Association Between Vitamin D Receptor Polymorphisms and Susceptibility to Parkinson's Disease: An Updated Meta-Analysis
Neurosci Letters, 720, 134778 2020 Jan 21, DOI: 10.1016/j.neulet.2020.134778
Jinzhao Gao 1, Jijun Teng 1, Zongchao Liu 1, Min Cai 1, Anmu Xie 2
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Pages listed in BOTH the categories Parkenson's and Vitamin D Receptor:
- Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
- Parkinson’s Disease 3 X more likely if a poor Vitamin D Receptor – May – 2022
- Parkinson’s Disease might be fought by Vitamin D and the activation of the Vitamin D Receptor – March 2022
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Parkinson's disease cognitive decline associated with poor Vitamin D receptor – Nov 2016
- Parkinson’s risk increased 2 to 7 times depending on Vitamin D Receptor – Sept 2016
- Parkinson's Disease associations with Vitamin D Receptor and GC gene – June 2016
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
Pages listed in BOTH the categories Parkenson's and Meta-analysis:
- Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020
- Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019
- Parkinson’s patients 50X less likely to get even a little sun– meta-analysis Jan 2019
- Parkinson's Disease 2.1 X more likely if low Vitamin D – Meta-analysis Nov 2018
- Parkinson’s Disease systematic review finds association with low vitamin D – Jan 2016
- 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Parkinson’s Disease – no association found with changes in Vitamin D genes – meta-analysis June 2014
- Parkinson’s disease 2X more likely if low Vitamin D – meta-analysis May 2014
- Parkinson’s Disease and the “Sunshine” Vitamin (vitamin D) – July 2013
- Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013
- Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012
The relationships between vitamin D receptor (VDR) gene polymorphisms, particularly ApaI, BsmI, FokI, and TaqI, and Parkinson's disease (PD) has received increasing attention in the research community. However, as the results yielded by this increased research have hitherto conflicted, we performed an updated meta-analysis of reports on the relationships between VDR polymorphisms and PD published before October 2019 that we collected from the PUBMED, EMBASE, EBSCO, China National Knowledge Infrastructure (CNKI), and Wanfang databases. The ten articles that met our screening criteria included 2782 patients and 3194 healthy controls. All the data that we received were analyzed with Stata 12.0 statistical software. The odds ratio (OR) and 95 % confidence intervals (CIs) were used to determine the relationship between VDR gene diversity and PD. While we did not find a significant correlation between the ApaI, BsmI, and TaqI polymorphisms and the risk of PD in any of the considered genetic models, we found a clear association between the
FokI polymorphism and susceptibility to PD (
- C vs. T: OR = 1.246, 95 % CI: 1.101-1.411, P = 0;
- CC vs. TT: OR = 1.630, 95 % CI: 1.243-2.139, P = 0;
- CT vs. TT: OR = 1.382, 95 % CI: 1.059-1.804, P = 0.017;
- CC + CT vs. TT: OR = 1.491, 95 % CI: 1.159-1.919,P = 0.002;
- CC vs. CT + TT: OR = 1.261, 95 % CI: 1.062-1.496, P = 0.008).
Our subgroup analysis performed according to ethnicity revealed that FokI increased the risk of PD in Asian populations (
- C vs. T: OR = 1.261, 95 % CI: 1.080-1.472, P = 0.003;
- CC vs. TT: OR = 1.664, 95 % CI: 1.189-2.330, P = 0.003;
- CT vs.TT: OR = 1.387, 95 % CI: 1.000-1.925, P = 0.05;
- CC + CT vs. TT: OR = 1.497, 95 % CI: 1.098-2.042, P = 0.011;
- CC vs. CT + TT: OR = 1.285, 95 % CI: 1.036-1.593, P = 0.022).
Overall, the gene polymorphism of FokI only increases the risk of PD among Asian populations. Given the limited sample size of this study, the findings should be carefully explained.