Deactivation of CYP3A4 by drugs such as Ivermectin INCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs such as some anti-epileptics DECREASE calcitriol and calcidriol (Vitamin D)
- Ivermectin raises levels of vitamin D (by decreasing CYP3A4)
- Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
- Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022
- Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities,
targeting CYP3A4*1G allele function. -  PDF - Interplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - July 2014 -  PDF
- "For example, daily administration of rifampin (anti-epileptic) to healthy volunteers lowered the plasma concentration of 25OHD3 by 70%"
- CYP3A4 mutation causes vitamin D–dependent rickets type 3 - Feb 2018 -  PDF
- Role of vitamin D receptor in the regulation of CYP3A gene expression = Nov 2019 -  PDF
See also Ivermectin and COVID-19 - many studies
Genetics category listing contains the following
see also
- Vitamin D Receptor has
499 items - Vitamin D Binding Protein = GC has
174 items - CYP27B1 has
58 items - CYP24A1 in title of 34+ items
- CYP2R1 25+ items
- Calcidiol has
46 items - Calcitriol has
56 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
Web
- CYP3A4 Wikipedia
- CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
- grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.
Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)3465 visitors, last modified 06 Dec, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Comment Uploaded Size Downloads 15692 Role of vitamin D receptor in the regulation of CYP3A gene expression.pdf admin 01 Jun, 2021 15:39 696.56 Kb 346 15691 CYP3A4 rickets.pdf admin 01 Jun, 2021 15:36 1.67 Mb 339 15690 Interplay between Vitamin D.pdf admin 01 Jun, 2021 15:19 548.10 Kb 287 15689 CYP3A4 American Indian.pdf admin 01 Jun, 2021 15:11 302.44 Kb 307 - Vitamin D Binding Protein = GC has