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4 Cardiovascular diseases are associated with little vitamin D getting to cells – May 2023

Recent Advances in Association Between Vitamin D Levels and Cardiovascular Disorders

Current Hypertension Reports (2023) https://doi.org/10.1007/s11906-023-01246-4
Pahel Agarwal, Yash Agarwal & Maha Hameed

Study sections
Purpose of Review
In this review, we discuss the evidence that vitamin D affects cardiovascular disease through interventional and observational studies and their corresponding association mechanisms. We also highlight the need for further research to definitively conclude clinical recommendations based on preliminary data and determine the extent to which vitamin D levels may impact the incidence and prognosis of major cardiovascular diseases in the future.

Recent Findings
Cardiovascular disease has long been recognized as the leading cause of morbidity and mortality worldwide, with many risk factors implicated in its pathogenesis. Vitamin D is a risk factor that, despite being known to be crucial for its role in maintaining bone health, also has several extra-skeletal effects due to vitamin D receptors in vascular smooth muscle and cardiomyocytes. Recent studies have documented a significant association between higher vitamin D levels and lower risk of each cardiovascular disease entity;

  • 11 studies between serum vitamin D and heart failure,
  • 7 studies between serum vitamin D and hypertension,
  • 8 studies between serum vitamin D and coronary artery disease, and
  • 5 studies between serum vitamin D and atrial fibrillation.

More studies documenting a significant association between increased serum vitamin D and cardiovascular disease are in the context of heart failure compared to hypertension, coronary artery disease, and atrial fibrillation. Conversely, a significant association between increased serum vitamin D and a lower risk of atrial fibrillation is reported in fewer studies compared to the association of vitamin D with other cardiovascular disease entities. Although there is evidence documenting a clear significant association of vitamin D under each category, further research is still needed to definitively conclude the role of vitamin D in cardiovascular disease management.

Conclusion (from PDF)

Being the leading cause of morbidity and mortality, cardiovascular disease risk factors such as vitamin D levels have much potential based on recent evidence through interventional and observational studies. A significant association, along with the mechanism of association between vitamin D and cardiovascular disease entities, including heart failure, hypertension, coronary artery disease, and atrial fibrillation, has been documented in the literature. Although most studies have been reported in the context of vitamin D and heart failure, with literature even detailing the effect of vitamin D on the quality of life of heart failure patients and a predictor for risk of hospitalization, a definitive clinical recommendation has yet to be made. Indeed, a conclusive role of vitamin D in impacting overall cardiovascular disease remains to be established through future research.

 Download the PDF from VitaminDWiki

VutaminDWiki – Hypertension category contains

161 items in the category HYPERTENSION

see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

VitaminDWiki – Cardiovascular category contains

494 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

Cholesterol, Statins

22+ VitaminDWiki pages with AFIB or FIBRILATION in title

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Items found: 23
Title Modified
Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 11 Jul, 2023
Afib in Finland reduced 30% by Vitamin D (3200 IU) – RCT June 2023 09 Jul, 2023
Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis May 2023 27 May, 2023
Atrial Fibrillation - now 1 in 45 in the UK - May 2023 26 May, 2023
Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT April 2022 13 Nov, 2022
Atrial Fibrillation risk reduced by 0.84 in those raising Vitamin D levels above 30 ng – RCT April 2022 04 Apr, 2022
Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018 16 Jan, 2019
Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues 14 Dec, 2018
Osteoporosis treatment with Vitamin D – far healthier and 10X fewer afib events (vs bisphosphonates) – Oct 2018 30 Oct, 2018
Afib increase by 3X for the 1 in 16 people having poor genes (example of health problem) – Aug 2018 14 Oct, 2018
Atrial fibrillation - Vitamin D improved 1 of 4 measures – March 2015 27 Jun, 2018
Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018 27 Jun, 2018
Atrial Fibrillation strongly associated with some vitamin D binding protein – Dec 2017 09 Dec, 2017
Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016 15 Oct, 2017
Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015 10 Dec, 2016
Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016 26 Sep, 2016
Atrial fibrillation and low vitamin D: both types of AF are very low – Jan 2014 01 Nov, 2015
Atrial Fibrillation - remineralize your heart - Aug 2015 25 Oct, 2015
Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015 02 Sep, 2015
Atrial fibrillation reduced with modest vitamin D levels (did not consider Magnesium) – May 2015 05 May, 2015
Higher vitamin D levels associated with health and lower risk of atrial fibrillation – May 2015 02 May, 2015
Active vitamin D decreased atrial fibrillation occurrence by 9X and duration by 77X (rabbits) – March 2014 13 Feb, 2015
Atrial Fibrillation associated with lower levels of vitamin D – July 2012 13 Dec, 2013

VitaminDWiki – Stroke category contains

115 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke

VitaminDWiki - 6 studies in both categories Cardiovascular and Vitamin D Receptor

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Attached files

ID Name Comment Uploaded Size Downloads
19649 ToC CVD.jpg admin 07 Jun, 2023 19:54 75.58 Kb 76
19648 Recent Advances D and CVD_CompressPdf.pdf PDF 2023 admin 07 Jun, 2023 19:53 271.25 Kb 30