Egyptian Journal of Medical Human Genetics, http://dx.doi.org/10.1016/j.ejmhg.2016.08.004
Rokhsareh Meamara, b, Seyed Morteza Javadiradc, Niloofar Chitsaza, Mojgan Asadiana, Mahdi Kazemib, Maryam Ostadsharifd, e, , ,
|Aa heterozygous of ApaI vs AA homozygous||7.44|
See also VitaminDWiki
The items in both Parkinson's Disease and Vitamin D Receptor categories are listed here:
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Parkinson's disease cognitive decline associated with poor Vitamin D receptor – Nov 2016
- Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016
- Parkinson's Disease associations with Vitamin D receptor and GC gene (behind paywall) – June 2016
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
Overview Parkinsons and Vitamin D contains the following summary
Parkinson's Disease proven to be TREATED by Vitamin D (Many Meta-analyses of trials)
- Parkinson's disease stabilized with just 1200 IU of vitamin D – RCT May 2013
First RCT to report results - +anticipate far better results when more vitamin D is used.
(Belief based on the results with vitamin D on MS and Diabetes)
Additonal proofs that vitamin D treats or prevents diseases
- 6 clinical trials for PD with vitamin D intervention as of Jan 2016
A person could wait a few years to get the results of the clinical trials, but
- Based on reading more than 4,000 studies of vitamin D at VitaminDWiki
- A (loading) dose of 20,000 IU of vitamin D daily for the 3 weeks should provide observable benefit
To avoid a rare reaction to Vitamin D
take 1,000 IU of vitamin D first, and stop if you you have an allergic reaction withiin 3 days
When continuing to take vitamin D you should also take cofactors
There is virtually no need have a vitamin D test in first 2 months
- Parkinson's category has
84 items Vitamin D Receptor category listing has 394 items along with related searches,
and the following observation
Vitamin D ==> Calcidiol = measured Vitamin D ==> Calcitriol ==> Vitamin D Receptor ==> Cell
Thus you can have a good measured level of vitamin D,
but the Cell does not get as much due to poor Vitamin D Receptor
Background: Vitamin D plays an important role in neurodegenerative disorders as a crucial neuro-immunomodulator. Accumulating data provide evidences that vitamin D receptor (VDR) gene is a candidate gene for susceptibility to Parkinson’s disease (PD).
Aim: To find out whether the risk of the development of sporadic PD might be influenced by VDR gene polymorphisms in an Iranian population or not.
Subjects and methods: A genetic study was conducted to investigate the relationship between VDR gene polymorphisms and the severity of PD. Fifty-nine PD patients and 53 matched-healthy controls were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) analysis. For this purpose, four single nucleotide polymorphisms (SNPs) in VDR gene including FokI T > C (rs 10735810), BsmI A > G (rs 1544410), ApaI A > C (rs 7975232), and TaqI C > T (rs 731236) have been evaluated.
Results: Our genotyping studies revealed that holding ApaI a allele and FokI f allele could significantly increase the risk of developing Parkinson’s disease 1.85 and 2.46 times, respectively (p = 0.023 and 0.008). Moreover, Aa heterozygous of ApaI also shows a significantly elevated risk of developing PD when compared to AA homozygous (OR = 7.44, p = 0.005). For BsmI and TaqI polymorphisms, no significant difference in genotype or allele distribution was found between PD patients and the controls. Moreover, in this study, no significant association was found between different genotypes and Hoehn & Yahr staging and Unified Parkinson Disease Rating Stage (UPDRS) rating scale.
Conclusion: This study demonstrates a possible association between the VDR FokI and ApaI polymorphism and PD, indicating that VDR polymorphisms may change genetic susceptibility to sporadic PD in the Iranian population.
Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016
- Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease
- The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease - Sept 2020
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