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Knee osteoarthritis treated by Vitamin D - many studies


Knee Osteoarthritis 1.7 more likely if low Vitamin D - Jan 2024

Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects
Technol Health Care. 2024 Jan 4. doi: 10.3233/THC-230802 PDF Price: EUR 27.50
Seçkin Özgür Tekeli 1, Özkan Köse 1 2, Dilek Yapar 3, Feyza Yağmur Tekeli 4, Mehmet Melih Asoğlu 1, Emre Mücahit Kartal 1

Background: The extent of the association between vitamin D deficiency and knee osteoarthritis remains inadequately understood.

Objective: This study aimed to elucidate the relationship between vitamin D levels and knee osteoarthritis through a cross-sectional analysis.

Methods: This retrospective study involved an analysis of knee radiographs and serum 25-hydroxyvitamin D3 (25-(OH) vitamin D3) levels in a cohort of 3424 individuals (2901 women and 523 men). Knee osteoarthritis severity was evaluated using the Kellgren-Lawrence radiological scoring system.

Results: Of the participants, 49.2% (n= 1,683) were diagnosed with knee osteoarthritis. Among these patients, the levels of adjusted 25-(OH) vitamin D3 were significantly lower (p< 0.001). Regression analysis revealed a significant association between vitamin D deficiency and knee osteoarthritis, with an adjusted odds ratio (OR) of 1.7 (95% CI: 1.5-2.0; p< 0.001). Notably, a stronger association was observed between vitamin D deficiency and knee osteoarthritis in women under 65 compared to those aged 65 and above.

Conclusions: The findings of this study indicate a higher prevalence of vitamin D deficiency in patients with knee osteoarthritis. Maintaining adequate serum 25-(OH) vitamin D3 levels may prevent knee osteoarthritis, especially in women below 65.


Both Vitamin D and Magnesium appear to be needed if have Knee Osteoarthritis - Oct 2023

__Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis
Magnes Res. 2023 Jun 1;36(2):40-48. doi: 10.1684/mrh.2023.0515 PDF behind paywall
Ebru Yilmaz 1, Sena Ünver 2

The maintenance of various physiological cellular processes requires mineral magnesium (Mg). The purpose of the study was to determine a possible association between Mg level and vitamin D levels, bone mineral density (BMD), chronic diseases, and radiographic stage in individuals with knee osteoarthritis (OA). The study included 98 individuals (62 female and 36 male) who had been diagnosed with at least grade 1 knee OA. Age, sex, smoking, body mass index (BMI), family history of osteoporosis, menopausal status, duration of menopause, the presence of chronic diseases (hypertension, diabetes mellitus, hyperlipidaemia, coronary artery disease, hypothyroidism) and radiological stage of knee OA were gathered from all patients. Also, serum calcium, Mg, alkaline phosphatase, parathyroid hormone (PTH) and 25(OH)-vitamin D levels were recorded. Additionally, dual-energy X-ray absorptiometry (DEXA) was used to measure the BMD of the lumbar vertebrae (L1-L4) and femoral neck as well as anteroposterior radiography of the knee in all patients. T scores ≤-2.5 were accepted as evidence of osteoporosis. The mean age of the study population was 59.15 ± 10.58 years.

The level of Mg significantly correlated with age, smoking, presence of chronic disease, duration of menopause, the level of vitamin D and PTH, and femoral neck T score (p<0.05). This study provides data supporting the relationship between magnesium levels and PTH and vitamin D levels, bone mineral density, and chronic disease. Future research is needed to examine the potential link between knee osteoarthritis and magnesium status.


Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022

The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis
Immunol Res . 2022 Dec 26. doi: 10.1007/s12026-022-09354-0
Ana Divjak 1 2, Ivan Jovanovic 3, Aleksandar Matic 4 5, Aleksandra Tomic Lucic 6 7, Nevena Gajovic 3, Milena Jurisevic 8, Aleksandra Jurisic Skevin 1 2, Mirjana Veselinovic 9 10

This trial aimed to determine the possible therapeutic and immunomodulatory effects of vitamin D3 in patients with knee OA. In this open-label clinical trial, symptoms were assessed over 3 months in patients with primary knee OA receiving oral vitamin D3 4000 IU/day. Clinical response was evaluated at baseline and 3 months using WOMAC subscores and VAS. Serum levels of cytokines IL-1ß, TNF-a, IL-13, IL-17, IL-33, IL-4, and IL-10 were determined by ELISA method. Eighty patients with knee OA were included. All 80 completed the study; the median 25(OH)D3 level was 23.1 ng/ml at baseline and increased by 12.3 ng/ml after treatment. Vitamin D3 after 3 months of supplementation induced a significant reduction in VAS pain and WOMAC subscores. Using OMERACT-OARSI criteria, 86.7% of patients treated with vitamin D3 responded to treatment. At the end of 3 months, systemic values of IL-1ß (p < 0.01), IL-23 (p < 0.01), and IL-33 (p < 0.01) were significantly increased, values of TNF-a (p < 0.01), IL-13 (p < 0.01), and IL-17 (p < 0.01) were significantly decreased, while value of IL-4 was not significantly changed. No adverse events were detected. Treatment with vitamin D is associated with improvement in pain, as well as stiffness and physical function. Vitamin D supplementation increased systemic values of IL-33. Our results indicate that vitamin D3 supplementation may be used as a novel therapeutic in knee OA. Future studies are needed to investigate a potential role of IL-33 in the pathogenesis of knee OA.


Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression - May 2023

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VitaminDWiki - 4 studies in both categories Osteoarthritis and Intervention

This list is automatically updated


VitaminDWiki - Osteoarthritis category contains

58 items total - see also Overview Osteoporosis and vitamin D

Overview Osteoarthritis and Vitamin D
Knee Osteoarthritis treated by Vitamin D - meta-analysis Aug 2023
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020

Click here for 2014 study


VitaminDWiki - Pain - chronic category contains

159 items in category Chronic pain

See also


27+ VitaminDWiki pages with KNEE OSTEOARTHRITIS in title

This list is automatically updated

Items found: 28
Title Modified
Knee osteoarthritis treated by Vitamin D - many studies 13 Dec, 2023
Knee osteoarthritis treated by Vitamin D - many studies 31 Oct, 2023
Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023 21 Aug, 2023
I needed more than Vitamin D to treat my knee osteoarthritis 06 Nov, 2021
Knee osteoarthritis helped by Low Level Laser Therapy 02 Nov, 2020
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 21 Oct, 2020
Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 10 Oct, 2018
Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 10 Jul, 2018
Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 29 Jul, 2017
Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 29 Jul, 2017
Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 29 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 25 Apr, 2017
Knee osteoarthritis strongly associated with low Boron – 2015 24 Mar, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 21 Dec, 2016
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 06 Oct, 2016
Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 06 Oct, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 08 Mar, 2016
Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 03 Oct, 2015
Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT 08 Aug, 2015
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 12 Apr, 2015
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 23 Feb, 2015
Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 07 Oct, 2014
Blacks had lower vitamin D and more quantifiable pain than whites with knee osteoarthritis – Nov 2012 11 May, 2014
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 10 Nov, 2012
Knee Osteoarthritis pain cut in half by eating sesame seed powder for 2 months - Oct 2019 No value for &#039;modification_date_major&#039;

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