Both Cardiovascular and Cerebrovascular Events are Decreased Following Long-term NB- UVB Phototherapy in Patients with Vitiligo: A Propensity-score Matching Analysis
Journal of the European Academy of Dermatology and Venereology doi: 10.1111/jdv.16830
Jung Min Bae, MD, PhD,1* Yoon-Seob Kim, MD,2* Eun Ho Choo, MD,3 Mi-Yeon Kim MD,4 Jun Young Lee, MD, PhD,5 Hyung-Ok Kim, MD, PhD,6 and Young Min Park, MD, PhD.5
This study is based on 3,000 Koreans following 10 years of UVB treatment
- Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis March 2016
- Spotty skin coloring (vitiligo) treated by augmenting topical tacrolimus with oral Vitamin D – Oct 2016
- Vitiligo (loss of skin pigment) treated by narrowband UVB
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
Items in both categories Vitamin D Receptor and UV are listed here:
- Vitamin D genes and UVB vary massively across the Eastern Hemisphere – March 2020
- Vitamin D Receptor in vitiligo skin activated by UVB – May 2018
- UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017
- Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010
Items in both categories Skin and UV are listed here:
- UVB phototherapy (which increases Vitamin D and VDR) decreased risk of many heart and stroke problems – July 2020
- Sunscreen (SPF-30) slightly increased the vitamin D from UVB – RCT Jan 2019
- Vitamin D Receptor in vitiligo skin activated by UVB – May 2018
- Ultraviolet light (which produces vitamin D) decreased the use of psoriasis drugs for a year – Aug 2017
- Sunburning reduced by 200,000 IU of Vitamin D – RCT April 2017
- Phototherapy and vitamin D – Sept 2016
- Many other anti-cancer photoproducts generated on the skin in addition to vitamin D – Jan 2014
- UVB increases vitamin D even if poor kidney by changing CYP27B1 genes in skin – Dec 2013
- Vitiligo (loss of skin pigment) treated by narrowband UVB
- Eczema not reduced in small study which used narrowband UVB to raise vitamin D levels – Feb 2014
- Dermatologists view of UV radiation and the Skin – June 2013
- Intense UV damages cadaver skin– Oct 2012
- Possible DNA damage of skin if vitamin D levels less than 20 nanograms – April 2012
- For small amounts of sunshine the amount of skin exposed may not matter – Jan 2011
- Overview Skin and vitamin D
Items in both categories Cardiovascular and UV are listed here:
Items in both categories Stroke and Vitamin D Receptor are listed here:
- Resveratrol improves health (Vitamin D receptor, etc.)
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
- Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Download the PDF from VitaminDWiki
Background: Systemic effects of long-term narrowband ultraviolet B (NB-UVB) phototherapy have not been well studied in vitiligo patients. An 11-year nationwide population-based retrospective cohort study was conducted using the Korean National Health Insurance claims database (2007-2017).
Objectives: To investigate the effects of long-term NB-UVB phototherapy on the risk of cardiovascular and cerebrovascular events in vitiligo patients.
Methods: This study included vitiligo patients with >100 phototherapy sessions (phototherapy group, n = 3,229) and <3 phototherapy sessions (no phototherapy group, n = 9,687), in which covariables with age, sex, insurance type, and comorbidities such as diabetes, hypertension, and hyperlipidemia were matched by 1:3 propensity score matching. The outcomes of interest were cardiovascular (ischemic heart disease and myocardial infarction) and cerebrovascular events (cerebrovascular infraction and hemorrhage). Cox proportional hazards models were used to assess the associations between NB-UVB phototherapy and each event.
Results: The risk of cardiovascular or cerebrovascular events was significantly decreased in the phototherapy group compared with the no phototherapy group (hazard ratio HR 0.637, 95% confidence interval CI 0.523-0.776). Subgroup analysis revealed that the risk of cardiovascular (HR 0.682, 95% CI 0.495-0.940) and cerebrovascular events (HR 0.601, 95% CI 0.470-0.769) were significantly lower in the phototherapy group than the no phototherapy group, respectively.
Conclusions: Our findings suggest that long-term NB-UVB phototherapy could decrease the risk of cardiovascular and cerebrovascular events in patients with vitiligo.
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