Overview Asthma and Vitamin D

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See VitaminDWiki

• VitaminDWiki pages containing ASTHMA in title (130 as of Aug 2021)
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 intervention
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on chart to see the study

Related pages in VitaminDWiki

• All items in Breathing and Vitamin D 402 items includes Asthma, Pneunomia, RTI, TB, Allergy, COPD
• All items in category Autoimmune and Vitamin D 178 items

20 Recent studies in Breathing and Intervention categories (give vitamin D and see what happens) in VitaminDWiki:

20 Recent studies in Breathing and non-daily Intervention in VitaminDWiki:

Breathing and Vitamin D Binding Protein:

Items in both VitaminDWiki categories of Breathing and Magnesium:

• Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021
• Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019
• Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019
• Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019
• Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
• Childhood asthma about 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Aug 2016
• 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
  • This list is NOT automatically updated

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See asthma and Vitamin D on the web

• There’s No ‘One Size Fits All’ Treatment for Asthma NYT Feb 2021 NYT PDF
  • A wide variety of triggers and treatments 56 page guidelines PDF The word VITAMIN does not occur once
• Asthmatics exhale better if higher level of Vitamin D - 2018
  Correlation between the vitamin D levels and asthma attacks in children: Evaluation of the effects of combination therapy of atomization inhalation of budesonide, albuterol and vitamin D supplementation on asthmatic patients.
  MEF25 = Maximal Expiratory Flow at 25% of Forced Vital Capacity
  
   Download the PDF from VitaminDWiki
• Clinical Trials 70 Vitamin D intervention trials for Asthma of Nov 2020, including
  • Adults 5,000 IU daily
  • Children: 50,000 IU loading + 10,000 IU daily
• Studies Suggest an Acetaminophen-Asthma Link NYT Dec 2011 - NOT vitamin D
  • The sharp worldwide increase in childhood asthma over the past 30 years has long perplexed researchers,
  • Doctors stopped giving aspirin to children with fevers, opting instead for acetaminophen. (Reyes - 1980's)
    • VitaminDWiki wonders if this association deals with world-wide, latitude, etc.
• International patent for vitamin D and analogs to prevent asthma
  • (WO2005079464) VITAMIN D RECEPTOR ANTAGONISTS AND THEIR USE IN TREATING ASTHMA
• Why are asthma rates higher among children now than in the past? Medical Expresss Nov 2012
  • Have given up on many previous hypothesis, and now considering vitamin D deficiency]
• Effects of vitamin D levels on asthma control and severity in pre-school children 2016
  • Ages 1-4, winter, free PDF online
  • 10 ng/ml in the asthma group and 15 ng/ml control group
• Vitamin d insufficiency and asthma severity in adults from Costa Rica Sept 2013

5X less likely to be hospitalized for Asthma if adequate vitamin D
 Download the PDF from VitaminDWiki

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Children born with higher vitamin D less likly to get asthma later - May 2021

The correlation between neonatal vitamin D levels and the risk of childhood asthma attacks
Transl Pediatr. 2021 Apr;10(4):914-920. doi: 10.21037/tp-21-92.
Wenlin Li 1, Jin Zhou 2, Shen Liu 2, Kaihui Xing 1, Ling Yang 1, Lihua Zhong 1, Qiuli Chen 2, Wei Zhang 1
 Download the PDF from VitaminDWiki

Background: To explore the correlation between neonatal vitamin D levels and the risk of asthma in children aged 3-9 years.

Methods: A total of 1,534 subjects were selected, and clinical and laboratory test data of all subjects were collected at birth, including 25-hydroxyvitamin D3 [25(OH)D3] levels, gender, season of birth, birth weight; whether delivery was premature, cesarean section, or primipara; and parental details including maternal age, ethnicity, level of education, history of smoking, and history of maternal or paternal asthma. The level of 25(OH)D3 was used as a continuous variable to analyze its correlation with the risk of asthma using the Cox proportional regression model. In addition, subjects were divided into four groups according to their 25(OH)D3 quartiles, and the first quantile group was used as a reference to analyze the risk of asthma in the other groups. Further subgroup analysis was conducted according to the patients' gender and birth season.

Results: Among the 1,534 subjects included, there were 107 cases in the asthma-affected group and 1,427 cases in the normal control group. Compared with the control group, the level of 25(OH)D3 in the asthma group was significantly lower (P=0.03), the mother's education level was lower (P=0.002), but the preterm birth rate, cesarean section rate, and parental asthma prevalence rate were significantly higher (all P<0.05). When the neonatal 25(OH)D3 was divided into quartiles to perform a categorical variable analysis, we found that compared with the first quantile (Q1, 0.0-25.1 mmol/L), the risk of asthma in Q4 was reduced by 50% (HR=0.50, 95% CI: 0.38-0.76). The second quantile group (Q2) and the third quantile group (Q3) showed no significant difference in the risk of disease compared with Q1 but showed a trend of decreasing risk as the quantile group increased (the trend P values were both <0.05). This correlation was still valid when a stratified analysis was made based on gender and birth season.

