubility/permeability, light-induced isomerization, auto-oxidation, and rapid metabolism. Nanodelivery systems, such as liposomes, polymeric nanoparticles, lipid nanocarriers, micelles, nanocrystals, inorganic nanoparticles, nanoemulsions, protein-based nanoparticles, exosomes, macrophages, and red blood cells (RBCs) have shown great potential for improving the solubility, biocompatibility, and therapeutic efficacy of resveratrol. This review comprehensively summarizes the recent advances in resveratrol nanoencapsulation and describes potential strategies to improve the pharmacokinetics of existing nanoformulations, enhance targeting, reduce toxicity, and increase drug release and encapsulation efficiency. The article also suggests that in order to avoid potential safety issues, resveratrol nanoformulations must be tested in vivo in a wide range of diseases.
 Download the PDF from VitaminDWiki
Note: Neither Vitamin D nor Vitamin D receptor occur in the PDF
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 16 known VDR activators
VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) - many studies contains
- The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
- Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
- Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
- Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
- Quercetin and Curcumin in the case of Resveratrol
- Resveratrol - liposomal may be best form to increase cellular Vitamin D - Feb 2023
- Resveratrol, which increased Vitamin D in the cell, improves vision – July 2022
- Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Effects of Resveratrol against Lung Cancer in mice – Nov 2017
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Lifespan and healthspan extension by resveratrol - Jan 2015
- Resveratrol for Alzheimer's disease – Sept 2017
- Resveratrol and Cardiovascular Diseases – May 2016
- The Role of Resveratrol in Cancer Therapy – Dec 2017
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Bone density improved with resveratrol (which improves Vitamin D Receptor) – RCT Sept 2018
- Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene – Oct 2017
- Immune system is aided by red grapes, blueberries, both of which increase Vitamin D receptor – 2013
- Vitamin D Receptor
- Resveratol helps vitamin D bind to cells
- Resveratrol gets vitamin D to cells even if poor vitamin D receptor
VitaminDWiki – Vitamin D Receptor category contains
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
Increasing | Increases |
1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
2) Magnesium | Vitamin D in the blood AND in the cells |
3) Omega-3 | Vitamin D in the cells |
4) Resveratrol | Vitamin D Receptor |
5) Intense exercise | Vitamin D Receptor |
6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
7) Quercetin (flavonoid) | Vitamin D Receptor |
8) Zinc is in the VDR | Vitamin D Receptor |
9) Boron | Vitamin D Receptor ?, etc |
10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
11) Progesterone | Vitamin D Receptor |
12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
14) Butyrate especially gut | Vitamin D Receptor |
15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Diseases associated with a poor Vitamin D Receptor
Increased risk associated with a poor Vitamin D Receptor
Note: Some diseases reduce VDR activation
those with a * are known to decrease activation
Many Amazon suppliers sell liposomal Resveratrol
Amazon
Some of the items listed are liposomal tumeric/curcumin combined with Reseratrol (probably OK)
Ignore the non-liposomal products (wonder how trans compares to liposomal)
Founder of VitaminDWiki bought NATURE'S ESSENTIALS July 2023
Note: A DNA test disclosed that both he and his wife have poor Vitamin D Receptors
Resveratrol increases the cellular Vitamin D by activating the VDR
click here for details
Chat-GPT comparision of Trans and Liposomal forms - July 2023
- Liposomal resveratrol is a formulation that encapsulates resveratrol in liposomes - small spherical vesicles made from phospholipids. This formulation is aimed at improving the bioavailability of resveratrol, meaning that it may be better absorbed and stay in the bloodstream for a longer period of time compared to non-encapsulated resveratrol.
- Here is a comparison between liposomal resveratrol and trans-resveratrol:
- Bioavailability: Liposomal resveratrol is thought to have higher bioavailability compared to regular trans-resveratrol. The liposomal encapsulation is intended to protect resveratrol from degradation in the digestive system and facilitate its absorption into the bloodstream.
- Effectiveness: Due to the increased bioavailability, liposomal resveratrol may be more effective at delivering the potential health benefits of resveratrol.
- Cost: Liposomal formulations are generally more expensive to produce, so liposomal resveratrol supplements may be more expensive compared to regular trans-resveratrol supplements.
- Research and Evidence: As of 2021, there is a considerable amount of research on trans-resveratrol, but limited research on liposomal resveratrol. It’s important to note that while the liposomal form might offer better bioavailability, further studies are needed to confirm its long-term efficacy and safety.
- Administration and Dosage: Liposomal resveratrol is usually available in liquid form, which might be easier for some people to take compared to capsules or tablets of trans-resveratrol.
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19743 | nanotechnology-based resveratrol_CompressPdf.pdf | admin 04 Jul, 2023 | 439.18 Kb | 110 |