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Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017

Vitamin D receptor gene polymorphisms are associated with multiple sclerosis in Mexican adults

Journal of Neuroimmunology, online 3 February 2017
Víctor Hugo Bermúdez-Moralesa, Geny Fierrosa, Roberto Lopez Lopeza, Gaby Martínez-Navaa,
Mario Flores-Aldanab, José Flores-Riverac, Carlos Hernández-Girónd, ,
a National Institute of Public Health, Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos CP 62100, Mexico
b Nutrition and Health Research Center, National Institute of Public Health, Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos CP 62100, Mexico
c Department of Neurology, National Institute of Neurology and Neurosurgery, Avenida Insurgentes Sur 3877, Ciudad de México, D.F. CP 3877, Mexico
d Department of Epidemiology, Population's Health Research Center, National Institute of Public Health, Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos CP 62100, Mexico

VitaminDWiki

The articles in both MS and Genetics are:

The articles in both MS and Vitamin D Receptor are:

Vitamin D Receptor category has the following

267 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 52 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation.
You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

If poor Vitamin D Receptor

Risk
increase
Health Problem
15Chronic Heart Failure
13Sepsis
9.6Chronic Periodontitis
   and smoke
8Juvenile Rheumatoid Arthritis
7.6Crohn's disease
7.5Respiratory Tract Infections
5.8Low back pain in athletes
5 Respiratory Distress in preemies
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer 16.9 X another study
4.1Vitiligo
4Graves Disease
4Polycystic ovary syndrome
3.6 Pneumonia - children
3.3 Pre-term birth
3.1 Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
3Leprosy - another says 28X
2.9Hand, Foot, Mouth Disease
2.8Osteoporosis & COPD
2.7Gastric Cancer
2.6Lupus in children
2.5 Lumbar Disc Degeneration
2.4Lung Cancer
2.3Autism
2.2Juvenile idiopathic arthritis
2.1Adolescent idiopathic scoliosis in Asians
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
2Preeclampsia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.8Sleep Apnea
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.5Obesity
1.4Graves Disease
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Psoriasis in Caucasians
1.3Tuberculosis
?? Rickets - Vitamin D resistant
  • One MS "cure" uses very large doses of Vitamin D
    *If people knew when they have a poor VDR they should be able to just take more Vitamin D to grealy reduce their chance of MS, etc
    *Note: A low-cost VDR test exists - see above


Background
Multiple sclerosis (MS) is the most prevalent autoimmune inflammatory demyelinating disease of the central nervous system (CNS) in young adults. More than 50 genomic regions have been associated with MS susceptibility.

Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms – which interfere with the actions of Vitamin D- could be related to increased risk of MS.

Methods
We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez in Mexico City. Genotyping of VDR gene polymorphisms BsmI (rs1544410) and TaqI (rs731236) was performed using TaqMan SNP Genotyping Assay which consists of a predesigned mix of unlabeled polymerase chain reaction (PCR) primers and the TaqMan minor groove binding group (MGB) probe (FAM dye-labeled).

Results
There was a statistically significant, positive association between MS and the T/T genotype of BsmI polymorphism (OR = 4.15; 95%CI 1.83–9.39), showing also a significant positive trend across genotypes (p < 0.01).
This association was also present evaluating the recessive inheritance model of the polymorphism (OR = 3.91; 95%CI 1.77–8.64). When evaluating the association by alleles, the statistically significant positive association seen by genotypes was confirmed in the T allele carriers, showing an OR of 1.83 (95%CI 1.27–2.65) for MS.

Conclusions
We found a positive association of the genetic VDR polymorphisms TaqI (rs731236) and BsmI (rs1544410), with the risk of MS in a sample of Mexican adults.

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