Toggle Health Problems and D

Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 2018

Postural Balance and Vitamin D Receptor Gene Polymorphism in Physically Independent Older Adults

International Conference on Applied Human Factors and Ergonomics. AHFE 2018:
Advances in Human Factors and Ergonomics in Healthcare and Medical Devices pp 397-404 |
Regina Poli-Frederico Marcos Fernandes Rubens A. da Silva Karen Fernandes


G1 (44% ) = TT genotype group = poorer balance
G2 (56%) = TC or CC genotypes = better balance

Balance Test

Need more balance area (Center of Pressure)
for 1-legged stand: 14 vs 10


Sway more if TT VDR

Note: Falls are associated with low Vitamin D blood levels
The VDR (TT) restricts how of it actually gets to the cells

Falls and Fractures category contains the following summary



Vitamin D Receptor category has the following

499 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (18 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (34 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

PDF is available free at Sci-Hub   10.1007/978-3-319-94373-2_44
This study aimed to assess the association between VDR polymorphisms and postural balance in physically independent elderly. 142 elderly persons were enrolled at this case-control study. In order to assess the balance, the individuals performed three 30-s trials of one-legged stance balance test on a BIOMEC400 force-platform (EMG System of Brazil, SP Ltda.), following a standardized protocol (with 30 s of rest between each trial). The main balance parameters used for analysis were: center of pressure area (COP), sway velocity (cm/s) and frequency (s) in both the antero-posterior (A/P) and the medio-lateral (M/L) axes. The VDR TaqI polymorphism analysis was by PCR-RFLP. The case group showed lower values of COP, sway velocity in A/P and M/L axes (p = 0.0007). Similar data were observed regarding frequency in A/P (p = 0.04) and M/L axes (p = 0.03). Therefore, carriers of the “C” allele have a better postural balance when compared to individuals with “T” allele.


