Genetic Testing and Molecular Biomarkers – Nov 2012
Rui-Fen Sun,2,* Qun-Hui Li,1 Da-Xing Wang,1 Feng Zhao,1 Jun-Min Li,1 Qi Pu,1 Zhong-Zi Zhang,1 Yan Jin,1 Bai-Lian Liu,1 and Ying Xiong1
1 Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, People's Republic of China.
2 Central Laboratory, Yunnan University of Chinese Traditional Medicine, Kunming, People's Republic of China.
Address correspondence to: Bai-Lian Liu, M.D.; Department of Orthopedics, Kunming Medical University. National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051
People's Republic of China, E-mail: 1628322036 at qq.com
Ying Xiong, M.D.; Department of Orthopedics, Kunming Medical University, National Clinical Key Specialty, Yanan Hospital, Kunming, Yunnan 650051, People's Republic of China. E-mail: xiongying789 at 126.com
Objective: Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and susceptibility to osteoporosis. Conflicting results, however, were obtained. The aim of this study was to evaluate the effect of VDR BsmI polymorphism on osteoporosis risk using a meta-analysis.
Methods: Twenty-six publications were identified by searching PubMed and Embase databases. The association between VDR BsmI polymorphism and osteoporosis was estimated by calculating pooled odds ratios (ORs) with corresponding 95% confidence intervals (Cis).
Results: The bb genotype was associated with a significantly decreased risk of osteoporosis in overall comparison (
- bb vs. BB: OR=0.61, 95% CI, 0.40–0.92;
- bb vs. BB/Bb: OR=0.70, 95% CI, 0.52–0.95, respectively).
Subgroup analyses showed that the bb genotype had a decreased risk of developing osteoporosis in
- postmenopausal women (bb vs. BB/Bb: OR=0.68, 95% CI, 0.46–0.98) and
- Africans (Bb/bb vs. BB: OR=0.18, 95% CI, 0.09–0.37).
Conclusion: The VDR BsmI polymorphism may have a protective role against the development of osteoporosis.
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PDFs of paper and supplemental data are at bottom of this web page
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Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) Magnesium Vitamin D in the blood
AND in the cells
3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells 13) Sulfroaphane and perhaps sulfur Vitamin D Receptor
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDRVitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012
7774 visitors, last modified 05 Dec, 2016,This page is in the following categories (# of items in each category)Skin - Dark 439 Osteoporosis 192 Genetics 281 Meta-analysis of Vitamin D 523 Vitamin D Receptor 410
ID Name Comment Uploaded Size Downloads 1761 BB supp_table2.pdf admin 30 Nov, 2012 16:02 27.13 Kb 1158 1760 Sup table 2.jpg admin 30 Nov, 2012 16:01 73.18 Kb 1331 1759 bb.jpg admin 30 Nov, 2012 16:01 61.98 Kb 1685 1758 BB supp_table1.pdf admin 30 Nov, 2012 16:01 30.54 Kb 1060 1757 Vitamin D genes and osteoporosis - Nov 2012.pdf admin 30 Nov, 2012 16:00 219.39 Kb 1906
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