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Overview Tuberculosis and Vitamin D

TB has been increasing
TB global incidence
There are many indications that vitamin D can both PREVENT and TREAT TB

  • As with many other diseases, VitaminDWiki expects that there will be a at least a 4X range of vitamin D due to:
    • 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
  • Also expect that co-factors will prove to be very important
  • UV appears to be as powerful or perhaps more powerful than vitamin D at TREATING TB

See also VitaminDWiki

Chart by Wagner and Hollis,  downloaded from Grassroots April 2010 – video expected June
Items in both categories TB and Intervention are listed here:


Pages listed in BOTH of the categoriesTB and Genetics


See also web


A. Martineau: TB and Vitamin D

  • Search VitaminDWiki for Martineau 229 items as of July 2017
  • The role of vitamin D in tuberculosis pathogenesis and treatment April 2014
    A. Martineau, presented at 16th International Congress on Infectious Diseases - abstract-only online
    32% of people are infected with TB
    Vitamin D was used to treat TB in the pre-antibiotic era, and its active metabolite,
    1,25-dihydoxyvitamin D, has long been known to enhance the immune response to mycobacteria in vitro.
    Vitamin D deficiency is common in patients with active TB,
  • A. Martineau organized the Vitamin D conference in England - April 23-25 2014
  • Vitamin D and tuberculosis: more effective in prevention than treatment?
    Int J Tuberc Lung Dis. 2015 Aug;19(8):876-7. doi: 10.5588/ijtld.15.0506.
    Davies PD1, Martineau AR2. text not available for 6 months (Jan 2016)

TB arrested by cod-liver oil (containing vitamin D) in 1848 was 3X better than other treatments at the time

CLICK HERE if registered (free) for updated analysis of the 1848 study


Vitamin D Receptor ApaI Gene Polymorphism and Tuberculosis Susceptibility: A Meta-Analysis (Feb 2014)

Genet Test Mol Biomarkers. 2014 Feb 26.
Areeshi MY1, Mandal RK, Panda AK, Haque S.

Aim: Vitamin D performs its actions through the vitamin D receptor (VDR), which acts as a transcriptional factor. Many case-control studies have been performed in the past to elucidate the association of the ApaI polymorphism of VDR gene and the risk of tuberculosis (TB). However, these studies have shown inconsistent and conflicting results. In the present study, a meta-analysis was performed to investigate the potential relationship between the VDR ApaI gene polymorphism and the risk of TB.

Methodology: A quantitative synthesis was performed for the published studies based on the association between the VDR ApaI gene polymorphism and the risk of TB retrieved from PubMed (Medline) and EMBASE web databases. A meta-analysis was performed, and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all the genetic models.

Results: We observed a decreased risk of TB in allelic contrast (a vs. A: p=0.009; OR=0.869, 95% CI=0.782 to 0.965), homozygous (aa vs. AA: p=0.006; OR=0.724, 95% CI=0.575 to 0.910), and heterozygous (aA vs. AA: p=0.698; OR=0.948, 95% CI=0.722 to 1.243) comparisons. Similarly, dominant (aa+Aa vs. AA: p=0.032; OR=0.842, 95% CI=0.720 to 0.985) and recessive (aa vs. AA+Aa: p=0.027; OR=0.796, 95% CI=0.650 to 0.975) models also demonstrated a decreased risk of TB, whereas a heterozygous genotype (Aa vs. AA: p=0.109; OR=0.873, 95% CI=0.740 to 1.030) did not indicate any association with the risk of TB. There was no evidence of publication bias and heterogeneity test.

Conclusions: This meta-analysis suggests that ApaI polymorphism of the VDR gene is significantly associated with a decreased risk of TB. However, future larger studies with groups of populations are warranted to analyze this association.
PMID: 24571812


TB Day review by Vitamin D Council March 2014

Has the following infographic
Image


TB Review at Vitamin D Council May 2014

  • 1 in 3 people have latent TB
  • 1 in 10 people with latent TB get TB (1 in 30 overall)
  • More vitamin D has been associated with both prevention and treatment of TB,
    Just as the sun has been long associated with TB prevention and treatment

TB, Vitamin D and lipid metabolism (June 2014)

Cutting Edge: Vitamin D Regulates Lipid Metabolism in Mycobacterium tuberculosis Infection.
J Immunol. 2014 Jun 4. pii: 1400736. Epub ahead of print
Salamon H1, Bruiners N2, Lakehal K2, Shi L3, Ravi J2, Yamaguchi KD1, Pine R4, Gennaro ML4.