1. Fleg, J.L., Morrell, C.H., Bos, A.G., Brant, L.J., Talbot, L.A., Wright, J.G., et al.: Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation 112, 674–682 (2005)
CrossRefGoogle Scholar
2. Corriveau, H., Prince, F., Hebert, R., Raiche, M., Tessier, D., Maheux, P., et al.: Evaluation of postural stability in elderly with diabetic neuropathy. Diab. Care. 23, 1187–1191 (2000)
CrossRefGoogle Scholar
3. Horak, F.B., Shupert, C.L., Mirka, A.: Components of postural dyscontrol in the elderly: a review. Neurobiol. Aging 10, 727–738 (1989)
CrossRefGoogle Scholar
4. Hughes, M.A., Duncan, P.W., Rose, D.K., Chandler, J.M., Studenski, S.A.: The relationship of postural sway to sensorimotor function, functional performance, and disability in the elderly. Arch. Phys. Med. Rehab. 77, 567–572 (1996)
CrossRefGoogle Scholar
5. Stelmach, G.E., Teasdale, N., Di Fabio, R.P., Phillips, J.: Age related decline in postural control mechanisms. Int. J. Aging Hum. Dev. 29, 205–223 (1989)
CrossRefGoogle Scholar
6. Woollacott, M.H., Shumway-Cook, A.: Changes in posture control across the life span—a systems approach. Phys. Ther. 70, 799–807 (1990)
CrossRefGoogle Scholar
7. Ji, G.R., Yao, M., Sun, C.Y., Li, Z.H., Han, Z.: BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis. Bone 47, 681–686 (2010)
CrossRefGoogle Scholar
8. Fang, Y., Rivadeneira, F., van Meurs, J.B., Pols, H.A., Ioannidis, J.P., Uitterlinden, A.G.: Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. Bone 39, 938–945 (2006)
CrossRefGoogle Scholar
9. Aerssens, J., Dequeker, J., Peeters, J., Breemans, S., Broos, P., Boonen, S.: Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporos. Int. 11, 583–591 (2000)
CrossRefGoogle Scholar
10. Alvarez-Hernández, D., Naves, M., Díaz-López, J.B., Gómez, C., Santamaría, I., Cannata-Andía, J.B.: Influence of polymorphisms in VDR and COLIA1 genes on the risk of osteoporotic fractures in aged men. Kidney Int. Suppl. 63, S14–S18 (2003)
CrossRefGoogle Scholar
11. Berg, J.P., Falch, J.A., Haug, E.: Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. Eur. J. Endocrinol. 135, 96–100 (1996)
CrossRefGoogle Scholar
12. Chatzipapas, C., Boikos, S., Drosos, G.I., Kazakos, K., Tripsianis, G., Serbis, A., Stergiopoulos, S., Tilkeridis, C., Verettas, D.A., Stratakis, C.A.: Polymorphisms of the vitamin D receptor gene and stress fractures. Horm. Metab. Res. 41, 635–640 (2009)
CrossRefGoogle Scholar
13. Feskanich, D., Hunter, D.J., Willett, W.C., Hankinson, S.E., Hollis, B.W., Hough, H.L., Kelsey, K.T., Colditz, G.A.: Vitamin D receptor genotype and the risk of bone fractures in women. Epidemiology 9, 535–539 (1998)
CrossRefGoogle Scholar
14. Bischoff-Ferrari, H.A., Dawson-Hughes, B., Staehelin, H.B., et al.: Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339, b3692 (2009)
CrossRefGoogle Scholar
15. Gillespie, L.D., Robertson, M.C., Gillespie, W.J., et al.: Interventions for preventing falls in older people living in the community. Cochrane Database Syst. Rev. 9, CD007146 (2012)
Google Scholar
16. Davidson, B.S., Madigan, M.L., Nussbaum, M.A.: Effects of lumbar extensor fatigue and fatigue rate on postural sway. Eur. J. Appl. Physiol. 93, 183–189 (2004)
CrossRefGoogle Scholar
17. Gribble, P.A., Hertel, J.: Effect of hip and ankle muscle fatigue on unipedal postural control. J. Electromyog. Kinesiol. 14, 641–646 (2004)
CrossRefGoogle Scholar
18. Rizzoli, R., Stevenson, J.C., Bauer, J.M., Van Loon, L.J., Walrand, S., Kanis, J.A., Cooper, C., Brandi, M.L., Diez-Perez, A., Reginster, J.Y.: ESCEO Task Force. The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Maturitas 79, 122–132 (2014)
CrossRefGoogle Scholar
19. Hildebrand, R.A., Miller, B., Warren, A., Hildebrand, D., Smith, B.J.: Compromised vitamin D status negatively affects muscular strength and power of collegiate athletes. Int. J. Sport Nutr. Exerc. Metab. 26, 558–564 (2016)
CrossRefGoogle Scholar
20. Gifondorwa, D.J., Thompson, T.D., Wiley, J., Culver, A.E., Shetler, P.K., Rocha, G.V., Ma, Y.L., Krishnan, V., Bryant, H.U.: Vitamin D and/or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation. Muscle Nerve 54, 1120–1132 (2016)
CrossRefGoogle Scholar
21. Takkouche, B., Montes-Martinez, A., Gill, S.S., Etminan, M.: Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf. 30, 171–184 (2007)
CrossRefGoogle Scholar
22. Holbein, J.M.A., Dermott, M.C.K., Shaw, C., Demchak, J.: Validity of functional stability limits as a measure of balance in adults aged 23–73 years. Ergonomics 50, 631–646 (2007)
CrossRefGoogle Scholar
23. Pollock, A.S., Durward, B.R., Rowe, P.J., Paul, J.P.: What is balance? Clin. Rehabil. 14, 402–406 (2000)
CrossRefGoogle Scholar
24. Nguyen, D.T., Kiel, D.P., Li, W., Galica, A.M., Kang, H.G., Casey, V.A., et al.: Correlations of clinical and laboratory measures of balance in older men and women. Arth. Care Res. 64, 1895–1902 (2012)
CrossRefGoogle Scholar
25. Hurvitz, E.A., Richardson, J.K., Werner, R.A., Ruhl, A.M., Dixon, M.R.: Unipedal stance testing as an indicator of fall risk among older outpatients. Arch. Phys. Med. Rehabil. 81, 587–591 (2000)
CrossRefGoogle Scholar
26. Boersma, D., Demontiero, O., Mohtasham, A.Z., Hassan, S., Suarez, H., Geisinger, D., Suriyaarachchi, P., Sharma, A., Duque, G.: Vitamin D status in relation to postural stability in the elderly. J. Nutr. Health Aging. 16, 270–275 (2012)
CrossRefGoogle Scholar
27. Haetholt, K.A.: Costeffectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study). BMC Geriatri. 11, 48 (2011)
CrossRefGoogle Scholar

Created by admin. Last Modification: Monday July 2, 2018 21:52:05 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
10068 Sway.jpg admin 01 Jul, 2018 18:04 8.92 Kb 760
10067 Center of Pressure.jpg admin 01 Jul, 2018 18:04 10.42 Kb 706
10066 Balance test.jpg admin 01 Jul, 2018 18:04 15.65 Kb 706