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1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019

A complete physical mapping of the vitamin D receptor gene for dental implant loss: A pilot study.

Clin Oral Implants Res. 2019 Dec;30(12):1165-1178. doi: 10.1111/clr.13529
Munhoz Pereira T1, Alvim-Pereira F2, Kaiser Alvim-Pereira CC2, Ignácio SA1, Machado de Souza C1, Trevilatto PC1.

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OBJECTIVES:
The aim of this pilot case-control study was to investigate the association of clinical variables and genetic polymorphisms in the vitamin D receptor gene (VDR) with dental implant loss.

MATERIAL AND METHODS:
This study was carried out with 244 individuals with mean age 51.90 ± 11.28 (81 cases and 163 controls matched by age, sex, and smoking habit). Also, the clusterization phenomenon was investigated stratifying the sample into two groups: (a) 34 patients with multiple losses (presenting two or more lost implants) and (b) 210 without multiple losses (up to one implant loss). Sociodemographic, clinical, and periodontal parameters were analyzed. The tagSNPs in the VDR gene were analyzed by real-time PCR. Univariate and multivariate analyses were performed (p < .05).

RESULTS:
Edentulism, number of implants installed, and Gingival, Plaque, and Calculus Indexes were associated with implant loss in the univariate analysis. After the multivariate analysis, the allele G of rs3782905 in the recessive model, together with number of installed implants and Gingival Index, was associated with implant failure.

CONCLUSION:
It is suggested that the allele G of rs3782905 in the recessive model may be a new genetic risk marker for dental implant loss in patients who lost two or more dental implants. In addition, number of implants installed and Gingival Index were also associated. Replication is mandatory to confirm these findings, due to the modest sample size of this work.

Attached files

ID Name Comment Uploaded Size Downloads
13179 loss vdr.jpg admin 18 Dec, 2019 17:57 50.40 Kb 112
13178 Dental inplant loss VDR.pdf PDF 2019 admin 18 Dec, 2019 17:57 1.25 Mb 103
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