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Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)

Deactivation of CYP3A4 by drugs such as Ivermectin INCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs such as some anti-epileptics DECREASE calcitriol and calcidriol (Vitamin D)

See also Ivermectin and COVID-19 - many studies

Genetics category listing contains the following

337 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
        especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) DNA and VDR tests - 120 to 200 dollars $100 to $250
    4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
       Genes are good, have enough Magnesium, etc.
    5) Back Pain
       probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
      • The founder of VitaminDWiki took action with clues #3&5


  • CYP3A4 Wikipedia
    • CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
    • grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.

Created by admin. Last Modification: Friday March 15, 2024 10:36:40 GMT-0000 by admin. (Version 21)

Attached files

ID Name Comment Uploaded Size Downloads
20964 CYP3A4 etc regulated by VDR - 2002.pdf admin 15 Mar, 2024 288.90 Kb 20
15692 Role of vitamin D receptor in the regulation of CYP3A gene expression.pdf admin 01 Jun, 2021 696.56 Kb 413
15691 CYP3A4 rickets.pdf admin 01 Jun, 2021 1.67 Mb 409
15690 Interplay between Vitamin D.pdf admin 01 Jun, 2021 548.10 Kb 327
15689 CYP3A4 American Indian.pdf admin 01 Jun, 2021 302.44 Kb 351