Consolidated COVID-19 Coronavirus Report From Investigative Health Journalist Bill Sardi

Must go to his site to see it - He had me remove the page from VitaminDWiki because he needs the advertising income
Note only 347 people had viewed this page as of May 23

---

COVID-19 treated by Vitamin D - studies, reports, videos (VitaminDWiki)

Intervention Clinical Trials

• Vitamin D Testing and Treatment for COVID 19 Study completion May 2021
  • Supplement with 10,000 IU daily and unrealistically expect COVID-19 improvement in only 2 weeks (also look at 4 and 6 weeks)
• Dr. Manson is planning a COVID-90 Vitamin D RCT for both prevention and treatment Medscape Video May 11
  • In her video she recommends up to 2,000 IU of Vitamin D daily
• VitaminDWiki is funding a Randomized Controlled Clinical Trial in Sri Lanka which may start in early June
  • 400,000 IU of Vitamin D vs placebo to 1,000 people entering quarantine centers for 14 days
  • See also Vitamin D trial with COVID-19 in Sri Lanka - interview May 16
• No trials have results of COVID-19 being prevented or treated by Vitamin D (but many are underway) May 1, 2020
  • "Vitamin D: A rapid review of the evidence for treatment or prevention in COVID-19"
• First RCT for Vitamin D and COVID-19 outside of China with enough Vitamin D - announced April 14
  • Using 400,000 IU of Vitamin D in France for those >age 70 recently tested positive for COVID-19
  • Dr. ANNWEILER had recently developed a way to estimate Vitamin D levels (only in the elderly) without a test
    • Is a senior Vitamin D insufficient - a 2 minute questionnaire is 85 percent accurate – Nov 2019
• Spanish RCT using 25,000 IU probably not enough to make a difference
• COVID-19 association with Vitamin D also being explored by Hollis and Wagner - April 2020
• 2,000 IU of vitamin D and 15 mg of Zinc twice daily for 60 days Clinical Trial
  • Seniors who already have tested positive for COVID-19.
  • That small of a dose of vitamin D will be unlikely to show any benefit during the trial.
• Use 10,000 IU then 5,000 IU every few days to treat COVID-19 induced SARD Spain, April 30
  • That small of a dose of vitamin D will be unlikely to show any benefit that late into the infection

Observation Clinical Trials

• Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women posted May 29
  • Exclusion Criteria: No vitamin D , Vitamin B12 or Zinc supplement use
• Clinical trial Arm1: Observe COVID-19 Deaths and Vitamin D levels in the UK trial completion June 2021
  • Arm2: Measure Vitamin D of patients in general practices and see if they get COVID-19 in the next 6 months (prevention)
• Clinical trial obeserving Vitamin D levels of 500 people in Spain at entry into ICU and recording outcomes analysis to be completed July 2020
• Clinical trial to observe vitamin D levels of 100 COVID-19 Turks in hospital to be completed July 2020
  • Bursa City Hospital, NCT04394390
• WHO 3 RCT for Vitamin D and COVID-19 as of May 27 (WHO not responding when asked for details)
  • NCT04386044 Investigating the Role of Vitamin D in the Morbidity of COVID-19 Patients 10/05/2020
  • NCT04334005 Vitamin D on Prevention and Treatment of COVID-19 29/03/2020
  • ChiCTR2000029732 Impact of vitamin D deficiency on prognosis of patients with novel coronavirus pneumonia (COVID-19) 2020-02-10
• Clinical trial to measure Vitamin D status AND vitamin D genes of COVID-19 patients in Portugal Study completion date March 2021
  • No intervention, hope they consider genes not noticed by Vit. D tests: such as Vitamin D Receptor, CYP27B1

Vitamin D Dosing Recommendations for COVID-19

• Perspective: improving vitamin D status in the management of COVID-19 May 22 free PDF
  • If low: 50,000 IU twice a week at the diagnosis (100,000 IU total)., then 50,000 IU taken once a week for the 2nd and 3rd weeks.
    • Note: VitaminDWiki believes that this dosing is not large enough for prevention, much less treatment
• COVID-19 might be prevented in 2 months by 50,000 IU weekly – May 12, 2020
• for people who have not been taking any vitamin D BusinessWorld May 22 - by Dr Renu Mahtani in videos below
  • Vitamin D 60k IU twice a week for two weeks to be followed by 60k once a week for the next six weeks.
  • or Vitamin D 60k IU daily for three days to be followed by 60k weekly for the total period of two months.
  • Thus 480,000 IU total, No Vitamin D testing needed

