Both Cardiovascular and Cerebrovascular Events are Decreased Following Long-term NB- UVB Phototherapy in Patients with Vitiligo: A Propensity-score Matching Analysis
Journal of the European Academy of Dermatology and Venereology doi: 10.1111/jdv.16830
Jung Min Bae, MD, PhD,1* Yoon-Seob Kim, MD,2* Eun Ho Choo, MD,3 Mi-Yeon Kim MD,4 Jun Young Lee, MD, PhD,5 Hyung-Ok Kim, MD, PhD,6 and Young Min Park, MD, PhD.5
This study is based on 3,000 Koreans following 10 years of UVB treatment
- Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis March 2016
- Spotty skin coloring (vitiligo) treated by augmenting topical tacrolimus with oral Vitamin D – Oct 2016
- Vitiligo (loss of skin pigment) treated by narrowband UVB
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
Items in both categories Vitamin D Receptor and UV are listed here:
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- Vitamin D genes and UVB vary massively across the Eastern Hemisphere – March 2020
- Vitamin D Receptor in vitiligo skin activated by UVB – May 2018
- UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017
- Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010
Items in both categories Skin and UV are listed here:
- Vitiligo associated with low vitamin D (Note: Vit. D and UV has treated it for over a decade) – meta-analysis March 2021
- UVB phototherapy (which increases Vitamin D and VDR) decreased risk of many heart and stroke problems – July 2020
- Sunscreen (SPF-30) slightly increased the vitamin D from UVB – RCT Jan 2019
- Vitamin D Receptor in vitiligo skin activated by UVB – May 2018
- Ultraviolet light (which produces vitamin D) decreased the use of psoriasis drugs for a year – Aug 2017
- Sunburning reduced by 200,000 IU of Vitamin D – RCT April 2017
- Phototherapy and vitamin D – Sept 2016
- Many other anti-cancer photoproducts generated on the skin in addition to vitamin D – Jan 2014
- UVB increases vitamin D even if poor kidney by changing CYP27B1 genes in skin – Dec 2013
- Vitiligo (loss of skin pigment) treated by narrowband UVB
- Eczema not reduced in small study which used narrowband UVB to raise vitamin D levels – Feb 2014
- Dermatologists view of UV radiation and the Skin – June 2013
- Intense UV damages cadaver skin– Oct 2012
- Possible DNA damage of skin if vitamin D levels less than 20 nanograms – April 2012
- For small amounts of sunshine the amount of skin exposed may not matter – Jan 2011
- Overview Skin and vitamin D
Items in both categories Cardiovascular and UV are listed here:
Items in both categories Stroke and Vitamin D Receptor are listed here:
- Resveratrol improves health (Vitamin D receptor, etc.)
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
- Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses (auto-updated)
- Statin pain reduces Vitamin D levels by 4 ng ( 9 studies) - Meta-analysis July 2021
- Arterial stiffness reduced if use at least 2,000 IU of Vitamin D for 4 months – meta-analysis Dec 2019
- Blood vessels not helped by small vitamin D doses – meta-analysis Dec 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
- Low-dose vitamin D does not help cardiovascular (many were 100-1,000 IU) – meta-analysis June 2019
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Vitamin K (across all dose sizes and types) decrease Vascular Stiffness – meta-analysis - Dec 2018
- Small or infrequent doses of vitamin D do not reduce heart failure much – meta-analysis Jan 2018
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Peripheral Arterial Disease patients have low vitamin D levels – meta-analysis Oct 2015
- C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019
- Cardiovascular disease associated with postmenopausal non-human primates – meta-analysis Jan 2015
- Adding Calcium does NOT cause cardiovascular problems (reverses their meta-analysis) – Dec 2014
- Statin pain associated with 10 ng less vitamin D – meta-analysis Oct 2014
- Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis July 2014
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Cardiovascular disease 50 % more likely if low vitamin D - meta-analysis Nov 2012
- Omega-3 does not help heart patients – meta-analysis Sept 2012
- Half as many heart deaths for those with high levels of vitamin D – meta-analysis Sept 2012
- Shift workers 23 percent more likely to have cardiovascular events – meta-analysis July 2012
- Low density lipoprotein cholesterol is predictable from vitamin D levels – meta-analysis March 2012
- 800 IU Vitamin D does not help heart – meta-analysis Aug 2011
- Calcium without vitamin D increased heart risk by 30 percent - Jan 2011
- Meta-analysis unsure if vitamin D can prevent cardiovascular disease – Sept 2010
Omega-3 Helps (auto-updated)
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Synthetic EPA drug recommended to FDA for Cardio (Omega-3 is 8 X better) – Nov 2019
- Omega-3 reduces heart problems by ~5 percent – meta-analysis by Heart Association Oct 2019
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Few people have enough EPA (an Omega-3) to reduce heart failures – July 2019
- Another Nail in the Coffin for Fish Oil Supplements (nope) – JAMA April 2018
- Omega-3 provides many cardiovascular benefits – April 2018
- Omega-3 helps the heart, AHA class II recommendation, more than 1 gm may be needed – March 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Perhaps the Omega-3 optimal level is 10 percent, not 8 – Feb 2018
- Omega-3 Cardiovascular meta-analysis has at least 5 major problems – Jan 2018
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
- High dose Omega-3 probably reduces heart problems – American Heart Association – March 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Omega-3 – need more than 1 gram for a short time to reduce Cardiovascular Disease – Nov 2016
- Omega-3 is vital for health, mail-in test is low cost and accurate
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014
- Omega-7 - in addition to Omega-3
- Omega-3 reduces Coronary Heart Disease - infographic June 2014
- Cardiovascular diseases – conflicting data on benefits of Omega-3 and vitamin D – Feb 2014
- Cardiovascular system benefits from both Omega-3 and vitamin D – Dec 2012
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- Omega-3 does not help heart patients – meta-analysis Sept 2012
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Download the PDF from VitaminDWiki
Background: Systemic effects of long-term narrowband ultraviolet B (NB-UVB) phototherapy have not been well studied in vitiligo patients. An 11-year nationwide population-based retrospective cohort study was conducted using the Korean National Health Insurance claims database (2007-2017).
Objectives: To investigate the effects of long-term NB-UVB phototherapy on the risk of cardiovascular and cerebrovascular events in vitiligo patients.
Methods: This study included vitiligo patients with >100 phototherapy sessions (phototherapy group, n = 3,229) and <3 phototherapy sessions (no phototherapy group, n = 9,687), in which covariables with age, sex, insurance type, and comorbidities such as diabetes, hypertension, and hyperlipidemia were matched by 1:3 propensity score matching. The outcomes of interest were cardiovascular (ischemic heart disease and myocardial infarction) and cerebrovascular events (cerebrovascular infraction and hemorrhage). Cox proportional hazards models were used to assess the associations between NB-UVB phototherapy and each event.
Results: The risk of cardiovascular or cerebrovascular events was significantly decreased in the phototherapy group compared with the no phototherapy group (hazard ratio HR 0.637, 95% confidence interval CI 0.523-0.776). Subgroup analysis revealed that the risk of cardiovascular (HR 0.682, 95% CI 0.495-0.940) and cerebrovascular events (HR 0.601, 95% CI 0.470-0.769) were significantly lower in the phototherapy group than the no phototherapy group, respectively.
Conclusions: Our findings suggest that long-term NB-UVB phototherapy could decrease the risk of cardiovascular and cerebrovascular events in patients with vitiligo.
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