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Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020

Clinical Significance of Analysis of Vitamin D Status in Various Diseases

Nutrients 2020, 12(9), 2788; https://doi.org/10.3390/nu12092788
by Magdalena Kowalówka 1OrcID,Anna K. Główka 1OrcID,Marta Karaźniewicz-Łada 2,* and Grzegorz Kosewski 1

  • 1 Department of Bromatology, Poznan University of Medical Sciences, 42 Marcelińska Street, 60-354 Poznań, Poland
  • 2 Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland

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VitaminDWiki suspects about half of the people with Vitamin D deficient diseases
   have enough Vitamin D in their blood, but not in their cells
For many it is more important to increase vitamin D and D getting to cells than to get a Vitamin D test

Genes - some of which can be improved by supplements
CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
Blood Test Misses a lot (VDW 3439)

Cancers might alter CYP24A1 gene

Vitamin D Binding Protein category listing has 140 items and the following introduction

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

  • GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
  • The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
  • The actual D getting to the cells is a function of measured D and all 4 genes
  • There is >2X increase in 8+ health problems if have poor VDBP (GC)
  • It appears that VDBP only blocks oral vitamin D,


Vitamin D Binding Protein has a list of health problems

Increased
Risk
Health Problem
11 XPreeclampsia
6 XFood Allergy
5 XPTSD
4 X, 5XKidney Cancer
4 XPoor Response to Oral Vitamin D
3 XEar infection
2 X MS
2 X Colorectal Cancer
2 XProstate Cancer -in those with dark skins
1.3 XInfertility

Vitamin D Receptor

Additional information on the Genes in VitaminDWiki

Gene# of pages Location
CYP27A1449 (Sept 2019) Liver
CYP2R1 826 (Sept 2019)Liver & Tissue
CYP27B11430   (Sept 2019) Kidney & Tissue
CYP24A1 1360   (Sept 2020) excrete excess


Cofactors (in addition to Vitamin D Receptor supplements)
Vitamin D Cofactors in a nutshell table show the importance of each

Supplement  # of
studies
Increase D
to tissue
Omega-3 329
Many benefits30%?
Magnesium 257
Many need Mg30%
Calcium 191
Reduce
Vitamin K 126
Hard bones,
soft arteries
Iron 53
Vitamin B12 42
Zinc 49
?%
Boron 28
+20%
Iodine 24
Resveratrol 35
>100% if
poor VDR
Curcumin 10
? ?% if
poor VDR

 Download the PDF from VitaminDWiki

Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but also in the immune system, the cardiovascular system and the growth and division of cells. Although numerous studies have reported on the analysis of vitamin D status in various groups of patients, the clinical significance of measurements of vitamin D forms and metabolites remains ambiguous. This article reviews the reports analyzing the status of vitamin D in various chronic states. Particular attention is given to factors affecting measurement of vitamin D forms and metabolites. Relevant papers published during recent years were identified by an extensive PubMed search using appropriate keywords. Measurement of vitamin D status proved to be a useful tool in diagnosis and progression of metabolic syndrome, neurological disorders and cancer. High performance liquid chromatography coupled with tandem mass spectrometry has become the preferred method for analyzing the various forms and metabolites of vitamin D in biological fluids. Factors influencing vitamin D concentration, including socio-demographic and biochemical factors as well as the genetic polymorphism of the vitamin D receptor, along with vitamin D transporters and enzymes participating in vitamin D metabolism should be considered as potential confounders of the interpretation of plasma total 25(OH)D concentrations.


Created by admin. Last Modification: Friday September 11, 2020 22:59:14 GMT-0000 by admin. (Version 14)

Attached files

ID Name Comment Uploaded Size Downloads
14295 Factors for D getting to cells.jpg admin 11 Sep, 2020 18:46 43.29 Kb 65
14294 Vitamin D Status in Various Diseases Sept 11_compressed.pdf PDF 2020 admin 11 Sep, 2020 18:46 476.21 Kb 14
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