COVID-19 associated with Low Vitamin D

• Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes Preprint May 6 FREE PDF
• Vitamin D for Covid-19? May 12 FREE PDF
• Association of Vitamin D Deficiency and Treatment with COVID-19 Incidence preprint May 13, FREE PDF
• Perspective: improving vitamin D status in the management of COVID-19 European Journal of Clinical Nutrition May 12 FREE PDF
• Avoidance of vitamin D deficiency to slow the COVID-19 pandemic Martin Kohlmeier, BMJ, May 20 FREE PDF
• COVID-19 and vitamin D—Is there a link and an opportunity for intervention? Hrvoje Jakova, letter to the editor, May 1, FREE PDF
• No COVID-19 patient in ICU had >20 ng, 4 had 12.5-20 ng, 13 had < 12.ng preprint May 22
• COVID-19 associated with low Vitamin D in more than 20 studies – May 21, 2020 BMJ reply
• Max Minute: How Much Does Vitamin D Help Against COVID-19? CBS News NYC Video May 19
• The Essential Role of Vitamin D in the Biosynthesis of Endogenous Antimicrobial Peptides May Explain Why Deficiency Increases Mortality Risk in COVID-19 Infections preprint May 16 (at least 10,000 IU daily)
• Low Vitamin D increased chance of COVID-19, unless supplement – May 13, 2020
  • Suspect that an RCT would find even more benefit
  • 
• Vitamin D appears to play role in COVID-19 mortality rates Northwestern Univ. May 7
  • "Patients with severe deficiency are twice as likely to experience severe complications, including death"
  • "...statistical analysis of data from hospitals and clinics across China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the United Kingdom (UK) and the United States."
• There are 2 concurrent pandemics – COVID-19 and Vitamin D deficiency – May 13, 2020
• Vitamin D Deficiency and ARDS after SARS-CoV-2 Infection Irish Medical Journal May 11
  • Analysis of 36 COVID-19 patients: Vitamin D status: (nmol) ARDS 27, pneumonia 41;
  • and, if <30 nmol. 3.2 X more likely to have intubation

Vitamin D levels are lower in those who test positive for COVID-19 - Nutrients May 09

• 
• Vitamin D Level Is Directly Correlated to COVID-19 Outcome Mercola May 8
  • Overview of many studies and video by Ivor Cummins
• Vitamin D linked to low virus death rate in 20 countries in Europe Science Daily May 7
• Evidence Supports a Causal Model for Vitamin D in COVID-19 Outcomes May 6 preprint
  • Excellent extensive use of Causal Influence AI to discover associations.
  • I have suspected that Causal Influence could be much better, far lower cost, and faster than the use of RCTs
• Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 deaths preprint May 7
  • "permanent unit increase in UVI is associated with a 2.2 % decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01]
  • as well as a 1.9 % decline in the daily growth rates of CFR [p < 0.05]
  • 64 countries, 78 days, 6 UVI models
• Vitamin D Level of Mild and Severe Elderly Cases of COVID-19: A Preliminary Report May 5
  • 176 seniors in S. Asia - published in India
  • 
• Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics preprint May 5
  • 186 patients. Lower Vitamin D levels associated with worse COVID-19 only for males
  • 
• Almost everyone with COVID-19 in a Louisiana ICU had low vitamin D – April 29, 2020
• COVID-19 mortality rate highest North of 35 degrees latitude (Vitamin D) – April 20, 2020
• Critical COVID-19 was 19X more likely if low vitamin D – April 15, 2020 Philippines
• Research Suggests a Link Between Vitamin D Deficiency and COVID-19 Deaths May 5
  • Indonesia preprint 13X if vitamin D insufficient,19X for patients who are vitamin D deficient.
• COVID-19 infections associated with very low vitamin D – Turin Italy – March 2020