Vitamin D has long been linked to resistance to tuberculosis, an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces macrophage antimicrobial functions against Mycobacterium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated transcriptome and mechanistic studies. Transcriptome analysis revealed an association between vitamin D receptor (VDR) and lipid metabolism in human tuberculosis and infected macrophages. Vitamin D treatment of infected macrophages abrogated infection-induced accumulation of lipid droplets, which are required for intracellular M. tuberculosis growth. Additional transcriptomics results showed that vitamin D downregulates the proadipogenic peroxisome proliferator-activated receptor γ (PPARγ) in infected macrophages. PPARγ agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARγ signaling in regulating both vitamin D functions. These findings suggest the potential for host-based, adjunct antituberculosis therapy targeting lipid metabolism.
Copyright © 2014 by The American Association of Immunologists, Inc.
PMID: 24899504

Tuberculosis & Interleukin-32 – patent applied for – Aug 2014

Tuberculosis is controlled by Interleukin-32 when it has enough Vitamin D – patent applied for – Aug 2014


Vitamin D, cod liver oil, sunshine, and phototherapy: Safe, effective and forgotten tools for treating and curing TB -March 2018

Vitamin D, cod liver oil, sunshine, and phototherapy: Safe, effective and forgotten tools for treating and curing tuberculosis infections - A comprehensive review.
J Steroid Biochem Mol Biol. 2018 Mar;177:21-29. doi: 10.1016/j.jsbmb.2017.07.027. Epub 2017 Jul 26.
PDF is available free at Sci-Hub  10.1016/j.jsbmb.2017.07.027

McCullough PJ1, Lehrer DS2.
1 Summit Behavioral Healthcare, Ohio Department of Mental Health and Addiction Services, Cincinnati, OH, 45237, USA; Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, 45435, USA. Electronic address: patrick.mccullough at mha.ohio.gov.
2 Summit Behavioral Healthcare, Ohio Department of Mental Health and Addiction Services, Cincinnati, OH, 45237, USA; Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton, OH, 45435, USA.

Tuberculosis remains an epidemic throughout the world, with over 2 billion people, or more than one third of the world's population, infected with TB. In 2015, there were an estimated 10.4 million new cases of tuberculosis, and 1.8 million deaths, making TB one of the top ten causes of death worldwide. Approximately 95% of new TB cases occur in developing countries, where the costs of treatment force many patients and their families into poverty. The United Nations and the World Health Organization are working to end this global epidemic.
Historically,

  • cod liver oil in the 1840's,
  • phototherapy in the 1890's,
  • sunshine in the 1890's and 1930's,
  • oral vitamin D in doses of 100,000-150,000 international units a day the 1940's, and
  • injectable vitamin D in the 1940's

were all shown to be able to safely treat tuberculosis.
However, for reasons that are unclear, these treatments are no longer being used to treat tuberculosis. We will review several reports that documented the clinical efficacy of these seemingly disparate treatments in treating tuberculosis. Taken together, however, these reports show the consistent efficacy of vitamin D in treating tuberculosis infections, regardless of whether the vitamin D was produced in the skin from the effects of phototherapy or sunshine, taken orally as a pill or in cod-liver oil, or put into solution and injected directly into the body. We will discuss how vitamin D, through its action as a steroid hormone that regulates gene transcription in cells and tissues throughout the body, enables the body to eradicate TB by stimulating the formation of a natural antibiotic in white blood cells, the mechanism of which was discovered in 2006. We will speculate as to why vitamin D, cod liver oil, sunshine, and phototherapy are no longer being used to treat tuberculosis, in spite of their proven efficacy in safely treating this disease dating back to the early 1800's. In fact, in 1903 the Nobel Prize in Medicine or Physiology was awarded to a physician who was able to cure hundreds of cases of long-standing lupus vulgaris (cutaneous TB) with refracted light rays from an electric arc lamp. Vitamin D, cod liver oil, sunshine, and phototherapy have never been shown to lose their ability to safely eradicate tuberculosis infections, and deserve consideration to be re-examined as first-line treatments for tuberculosis. These treatments have the potential to help cost-effectively and safely end the global TB epidemic.

Overview Tuberculosis and Vitamin D        

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3731 TB Vitamin D Council.jpg admin 25 Mar, 2014 12:08 99.72 Kb 3728
3608 Bsml decreases TB.pdf PDF 2013 admin 08 Feb, 2014 14:31 620.12 Kb 1552
3575 TB Dec 2013.pdf PDF - 2013 admin 24 Jan, 2014 02:18 469.10 Kb 1820
2368 TB 28 year.pdf PDF admin 14 Apr, 2013 15:38 380.17 Kb 1734
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