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Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)

Deactivation of CYP3A4 by drugs such as Ivermectin INCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs such as some anti-epileptics DECREASE calcitriol and calcidriol (Vitamin D)

  • Ivermectin raises levels of vitamin D (by decreasing CYP3A4)
  • Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities,
    targeting CYP3A4*1G allele function. -  PDF
  • Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - July 2014 -  PDF
    • "For example, daily administration of rifampin (anti-epileptic) to healthy volunteers lowered the plasma concentration of 25OHD3 by 70%"
  • CYP3A4 mutation causes vitamin D–dependent rickets type 3 - Feb 2018 -  PDF
  • Role of vitamin D receptor in the regulation of CYP3A gene expression = Nov 2019 -  PDF

See also Ivermectin and COVID-19

Genetics category listing contains the following

292 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain


  • CYP3A4 Wikipedia
    • CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
    • grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.

Created by admin. Last Modification: Monday July 26, 2021 08:49:27 GMT-0000 by admin. (Version 17)

Attached files

ID Name Comment Uploaded Size Downloads
15692 Role of vitamin D receptor in the regulation of CYP3A gene expression.pdf admin 01 Jun, 2021 15:39 696.56 Kb 166
15691 CYP3A4 rickets.pdf admin 01 Jun, 2021 15:36 1.67 Mb 153
15690 Interplay between Vitamin D.pdf admin 01 Jun, 2021 15:19 548.10 Kb 147
15689 CYP3A4 American Indian.pdf admin 01 Jun, 2021 15:11 302.44 Kb 153
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