Speculation

• Reduced COVID-19 in Mexico is associated with higher UV or higher elevation (both of which are associated with higher vitamin D) preprint May 27
  • 
  • 
• Vitamin-D and COVID-19: Do Deficient Risk a Poorer Outcome? Lancet May 20
  • Reviews many reports and includes the following comment by a researcher of "COVIDENCE UK, a study to investigate how diet and lifestyle factors might influence transmission of SARS-CoV-2, severity of COVID-19 symptoms, speed of recovery, and any long-term effect"
  • "Despite his enthusiasm for the study, Martineau is pragmatic: “At best vitamin D deficiency will only be one of many factors involved in determining outcome of COVID-19, but it’s a problem that could be corrected safely and cheaply; there is no downside to speak of, and good reason to think there might be a benefit”.
• Should be cost-effective to use Vitamin D, Vitamin C and Curcumin to fight Covid-19 in India preprint May 22
  • Fails to mention dose sizes or frequencies
• U.S. Rep. Glenn Grothman (Wisc.) wants the CDC to investigate if Vitamin D can fight COVID-19 May 22
• Letter: does vitamin D have a potential role against COVID-19 May 20
  • 
• Optimisation of Vitamin D Status for Enhanced Immuno-protection Against Covid-19 Irish Medical Journal, April 2020
• Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment Aug 2020
  • both should help fight lung problems. Clinical Trials needed to see to discover dosing and benefits FREE PDF
• Mechanism of inflammatory response in associated comorbidities in COVID-19 PubMed literature Review May 12, free PDF
  • "Vitamin D is highlighted as a potential therapeutic target, because in addition to acting on the immune system, it plays an important role in the control of cardiometabolic diseases"
• Vitamin D: A Low-Hanging Fruit in COVID-19? Medscape May 17
  • Statements by a dozen doctors, such as Dr. Rosen: "I've been a huge skeptic from the get-go, and loudly criticized the data for doing nothing. I am surprised at myself for saying there might be some effect,"
• DOES VITAMIN D DEFICIENCY REALLY INCREASE RISK OF DEATH FROM COVID-19? Newsweek May 15
  • Reviews about 10% of the items on this page
• Which fights COVID-19 more in the long-term - Vitamin D or Ultraviolet light Elemental+ May 13
  • Note: Megadoses of Vitamin D can restore the immune system in days, whereas UV takes months
• Vitamin D and SARS-CoV-2 virus (Vitamin D should help) British Medical Journal May 13, 2020
  • Unfortunately. the UK consensus is that 400 IU is enough to prevent or treat any health problem, including COVID-19
• The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients preprint April 30
  • FoxNews May 7: China, France, Germany, Italy, Iran, South Korea, Spain, Switzerland, the UK and the US.
  • Also reported on in Science Blogs
  • "Backman said this correlation might help explain the many mysteries surrounding COVID-19, such as why children are less likely to die. Children do not yet have a fully developed acquired immune system, which is the immune system’s second line of defense and more likely to overreact. Children primarily rely on their innate immune system,” Backman said. “This may explain why their mortality rate is lower.”
  • "Not only does vitamin D enhance our innate immune systems, it also prevents our immune systems from becoming dangerously overactive"
• Role of vitamin D in pathogenesis and severity of COVID-19 infection preprint April 20
  • Includes ACE2 discussion
• 
• Perhaps solve the other pandemic: Vitamin D deficiency — to help beat Coronavirus? April 9, Joanneova - Australia 258 comments 10 days later
• Vitamin D reduces viral respiratory infections – editorial April 18, 2020 in VitaminDWiki
• Taiwan seniors have high vitamin D levels, perhaps that reduces the risk of COVID-19 outbreaks von Helden April 18
• Does Vitamin D Protect Us From Viral Infections? April 6
  • Croatian, 17 references - probably does protect
• Deficient Vitamin D status might be a severe risk factor for COVID-19 DailyKos April 9
• The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality April 8
  • Charts of country levels of vitamin D and COIVD-19 cases and mortality Published May 6
  • Chart by von Helden No high death rates if Vitamin D> 30 ng / ml. (Mortality> 0.1 dead / 1000 inhabitants)
• 
• COVID-19: Vitamin D deficiency; and, death rates; are both disproportionately higher in elderly Italians, Spanish, Swedish Somali, and African Americans? April 7
• Vitamin D may be a COVID-19 Game-changer - BMJ April 6, 2020
• Vitamins C and D being considered as Coronavirus Treatments - April 7, 2020
• Preventing a COVID-19 pandemic with Vitamin D – Grant April 2020)
• COVID-19 and Vitamin D: Could We Be Missing Something Simple? Children's Health Defence April 9
• COVID-19 prompts awareness of deficiencies of Vitamin D, C and Magnesium - April 6 2020
• Vitamin D Supplements Could Reduce Risk of Influenza and COVID-19 Infection and Death - April 9, 2020
• Vitamin D should prevent COVID-19 (recommended dose takes 3 months to raise levels) - April 2020
• 97 year old woman with hypertension, diabetes, heart problems but with 75 ng of Vitamin D survived COViD-19 von Helden April 10

