Chapter 94 - Overview of Vitamin D Actions in Cancer
Vitamin D (Fourth Edition), Volume 2: Health, Disease and Therapeutics, 2018, Pages 711-742
https://doi.org/10.1016/B978-0-12-809963-6.00094-8
Throughout the last 2 or 3 decades it has become evident that vitamin D has effects beyond calcium and bone metabolism. A wide variety of cells and tissues are affected by vitamin D. These targets include tumor cells and the findings have led to a vast series of studies on the actions of vitamin D on cell growth regulation, treatment of cancer and development of potent synthetic vitamin D analogues as inhibitors of cancer cell growth. Various specialized chapters in this book will discuss in detail the effects of vitamin D on specific cancers. In this chapter our goal is to set the stage by providing an overview of the history and current state of knowledge of the field. We will address several areas: recent developments in studies of vitamin D and cancer, regulation of tumor cells, possible mechanisms, and clinical applications.
Cancer category starts with the following
- Cancer
197 items Overview Cancer and vitamin D - After Cancer Diagnosis
73 items - Bladder Cancer
21 items - Breast Cancer
209 items Overview Breast Cancer and Vitamin D - Colon Cancer
100 items Overview Cancer-Colon and vitamin D - Leukemia
14 items - Lung Cancer
44 items Overview Lung cancer and vitamin D - Lymphoma Cancer
20 items - Other Cancer
52 items - Prostate Cancer
85 items Prostate Cancer and Vitamin D studies - Pancreatic Cancer
52 items - Skin Cancer
103 items Overview Suntans melanoma and vitamin D - Evidence that Vitamin D prevents Cancer – Grant Feb 2018
- Cancer risk in older women reduced 32 percent by 2,000 IU of Vitamin D plus Calcium – 4 year RCT Oct 2016
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Risk of Cancer increased due to Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018
Vitamin D Receptor has the following types of Cancer as of March 2019
Risk Increase Cancer 4.6 Breast Cancer 16.9 X another study 3.1 Colon Cancer survival 2.7 Gastric Cancer 2.4 Lung Cancer 2 Melanoma Non-melanoma Skin Cancers 1.6 Prostate Cancer while black Download the PDF from Sci-Hub via VitaminDWiki
TABLE 94.1 Vitamin D Receptor in Tumors and Malignant Cell Types
Basal Cell Carcinoma
Breast Carcinoma
Bladder Cancer
Cervical Carcinoma
Colonic Adenocarcinoma
Colorectal Carcinoma
Gall Bladder Carcinoma
Glioblastoma
Kaposi Sarcoma
Lung Carcinoma
Lymphocytic Leukemia
Malignant B-Cell Progenitors
Malignant Melanoma
Medullary Thyroid Carcinoma
Myeloid Leukemia
Multiple Myeloma
Osteogenic Sarcoma
Ovarian Carcinoma
Neuroblastoma
Non-Hodgkin’s Lymphoma
Pancreatic Carcinoma
Parathyroid Adenoma
Pituitary Adenoma
Prostate Carcinoma
Renal cell Carcinoma
Squamous cell Carcinoma
Transitional cell Bladder Carcinoma
Uterine CarcinosarcomaTable of contents
Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
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