Conclusions: There is a significant correlation between a reduced vitamin D level in newborns and the subsequent risk of asthma in children aged 3-9 years. Moreover, the level of vitamin D is an independent risk factor for childhood asthma.

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The worse the asthma in children, the lower their vitamin D level - Feb 2019

Serum 25-hydroxy vitamin D in asthmatic children and its relation to disease severity
International Journal o fCommunity Medicine and Public Health, DOI: http://dx.doi.org/10.18203/2394-6040.ijcmph20185510
Ihab Hafez El Sawy, Passant Al-Said Moaz, Ghada Mohamed Farouk El Deriny, Mohamed Sami Abd El Moniem El Kholy

Background: Asthma is a chronic immunological disorder of the lungs. Vitamin D has several effects on the innate and adaptive immune systems. Little is known about vitamin D level and its impact on severity of asthma in children. This study aimed to determine vitamin D levels in asthmatics versus control children; studying the relation if any between these levels and asthma severity.

Methods: This cross-sectional study was conducted on 60 asthmatic children and 20 apparently healthy children as controls. Asthma patients were divided into 3 groups (mild, moderate, severe; 20 each). Asthma severity was based on GINA criteria. Vitamin D level was measured to all study group.

Results: The difference between the mean values of vitamin D level in control and asthmatic patients was statistically significant (p<0.001). This difference between control group and each asthma subgroup and between asthma subgroups versus each other were statistically significant being highest in control and lowest in patients with severe asthma (p<0.001). Differences in vitamin D status in control and all asthmatic patients were statistically significant (p<0.001). The difference between control group and each asthma subgroup according to vitamin D status were statistically significant (p<0.001). Concerning asthma subgroups the difference in vitamin D status between severe versus mild and moderate asthma were statistically significant (p<0.001), while between mild and moderate asthma it was not.

Conclusions: Significantly lower vitamin D level in asthmatic children compared to controls and a differential decrease in vitamin D levels in asthmatic children being lowest in severe asthma was confirmed.
 Download the PDF from VitaminDWiki

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Asthma Drug Therapy (nothing about Vitamin D)

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Asthma is the most common health problem in children, inhalers not used properly - March 2019

Using an Asthma Inhaler Correctly NYT

• "Asthma is the most common chronic disease of childhood, and using an asthma inhaler is often a first step toward medical autonomy for a child with asthma"
• "Once or twice a day, children may take what are called controller therapies, most often inhaled corticosteroids which decrease chronic inflammation in the lungs and make exacerbations less likely. And then, when they feel symptoms coming on, or find themselves in a situation where symptoms seem likely, they use what are called rescue medications, bronchodilators which relax the smooth muscle so that air can move through those tubes."
• "You have to take off the cap, shake the inhaler for three to five seconds and connect it to the spacer (a chamber between the inhaler and the patient’s mouth that holds the drug suspended and makes it easier to breathe it in). Then you are supposed to exhale completely, and put the mouthpiece or mask in or around your mouth correctly, forming a tight seal. Then you release the medication from the inhaler by pressing the canister down, breathe in slowly and deeply through the spacer (for spacers with a whistle, you do not want to hear the whistle), and hold your breath for 10 seconds. Finally, you exhale again — and then you wait a minute and repeat the process."
• "Eighty-four percent of the patients did not wait the 30 seconds that the researchers felt was the absolute minimum time between inhalations. More than 50 percent waited less than 15 seconds."

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Asthma reduced by Diet, Magnesium, Vitamin D, Tumeric, Breathing Exercises, Pine Bark, Vit B6

8 Proven Ways To Relieve Asthma Naturally GreenMed Info Jan 2019

• "Asthma affects about 300 million people worldwide.It is growing by 50 percent every decade and causes upwards of 180,000 deaths per year"
• "In a study of 1,531 children in Manitoba, Canada, researchers found that the risk of developing asthma by the age of seven was cut in half when the first diphtheria, pertussis, tetanus (DPT) immunization was delayed by more than two months. Delaying all three doses of DPT vaccines cut asthma risk by 60 percent."

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Asthma Factoids from The Body by Bill Bryson, 2019

• The U.K.:30 percent of children have shown asthma symptoms.
  • The lowest rates are in China, Greece, Georgia, Romania, and Russia, with just 3 percent.
• Pearce. “I have spent thirty years studying asthma, and the main thing I have achieved is to show that almost none of the things people think cause asthma actually do. They can provoke attacks if you have asthma already, but they don’t cause it. We have very little idea what the primary causes are. We can do nothing to prevent it.”
• with some asthmatics if you put their feet in a bucket of ice water, they begin to wheeze immediately. Now, that can’t be due to inflammation, because it happens too fast.
• Asthma is very different from other lung disorders in that it is normally present only some of the time.
• Even when there are no symptoms present, other diseases will nearly always be evident in blood or sputum tests. In asthma, in some cases, the disease just vanishes.”

Asthma worse during circadain rythem night - Sept 2021

Why Does Asthma Get Worse at Night?
Had been known for centuries, now a clinical trial documented the reason