Higher levels of vitamin D result in fewer COVID-19 problems

• COVID-19 might be fought by 2 doses of Vitamin D (200,000-300,000 IU each) – Feb 2020 peer-reviewed publication

VIDEOS

• Dr. Campbell (has daily COVID-19 videos) COVID-19 and Vitamin D May 9
• Dr. Coimbra: Vitamin D and COVID, 88 minutes in Portuguese May 1
  • Click here for transcript in many languages
• COVID-19 and Vitamin D 30 minute updated May 12, excellent, Renu Mahtani
  • previous version, taken down by YouTube, had 600,000 views, >2,000 comments
  • for people who have not been taking any vitamin D she recommends Business World May 22
    • Vitamin D 60k IU twice a week for two weeks to be followed by 60k once a week for the next six weeks.
    • or Vitamin D 60k IU daily for three days to be followed by 60k weekly for the total period of two months.
• Could Vitamin D Help with COVID-19 April 9 India
• Vitamin D against Viral Infections: Antiviral Nutrition 2020 (excerpt 3) by Dr. Alex Vasquez March 6, 8 minutes
• Vitamin D for respiratory infections April 18 Rishi Desai CDC Viral Infections
• Could Vitamin D Help with COVID-19? April 6
• Vitamin D and Immunity, Lots of Evidence April 15 Dr. Campbell
• Vitamin D normalizes the ACE2, which is the attachment point for COVID-19 virus Dr. Patrick Video April 12
  • Her video reviews about a dozen publications. Her description of the importance of vitamin D starts at 24:52
• Many videos by Sunil Wimalawansa April 12-- - , 5-10 minutes each
  • He is starting a Randomized Controlled Trial in Sri Lanka for COVID-19 treatment by Vitamin D - not described in the videos
  • 20: Vitamin D & COVID-19
  • 21: How does vitamin D reduce COVID-19 infection?
  • 22: What is ACE2 receptor, through which COVID-19 enters cells
  • 23: How does COVID-19 kill us?
  • 26: How does vitamin D reduce COVID-19 infection
  • 44: What have we learned during the past 2 weeks on COVID-19?
  • 45: How vitamin D help to attenuate COVID-19?
  • 48: Herd immunity and the importance of testing
  • 53 Reducing the severity of COVID-19 with vitamin D adequacy
  • 54: Tropical countries, warm weathwer, and lower deaths due to COVID-19
• Dr. Eric Berg DC April 5 - one of his many vitamin D videos
• Take 100,000 IU of vitamin D, and again 3 months later to prevent COVID-19 Dr. Anderson March 22

---

Search Google Scholar for "COVID-19" "Vitamin D"
2510 publications as of May 16, 2020
Short URL for this section = is.gd/COVIDMedia

---

25 most-recently changed VIRUS pages (Coronavirus)

---

See also in VitaminDWiki

• Zinc and Vitamin D category listing has 42 items along with related searches
• Resveratrol category listing has 10 items along with related searches

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Resveratrol improves health (Vitamin D receptor, etc.) has the following

• The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
• Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
• Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
• Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
  • Quercetin and Curcumin in the case of Resveratro

The articles in both of the categories Resveratrol and Vitamin D Receptor